2024 NFL Week 6 Odds and Predictions

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It’s hard to believe we’re already heading into Week 6 of the 2024 NFL season. With five weeks behind us, the league has already served up its share of surprises and breakout performances. Week 5 kept the momentum going with some thrilling finishes, but now it’s time to shift our focus to the exciting matchups ahead this week.

Week 6 begins with a Thursday night clash as the San Francisco 49ers hit the road to face their division rivals, the Seattle Seahawks. This NFC West battle could have significant playoff implications down the line. As the weekend unfolds, we’ll also see the Cincinnati Bengals squaring off against the New York Giants in a matchup between a couple of squads looking to find their footing.

With each passing week, the stakes are getting higher, and Week 6 brings a host of opportunities for bettors. Let’s break down the latest NFL odds and offer predictions for each matchup.

2024 NFL Week 6 Schedule

NFL Week 6 Predictions

Let’s take a deeper dive into the odds and make our favorite NFL picks for each game on the Week 6 schedule.

San Francisco 49ers vs. Seattle Seahawks Odds

The San Francisco 49ers head to Seattle to face the Seahawks on Thursday Night Football in what promises to be an electrifying NFC West showdown. Both teams are fresh off of shocking home losses last week. The Niners fell in heartbreaking fashion to the Arizona Cardinals, while the Seahawks were upset by the Giants despite entering the game favored by nearly a touchdown. San Francisco is favored by a field goal on the road in this one.

What’s with the 49ers? The reigning NFC champs are just 2-3 to begin the year. They’re clearly missing all-everything running back Christian McCaffrey, who’ll remain sidelined this week with his Achilles tendinitis. That said, backup Jordan Mason has done an admirable job filling in. The Georgia Tech product has carried the ball 105 times for 536 yards with 3 touchdowns on the year starting in C-Mac’s place.

Protecting the football will be key for Brock Purdy and the offense. Purdy threw a pair of interceptions in Sunday’s loss, while Mason also lost a fumble deep in Arizona territory. Purdy has already thrown for more than 1,300 yards on the young season, but he’s also thrown 4 interceptions. Purdy’s completion percentage of 54.3 percent on Sunday was his worst mark through 5 games on the year.

Seattle’s offense, led by Geno Smith, has shown flashes of brilliance this season, but the offensive line will have its hands full dealing with Nick Bosa and the 49ers’ pass rush. If Seattle wants to stay competitive, Kenneth Walker III will need to establish a ground game early to keep the 49ers’ defense honest.

After exploding for 3 touchdowns in his first game back from an oblique injury in Week 5, Walker was a no-show in Week 6 against New York. He curiously garnered just 5 carries for 19 yards, though he did haul in 7 passes on 8 targets. Walker is averaging 5.5 yards per carry on the year, so the decision to phase him out against the Giants was a curious one, to say the least. The 3rd-year back is going to have to play a much more significant role this week if the Seahawks want to avoid a 3rd straight defeat.

San Francisco 49ers vs. Seattle Seahawks Predictions

Spread: Seahawks +3 (-102)

• The 49ers are favored, but I don’t mind taking the value that comes with betting on the Seahawks to cover or win this game outright as home underdogs. Neither team is coming into this one in particularly impressive form.

Moneyline: 49ers -166 / Seahawks +140

• The 49ers are solid favorites here, and while the Seahawks could keep it close, San Francisco has the edge in almost every department.

Total: 47.5

• With both offenses capable of putting up points, this game could very well hit the over. However, both defenses have shown flashes of brilliance, making this a tricky total to bet.

Betting Trends:

• The 49ers are 5-1 ATS in their last 6 road games.
• The Seahawks are 6-3 ATS in their last 9 games as home underdogs.
• The total has gone over in 4 of the last 5 meetings between these teams.

Prediction: Seahawks +3, Over 47.5
Best Bet: Seahawks +3 (-102)

Jacksonville Jaguars vs. Chicago Bears Odds

The Jacksonville Jaguars will tangle with the Chicago Bears in London for an early morning matchup. The Jaguars have been no stranger to the United Kingdom over the years, and they’ll take on the Bears here following their first win of 2024. Jacksonville is favored by a little less than a field goal in a game with a 44.5 over/under. This game will take place at Tottenham Hotspur Stadium, where the Minnesota Vikings beat the New York Jets last week.

The Jags’ offense has been a work in progress all season long, but they may have found something in backup running back Tank Bigsby. The 2nd-year rusher had the best game of his young career in Sunday’s win over the Indianapolis Colts, rushing the ball 13 times for 101 yards with a couple of touchdowns. Travis Etienne, meanwhile, struggled his way to just 17 yards on 6 carries.

Jacksonville’s early-season struggles have also overshadowed the excellent start of rookie wideout Brian Thomas Jr. Thomas – who was largely overshadowed at LSU last season by Jayden Daniels and Malik Nabers – has already become one of Trevor Lawrence’s favorite weapons. The speedster has caught 22 passes for 397 yards and 3 touchdowns already this season after his first career 100-yard game against the Colts in Week 5.

