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Week 12 of the 2024-25 NFL season features six teams on a Bye, along with seven divisional matchups. Of these divisional contests, the two that stand out the most are the Tennessee Titans vs. Houston Texans and the Pittsburgh Steelers vs. Cleveland Browns on Thursday Night Football.
In addition to those games, there’s plenty of drama expected throughout the rest of the week’s action. In fact, the final game of Week 12 pits brother vs. brother when John Harbaugh leads the Baltimore Ravens into Southern California to compete against Jim Harbaugh and the Los Angeles Chargers on Monday Night Football.
Two highly anticipated NFC battles will also highlight the weekend as the San Francisco 49ers head to Lambeau Field to face the Green Bay Packers and the Los Angeles Rams host the Philadelphia Eagles on Sunday Night Football.
The following six teams will have a Week 12 Bye: Atlanta Falcons, Buffalo Bills, Cincinnati Bengals, New Orleans Saints, New York Jets, and Jacksonville Jaguars.
With that in mind, the full slate of NFL Week 12 Odds is not available as of yet. This means that there’s still plenty of time to examine our NFL betting analysis for information and predictions on players, all 32 NFL teams, Divisions, Conferences, and the 2025 Super Bowl.
NFL Week 12 Odds
NFL Week 12 odds are not available as of yet. Check back as we get closer to the start of November and the NFL odds for this week become available.
NFL Week 12 Schedule
| Date | Time (ET) | Road Team | Home Team |
|---|---|---|---|
| Thursday, Nov. 21 | 8:15 PM | Pittsburgh Steelers | Cleveland Browns |
| Sunday, Nov. 24 | 1PM | Minnesota Vikings | Chicago Bears |
| Sunday, Nov. 24 | 1PM | Detroit Lions | Indianapolis Colts |
| Sunday, Nov. 24 | 1PM | New England Patriots | Miami Dolphins |
| Sunday, Nov. 24 | 1PM | Tampa Bay Buccaneers | New York Giants |
| Sunday, Nov. 24 | 1PM | Dallas Cowboys | Washington Commanders |
| Sunday, Nov. 24 | 1PM | Kansas City Chiefs | Carolina Panthers |
| Sunday, Nov. 24 | 1PM | Tennessee Titans | Houston Texans |
| Sunday, Nov. 24 | 4:05 PM | Denver Broncos | Las Vegas Raiders |
| Sunday, Nov. 24 | 4:25 PM | San Francisco 49ers | Green Bay Packers |
| Sunday, Nov. 24 | 4:25 PM | Arizona Cardinals | Seattle Seahawks |
| Sunday, Nov. 24 | 8:20 PM | Philadelphia Eagles | Los Angeles Rams |
| Monday, Nov. 25 | 8:15 PM | Baltimore Ravens | Los Angeles Chargers |
Key NFL Week 12 Games
With Week 12 of the NFL season featuring most of the NFL teams, there are a few key Week 12 games that stand out from the rest:
Pittsburgh Steelers vs. Cleveland Browns
This is the first of two annual games between these AFC North teams. Weirdly, the schedule makers decided to have the Pittsburgh Steelers and Cleveland Browns play against each other for the second time in Week 14. So, that’s two divisional matchups in three weeks. Whereas, many other divisional rivals have at least a month or two in-between games.
Week 12’s matchup marks the 146th time these divisional foes have faced each other. Currently, the Steelers hold the advantage in this series with an 81-63-1 record. Pittsburgh is also 6-4 in the last 10 meetings. They split the matchups last year, with each team winning at home. The Browns