The Bears also picked up a win in Week 5, and they’ve improved to 3-2 on the season following an inauspicious 0-2 start. While Daniels is still getting most of the attention among 1st-year QBs, the recent exploits of Caleb Williams shouldn’t be overlooked. Williams completed 20 of his 29 attempts for 304 yards with a couple of touchdowns and no interceptions in Chicago’s dominant 36-10 win over the Carolina Panthers. He’s quickly developed a nice rapport with receiver DJ Moore, who led the Bears with 105 yards and scored both of Chicago’s receiving TDs on Sunday.

It’s also been important for the Bears to get their running game on track. After starting the year with 3 dreadful performances, D’Andre Swift has bounced back by rushing for 166 yards and a couple of TDs over the last 2 games.

Jacksonville Jaguars vs. Chicago Bears Predictions

Spread: Jaguars +2.5 (-112)

• The Bears are slight favorites, but I don’t think the Jaguars are as terrible as their 1-4 record indicates. This is a fragile line, so I don’t mind taking the extra value you get by betting on Jacksonville to win or cover.

Moneyline: Jaguars +114 / Bears -135

• With Lawrence heating up, the Jaguars have upset potential here, but the Bears have been more consistent overall.

Total: 44.5

• This total feels spot on, but both teams have the ability to hit the over with their offensive weapons.

Betting Trends:

• The Jaguars are 4-1 ATS in their last 5 games in October.
• The Bears are 6-2 ATS in their last 8 games against teams with losing records.
• The total has gone over in 4 of the Bears’ last 5 games.

Prediction: Jaguars +2.5, Over 44.5
Best Bet: Jaguars ML (+114)

Cleveland Browns vs. Philadelphia Eagles Odds

The Cleveland Browns will take on the Philadelphia Eagles in what could be a one-sided affair. Deshaun Watson has struggled to regain his old form, and Cleveland’s offense remains one of the least productive in the league. Kevin Stefanski has thus far resisted the calls to bench Watson in favor of Jameis Winston, but it’s getting harder and harder to believe the old Watson is still in there somewhere. At this point, the Browns’ expensive quarterback looks like a complete lost cause.

Watson was as atrocious as ever in Cleveland’s disheartening 34-13 loss to the Washington Commanders in Week 5. The former Houston Texan has completed just over 60 percent of his throws for just 852 yards and 5 touchdowns to 3 interceptions on the year. The Browns’ struggling offensive line hasn’t done Watson any favors, but he has shown no signs of coming around. Watson hasn’t even cracked 200 passing yards in a game this season.

The Browns also aren’t getting any help from a non-existent run game. While the impending return of Nick Chubb could boost their fortunes, the combination of Jerome Ford and D’Onta Foreman hasn’t gotten anything going. Cleveland is just 1-4 on the year, and I doubt they’re going to turn things around until they finally sit Watson on the bench.

The Eagles aren’t doing much better, of course. Philadelphia is off to a 2-2 start after a 33-16 shellacking at the hands of the Tampa Bay Buccaneers back in Week 4. Philly’s Week 5 bye was well-timed, however, as star receivers A.J. Brown and DeVonta Smith are both expected to return from injuries against Cleveland. Brown has been dealing with a hamstring injury, while Smith was recovering from a concussion.

I’m skeptical of the Eagles as Super Bowl contenders with Nick Sirianni patrolling the sidelines, but they should be able to take care of business in this one against a downtrodden and spiritless Browns side. The issue is I don’t love Philadelphia enough to fully trust them to cover this sizable 9-point spread.

Cleveland Browns vs. Philadelphia Eagles Predictions

Spread: Browns +9 (-110)

• I get why the Eagles are such heavy favorites, but 9 points is a huge spread for an NFL game. The Browns suck, but do they suck this much? I think the Browns can at least cover, even if an outright win is a stretch.

Moneyline: Browns +350 / Eagles -455

• Philadelphia is the heavy favorite, and for good reason. The Browns’ offense simply can’t keep up.

Total: 43

• The under is tempting here, with Cleveland’s offense struggling and Philadelphia’s defense locking down opponents.

Betting Trends:

• The Browns are 1-4 ATS in their last 5 games as road underdogs.
• The Eagles are 5-0 ATS in their last 5 home games.
• The total has gone under in 5 of the last 6 meetings between these teams.

Prediction: Browns +9, Under 43
Best Bet: Under 43 (-110)

Washington Commanders vs. Baltimore Ravens Odds

The red-hot Washington Commanders visit their local rivals, the Baltimore Ravens, in what should be one of the most fun matchups of Week 6. Washington is off to a shocking 4-1 start, while Baltimore improved to 3-2 with a dramatic overtime win in Cincinnati last week. Few around the league had this game circled on their schedules before the season began, but this now looks like a terrific game to watch.

Jayden Daniels isn’t just the frontrunner to win NFL Offensive Rookie of the Year. Frankly, he’s in the MVP discussion. The former Heisman Trophy winner didn’t put up monster numbers on Sunday against Cleveland, but he was able to methodically lead the offense to a stress-free 34-13 victory. Daniels completed a season-low 56 percent of his passes for 238 yards with a touchdown while adding 82 rushing yards.

While Daniels has justifiably gotten most of the attention, let’s not ignore how dominant Washington has been in the run game this season. They have Daniels to thank for that in part, but the Commanders have also gotten incredible production out of their running backs. Brian Robinson Jr. added 2 more touchdowns to his ledger on Sunday, while Austin Ekeler and Jeremy McNichols combined for 111 rushing yards on just 13 carries. While the Ravens are still the NFL’s most dominant rushing team, Washington ranks 2nd in the league with 892 rushing yards and 1st in rushing touchdowns (13) as a team.

Daniels is likely the closest approximation we have to Lamar Jackson in the NFL these days. While Daniels is coming for the throne, Jackson is still the king until further notice. The 2-time NFL MVP threw for a season-high 348 yards and 4 touchdowns in Baltimore’s come-from-behind 41-38 win in Cincinnati on Sunday. Lamar has also topped 360 rushing yards with a pair of rushing TDs on the year, while Derrick Henry has proven to be the perfect complement since forming over from the Tennessee Titans this offseason.

After a sluggish start, Henry has turned on the jets over the past 3 games. Over those 3 games – all Ravens wins – Henry has carried the ball 64 times for 442 yards with 6 total touchdowns. Henry leads all NFL rushers with 572 yards and 7 total TDs on the season.

Washington Commanders vs. Baltimore Ravens Predictions

Spread: Commanders +6.5 (-112)

• I’m a bit surprised to see the Ravens favored by nearly a touchdown given how dominant the Commanders’ offense has been this season. I like Washington to cover.

Moneyline: Commanders +235 / Ravens -290

• Baltimore is a solid pick, but Washington’s long-shot moneyline odds could tempt some bettors.

Total: 52.5

• Both teams have the offensive firepower to hit the over. This could be a track meet.

Betting Trends:

• The Commanders are 4-1 ATS in their last 5 road games.
• The Ravens are 6-2 ATS in their last 8 games against NFC teams.
• The total has gone over in 4 of the last 5 meetings between these teams.

Prediction: Commanders +6.5, Over 52.5
Best Bet: Commanders +6.5 (-112)

Houston Texans vs. New England Patriots Odds

The New England Patriots will host the Houston Texans looking to get their season back on track after a disappointing start. New England recorded a shocking Week 1 upset of the Cincinnati Bengals, but it’s been all downhill for Jerod Mayo’s squad ever since. They’re listed as 7-point underdogs here against the 4-1 Texans.

The Patriots mustered all of 10 points in a 15-10 loss to the Miami Dolphins in Week 5. New England’s offense wasn’t expected to be very productive this season, but it sounds like Mayo is already considering a change at quarterback. Jacoby Brissett has completed just 58.5 percent of his passes while averaging a paltry 139 passing yards per game through 5 weeks. We know former No. 3 overall pick Drake Maye is going to get the job at some point this season, and it sounds like that could happen this week in Houston.

While Maye is a promising prospect, throwing him into the fire against a stout Houston defense would be downright cruel. Regardless, we can expect the Patriots to lean heavily on the run game. After he was benched to start Week 5 due to fumbling issues, Rhamondre Stevenson impressed by totaling 89 yards on just 12 carries with a touchdown against Miami. Giving Stevenson the ball and trying to control the tempo of the game is likely the best course of action if the Pats want to have a chance at pulling the upset in this one.

Things haven’t necessarily gone according to plan for the Texans this season, yet they’re still 4-1 following a 23-20 win at home over the Buffalo Bills on Sunday. Houston’s 4 wins have come by a combined 15 points, but wins all count the same in the NFL. The Texans jumped out to a 20-3 lead on Sunday before ultimately staving off Buffalo’s comeback thanks to a last-second, game-winning 59-yard field goal by Ka’imi Fairbairn.

Houston has injury issues on offense, however. Joe Mixon appears likely to miss a 4th straight game after suffering a sprained ankle in the Week 2 win over Chicago. The Texans have struggled to generate much of a ground game since Mixon went down. Leading receiver Nico Collins is also looking doubtful after sustaining a hamstring injury on Sunday. Collins leads all pass-catchers with 567 receiving yards on the year. If he’s out, C.J. Stroud is going to have to rely more heavily on Stefon Diggs and Tank Dell in the pass game.

Houston Texans vs. New England Patriots Predictions

Spread: Texans -7 (-105)

• The Texans should be able to cover the touchdown spread against a struggling Patriots team. Houston’s offense hasn’t been great, but I still don’t think New England can keep up.

Moneyline: Texans -298 / Patriots +240

• Houston is the clear favorite, with their defense and Stroud’s playmaking leading the way.

Total: 37.5

• This total is low for a reason—expect a grind-it-out game with a lot of defense, making the under the safer bet.

Betting Trends:

• The Patriots are 2-5 ATS in their last 7 games as home underdogs.
• The Texans are 5-2 ATS in their last 7 road games.
• The total has gone under in 5 of the last 6 meetings between these teams.

Prediction: Texans -7, Under 37.5
Best Bet: Texans -7 (-105)

Arizona Cardinals vs. Green Bay Packers Odds

The Arizona Cardinals visit the Green Bay Packers at Lambeau Field after both teams picked up wins on the west coast in Week 5. The Cardinals pulled a shocking upset of the 49ers in Santa Clara, while the Packers disposed of the injury-riddled Rams in Los Angeles. These are a couple of high-octane offenses, which explains why this game has one of the higher totals (49.5) of the weekend.

The Packers raised some eyebrows when they headed Jordan Love a lucrative new contract this offseason, but the former Utah State Aggie has played well in 3 starts on the year. Love’s completion percentage (56.1) could stand to improve, but he’s thrown for 873 yards and 8 touchdowns in just 3 games. He’s also thrown more interceptions (5) than he’d like, but this again looks like it’ll be one of the league’s most lethal passing attacks.

Green Bay has also gotten strong production from running back Josh Jacobs. The former NFL rushing champ is averaging 4.5 yards per carry in his first season with the team, while he scored his first TD as a Packer on Sunday in LA.

Despite some turnover issues, the Packers are still tied for the league lead with a plus-7 turnover differential. That’s because the defense has already registered a league-best 14 takeaways, highlighted by a whopping 9 interceptions. Amazingly, veteran safety Xavier McKinney has intercepted a pass in each of the season’s first 5 games.

The Cardinals have been wildly inconsistent to begin the year. They’re 2-3 overall, yet their 2 wins on the year came against their NFC West rivals, the 49ers and Rams. Arizona’s 24-23 win over San Francisco on Sunday was one of the biggest upsets we’ve seen early in the year, and the defense forcing the Niners into 3 turnovers may have been the difference.

The Cardinals are still looking to get their aerial attack into gear. Kyler Murray is off to a decent start overall, but rookie receiver Marvin Harrison Jr. has been very boom-or-bust. Outside of his 130-yard, 2-touchdown effort in the Cardinals’ blowout win over Los Angeles in Week 2, the No. 4 pick in April’s draft has a total of just 149 yards and 2 touchdowns over the other 4 games combined. He reeled in just 2 of his 7 targets for 36 yards against the 49ers.

Arizona Cardinals vs. Green Bay Packers Predictions

Spread: Packers -5.5 (-108)

• The Packers should cover at home, given their high-flying offense and Arizona’s defensive woes.

Moneyline: Cardinals +195 / Packers -238

• Green Bay is the heavy favorite, and they should be able to handle business against an inferior Arizona squad.

Total: 49.5

• Both teams have the potential to put points on the board in bunches, making the over a tempting option.

Betting Trends:

• The Cardinals are 2-6 ATS in their last 8 road games.
• The Packers are 7-3 ATS in their last 10 games as home favorites.
• The total has gone over in 5 of Green Bay’s last 6 games.

Prediction: Packers -5.5, Over 49.5
Best Bet: Packers -5.5 (-108)

Indianapolis Colts vs. Tennessee Titans Odds

The Tennessee Titans and Indianapolis Colts face off in what could be a tightly contested AFC South matchup. The Titans are just 1-3 and coming off of a Week 5 bye, though they did pick up a 31-12 win over the hapless Miami Dolphins in their last game. The Colts staged a furious comeback in Jacksonville last week, only to wind up losing, 37-34, on a game-winning field goal from the Jaguars’ Cam Little. Indy fell to 2-3 with the setback.

Injuries have played an unfortunate role for the Colts so far. Leading rusher Jonathan Taylor missed the Jacksonville game with a sprained ankle, and it’s looking unlikely he’ll be ready to return to the field this week. The Colts’ QB1 – Anthony Richardson – also sat out last week’s game with an oblique injury. While veteran Joe Flacco has played better than Richardson when given the chance, head coach Shane Steichen reiterated on Monday that Richardson will be the starter when he’s healthy enough to return.

It sounds as though that may well happen this week with the Titans in town. Richardson’s rushing potential gives this offense a unique wrinkle, but the passing game remains a work in progress. Richardson has completed just over 50 percent of his pass attempts this season with 3 touchdowns to 6 interceptions. If Taylor sits and Indy again struggles to get the ground game going, points could be difficult to come by here against an underrated Tennessee defense.

The Titans have a questionable young starting QB of their own in Will Levis, who went down with a shoulder injury in the Miami game. Head coach Brian Callahan said Levis will be his starter when healthy and that Mason Rudolph will remain the backup despite performing decently after Levis’ injury in Week 4. The former Kentucky standout has also thrown 6 interceptions on the year, though his 68 percent completion percentage is significantly higher than that of Richardson.

Tennessee is another team that may have to lean on the ground game. Tony Pollard and Tyjae Spears combined for 127 yards and a couple of touchdowns against the Dolphins a couple of weeks ago.

Indianapolis Colts vs. Tennessee Titans Predictions

Spread: Titans +1 (-112)

• This game is essentially a pick’em, but I like the Titans on the road given Richardson’s inconsistency.

Moneyline: Colts -112 / Titans +112

• This is a close matchup, but I’ll take the plus-money value we’re getting with Tennessee on the road.

Total: 43

• Both teams have strong running games, but the over could hit if the QBs manage to make enough plays through the air.

Betting Trends:

• The Titans are 6-2 ATS in their last 8 division games.
• The Colts are 4-1 ATS in their last 5 home games.
• The total has gone under in 4 of the last 5 meetings between these teams.

Prediction: Titans +1, Over 43
Best Bet: Titans ML (+112)

Tampa Bay Buccaneers vs. New Orleans Saints Odds

The Tampa Bay Buccaneers will take a trip to the Big Easy for a key NFC South matchup against the New Orleans Saints. Tampa Bay has been playing well behind the solid play of Baker Mayfield and a resurgent offense. Mike Evans and Chris Godwin continue to be a threat in the passing game, while Rachaad White and Bucky Irving have done enough on the ground to keep defenses honest.

Tampa Bay enters the game at 3-2 on the year after a thrilling overtime loss to the Atlanta Falcons in Week 5. Neither team could do any wrong offensively, though the defenses were another story. The Bucs allowed Kirk Cousins to throw for over 500 yards, so slowing the Saints’ passing attack will likely been a point of focus for Tampa Bay’s coaches at practice all week.

The Saints fell to 2-3 with their loss in Kansas City on Monday night. New Orleans has now dropped 3 straight games following their 2-0 start in which they topped 40 points in both contests. They’ve mustered just 49 points in the last 3 games combined, so it’s looking fairly likely that their blistering offensive start was a flash in the pan.

We’ll see if the Saints are serious about their reported pursuit of Pro Bowl wideout Davante Adams. Reuniting Adams with Derek Carr would bring some legitimacy to a passing attack that has been inconsistent to begin the year. Carr has struggled to get on the same page with former first-rounder Chris Olave, though Rashid Shaheed has been an unexpected bright spot.

The Saints could also stand to get Alvin Kamara back on track. Since totaling 290 yards from scrimmage with 5 touchdowns in Weeks 1 and 2 combined, Kamara has been held to 312 total yards and 1 score in the last 3 games.

Tampa Bay Buccaneers vs. New Orleans Saints Predictions

Spread: Buccaneers +2 (-112)

• Once again, I think the underdog in this game is going undervalued. By the end of the season, I expect the Bucs to be atop the NFC South.

Moneyline: Buccaneers +105 / Saints -125

• New Orleans has the more reliable defense, but the Bucs should put points on the board in the dome here.

Total: 45.5

• Both offenses have the potential to put up points, but the under could hit if the defenses hold strong.

Betting Trends:

• The Buccaneers are 5-2 ATS in their last 7 games as road underdogs.
• The Saints are 4-1 ATS in their last 5 home games.
• The total has gone under in 4 of the last 5 meetings between these teams.

Prediction: Buccaneers +2, Over 45.5
Best Bet: Buccaneers ML (+105)

Los Angeles Chargers vs. Denver Broncos Odds

The Denver Broncos are off to a 3-2 start, which is quite impressive when you consider how little they’ve gotten out of their offense to this point. Denver has rattled off 3 straight wins after beginning the year 0-2, and they’ll put that win streak on the line when they welcome the Los Angeles Chargers to the Mile High City on Sunday afternoon.

Points have been hard to come by for Denver this season, but that wasn’t the case on Sunday against the Las Vegas Raiders. Bo Nix threw for 206 yards with a couple of touchdowns as the Broncos rolled their AFC West rivals, 34-18. Javonte Williams amassed over 100 yards from scrimmage, while the Broncos’ defense picked off Gardner Minshew and Aidan O’Connell 3 times. Patrick Surtain II – who inked a new contract extension last month – had 2 of the interceptions and returned one of them 100 yards for a touchdown.

The Chargers, meanwhile, are 2-2 coming off of a bye in Week 5. LA won their first 2 games of the year, but they’re coming off of consecutive losses to the Pittsburgh Steelers and Kansas City Chiefs. As is the case with Denver, scoring has been an issue for Los Angeles in the early going. The Bolts mustered just 10 points in each of their 2 defeats, which isn’t a huge surprise given the lack of playmakers at Justin Herbert’s disposal.

Herbert was dealing with an ankle injury prior to the bye, but the off week came at a good time. This was always going to be a run-first offense with Jim Harbaugh running the show, and we’ve seen exactly that. LA has run the ball on 53 percent of their offensive snaps so far this season. The Commanders (53.5 percent) are the only team running more frequently. Unfortunately, the Chargers’ average of 4.4 yards per carry ranks just 15th in the NFL, so that style isn’t necessarily paying dividends thus far.

This has all the makings of a low-scoring slugfest. Both defenses have played well to begin the year, and I don’t see much reason to expect a shootout.

Los Angeles Chargers vs. Denver Broncos Predictions

Spread: Broncos +3 (-110)

• I’m not sure the Chargers are good enough to be favored by a field goal on the road, even against what has been a largely punchless Broncos offense.

Moneyline: Chargers -162 / Broncos +136

• You’re getting pretty good bang for your buck if you take a flier on the Broncos at +136 at home to win the game outright.

Total: 36

• Both offenses have underwhelmed at times this season, so the under seems like a solid play here.

Betting Trends:

• The Broncos are 2-6 ATS in their last 8 road games.
• The Chargers are 4-1 ATS in their last 5 games as home favorites.
• The total has gone under in 6 of the last 7 meetings between these teams.

Prediction: Broncos +3, Under 36
Best Bet: Under 36 (-112)

Pittsburgh Steelers vs. Las Vegas Raiders Odds

The struggling Las Vegas Raiders will try to bounce back after a disheartening blowout loss in Denver on Sunday. First-year head coach Antonio Pierce has some issues to sort through, however. While it looks like star wide receiver Davante Adams will never play another snap for the Raiders, Pierce also has to figure out what to do with his quarterback and running back situations. Gardner Minshew has been woefully ineffective thus far, and he was benched in favor of Aidan O’Connell in the second half of Sunday’s loss.

Las Vegas’ team QB rating of 83.2 so far ranks among the worst in the NFL. O’Connell hardly lit the world on fire after taking over for Jimmy Garoppolo last season, but Minshew clearly isn’t the answer. However, O’Connell wasn’t much better after coming on in relief last week, as he completed just 10 of his 20 throws for 94 yards with an interception. This offense is going to struggle to make big plays without Adams in there to provide some stability.

Pierce said before last week’s game that Alexander Mattison has earned some extra playing time at the expense of Zamir White, and that was before White went down with a groin injury in last Thursday’s practice. Mattison was dreadful in a starting role against Denver, rushing 15 times for just 38 yards. Ameer Abdullah – a journeyman scatback – was much more effective, with 42 yards on 5 carries with a touchdown.

The Pittsburgh Steelers are fresh off of a heartbreaking last-second loss at home to the Dallas Cowboys on Sunday night. The poor weather was clearly a factor in that one, as both offenses struggled to find any footing. While Justin Fields has played well overall this season, he only completed about 55 percent of his passes for 131 yards against Dallas. Russell Wilson is waiting in the wings, and I wouldn’t be surprised if Russ ultimately gets a chance to take some snaps if Fields struggles at any point in the future.

The Steelers are one of the teams that has been linked to Adams, and we’ll see if a trade comes to fruition after Pittsburgh wound up missing out on a preseason deal for Brandon Aiyuk. Pittsburgh has been a very run-happy team to this point, but they don’t have much to show for it. Najee Harris is contributing a career-worse 3.3 yards per carry, and he’s yet to find the end zone through 5 games.

Pittsburgh Steelers vs. Las Vegas Raiders Predictions

Spread: Steelers -3 (-110)

• Pittsburgh’s defense should be able to keep Las Vegas in check, making the Steelers a good bet to cover the spread.

Moneyline: Steelers -162 / Raiders +136

• I don’t see much reason to have faith in the Raiders’ offense, especially without Adams. This should be another low-scoring game, which fits exactly what the Steelers want to do.

Total: 36.5

• Given the offensive struggles of both teams, the under looks like the best bet in this game.

Betting Trends:

• The Raiders are 3-5 ATS in their last 8 games as home underdogs.
• The Steelers are 6-2 ATS in their last 8 games as road favorites.
• The total has gone under in 5 of the last 6 games between these teams.

Prediction: Steelers -3, Under 36.5
Best Bet: Steelers -3 (-110)

Detroit Lions vs. Dallas Cowboys Odds

Fresh off of a bye week, the Detroit Lions head to Arlington for a key NFC showdown with the Dallas Cowboys. Dallas won their second consecutive game with a thrilling comeback win over the Steelers in Pittsburgh on Sunday night, and they’re back up to 3-2 following a couple of dispiriting losses to begin the campaign.

Detroit looks like a legitimate Super Bowl threat out of the NFC once again, and you can easily argue they should be the favorites at this point. The Lions picked up a 42-29 win over the Seattle Seahawks back in Week 4 to improve to 3-1. Their only loss to this point was a hard-fought 20-16 setback to the Bucs back in Week 2.

Jared Goff completed all 18 of his passes against Seattle, while the Lions’ running game is still among the league’s best. Opposing defenses haven’t yet solved how to deal with the David Montgomery/Jahmyr Gibbs 2-headed monster out of the backfield. Detroit’s backs have combined to score 8 touchdowns already this season. Gibbs is averaging north of 5 yards per carry, while both players have been reliable safety valves out of the backfield.

The Cowboys haven’t had an easy path to their 3-2 start, but wins are wins in this league. Dak Prescott has had trouble getting onto the same page as CeeDee Lamb, for whatever reason, but some of the other team’s pass-catchers have stepped up. With Brandin Cooks sidelined by a knee injury, Jalen Tolbert went out and racked up a career-high 7 catches for 87 yards with the game-winning score in Pittsburgh on Sunday night.

After beginning the year with Ezekiel Elliott as the starting running back, Dallas seems to have found the solution to their lackluster rushing attack. Rico Dowdle carried the ball 20 times for 87 yards in an impressive effort on Sunday, and this looks like his backfield to lose at this point.

Detroit Lions vs. Dallas Cowboys Predictions

Spread: Lions -3.5 (-105)

• The Lions have been the more consistent team and should be able to cover the 3.5-point spread on the road.

Moneyline: Lions -175 / Cowboys +145

• Detroit is the safer moneyline pick with their more balanced offense and stronger recent form.

Total: 52.5

• This game has shootout potential, making the over an attractive option.

Betting Trends:

• The Lions are 6-2 ATS in their last 8 road games.
• The Cowboys are 3-7 ATS in their last 10 games as home underdogs.
• The total has gone over in 5 of the last 7 games between these teams.

Prediction: Lions -3.5, Over 52.5
Best Bet: Lions -3.5 (-105)

Atlanta Falcons vs. Carolina Panthers Odds

The Atlanta Falcons take on the division rival Carolina Panthers in a game where Atlanta is heavily favored. Atlanta picked up a thrilling OT win over the Bucs last Thursday night, while the Panthers have dropped back-to-back games after Andy Dalton finally got them into the win column back in Week 3.

Kirk Cousins got off to a slow start as he continued to recover from last year’s Achilles injury, but he played a whale of a game against Tampa Bay. The veteran threw for an NFL season-high 509 yards with 4 touchdowns against Tampa Bay, including a game-winning 45-yard strike to Kha’Darel Hodge in overtime. Drake London and Darnell Mooney both topped 100 yards receiving and found the end zone, while Kyle Pitts (7 catches, 88 yards) was finally involved.

While the passing game looks dynamic, the Falcons would like to see more out of Bijan Robinson and the rushing attack. Robinson did average north of 5 yards per carry against the Bucs, but he only finished with 12 attempts and caught 3 passes out of the backfield. Atlanta has been getting backup Tyler Allgeier some work on occasion, but Robinson has still yet to top 20 carries in a game this season.

Carolina has faced challenges all season, and the goodwill Andy Dalton built back in Week 3 may already be wearing thin. The Panthers are just 1-4 after a 36-10 drubbing in Chicago last week, though the offense is still quite a bit more dynamic than it was with Bryce Young running the show.

One bright spot for Carolina has been the play of Chuba Hubbard. The former Oklahoma State star is averaging a healthy 5.8 yards per carry this season, which puts him among the league leaders. Hubbard has at least 97 yards rushing with a touchdown in each of the last 3 games. Still, it’ll be difficult for the undermanned Panthers offense to keep up with a full-strength version of the Falcons in this one.

Atlanta Falcons vs. Carolina Panthers Predictions

Spread: Falcons -6 (-112)

• The Falcons’ improved offense and solid defense make them likely to cover the spread.

Moneyline: Falcons -270 / Panthers +220

• Atlanta is the safer moneyline pick, with their defense set to dominate a weak Panthers offense.

Total: 47.5

• With Carolina’s offensive struggles, the under feels like the better bet.

Betting Trends:

• The Falcons are 4-1 ATS in their last 5 road games.
• The Panthers are 1-6 ATS in their last 7 games as underdogs.
• The total has gone under in 4 of the last 5 meetings between these teams.

Prediction: Falcons -6, Under 47.5
Best Bet: Falcons -6 (-112)

Cincinnati Bengals vs. New York Giants Odds

Fresh off of a devastating loss to the Ravens, the Cincinnati Bengals head to New Jersey for a Sunday night matchup with the New York Giants. Cincinnati has been inconsistent this season, but Joe Burrow has the talent around him to light up any defense. Cincinnati’s offense was firing on all cylinders against Baltimore, but it wasn’t enough in the end.

Burrow had one of the best games of his NFL career on Sunday, throwing for 392 yards with 5 touchdowns and 1 interception. For the season, the former Heisman Trophy winner has nearly 1,400 yards passing with 12 touchdowns, and that’s with Ja’Marr Chase and Tee Higgins both having dealt with early-season injuries.

The Bengals boast one of the most devastating passing attacks in football, but they’re running the risk of getting too one-dimensional. The best offenses in the league have better balance, and we’ll see if Chase Brown and Zack Moss can give them more on the ground moving forward. Cincy was held to just 71 rushing yards on 23 carries as a team by Baltimore, good for a paltry 3.1 yards per carry.

The Giants, meanwhile, picked up an impressive win on Sunday afternoon in Seattle. Despite entering the game as 6.5-point underdogs, Daniel Jones and co. managed to come away with a 29-20 triumph. What makes the win even more impressive is that they did it without Malik Nabers, who sat out with a concussion. Nabers is expected to be ready to roll on Sunday night, which will give New York’s offense a vertical element it lacked in Week 5.

The G-Men were also without leading rusher Devin Singletary against the Seahawks, but rookie Tyrone Tracy Jr. stepped in and delivered a terrific effort. Tracy carried the ball 18 times for 129 yards, which is an average of more than 7 yards per rush. Even if Singletary is healthy enough to return against the Bengals, don’t be surprised if the Giants keep Tracy involved in the rotation.

The Giants will need to rely on their run game to keep Burrow off the field.

Cincinnati Bengals vs. New York Giants Predictions

Spread: Bengals -3.5 (-110)

• Cincinnati’s firepower could be too much for the Giants, but New York has been far better than expected this season. Plus, the Giants are at home.

Moneyline: Bengals -185 / Giants +154

• The Bengals are the better overall team, but their lack of form is concerning. I think the Giants are a decent value to pull the upset.

Total: 49

• With Burrow leading the way and the Giants’ defense struggling, the over is the more appealing bet.

Betting Trends:

• The Bengals are 7-2 ATS in their last 9 games as road favorites.
• The Giants are 2-5 ATS in their last 7 home games.
• The total has gone over in 5 of the last 6 games between these teams.

Prediction: Giants +3.5, Over 49
Best Bet: Giants ML (+154)

Buffalo Bills vs. New York Jets Odds

The Buffalo Bills got off to a 3-0 start, but they’re now 3-2 as they wrap up Week 6 with a Monday night showdown against their AFC East rivals, the New York Jets. The Jets are 2-3 after a loss in London to Minnesota on Sunday that ultimately cost head coach Robert Saleh his job. The Jets fired Saleh on Tuesday, and defensive coordinator Jeff Ulbrich will take over in an interim capacity on Monday night.

We’ll see if the decision to fire Saleh will have any impact on whether New York can get its offense into gear. Aaron Rodgers uncharacteristically threw 3 interceptions on Sunday against the Vikings, while Breece Hall once again struggled to generate much of anything on the ground. After averaging nearly 5 yards per carry through his first 2 years in the league, Hall is contributing just 3 yards per rush so far in 2024. His 65 totes for 197 yards on the season leaves an awful lot to be desired.

The Bills looked like the most impressive team in football through Week 3, but they’ve since dropped back-to-back games to fellow AFC contenders in the Ravens and Texans. Josh Allen is still among the early-season MVP favorites, but Sunday’s performance won’t help his case. He completed a woeful 9 of his 30 throws for just 131 yards, though he did manage to avoid throwing an interception for the 5th straight game.

Buffalo was without leading receiver Khalil Shakir in that game, and he was sorely missed. Keon Coleman paced all Buffalo receivers with just 49 yards, while nobody caught more than 2 passes. Shakir is day-to-day with an ankle injury, and the Bills are optimistic about his chances to return to the field on Monday night.

Buffalo Bills vs. New York Jets Predictions

Spread: Bills -2.5 (-112)

• Buffalo’s offense should be able to overcome the Jets’ defense, giving the Bills the edge to cover the spread.

Moneyline: Bills -142 / Jets +120

• The Bills are the better team overall, and while the Jets have been competitive, Buffalo should win outright.

Total: 41

• This game could be more of a defensive battle, making the under a solid play.

Betting Trends:

• The Bills are 5-2 ATS in their last 7 road games.
• The Jets are 6-3 ATS in their last 9 games as home underdogs.
• The total has gone under in 4 of the last 5 meetings between these teams.

Prediction: Bills -2.5, Under 41
Best Bet: Bills -2.5 (-112)

NFL Week 6 Best Bets

After looking over the entire week, the following wagers are our NFL Week 5 best bets:

• Jacksonville Jaguars moneyline (+114)
• New York Giants moneyline (+154)
• Cleveland Browns +9 (-110)

Betting on these 3 individually offers little payout, but you can parlay them for a bigger payday. Putting $100 down on these 3 wagers will pay out $937.71 if it hits! You can place individual wagers on these NFL best bets or you can combine them for a potential NFL Week 6 parlay.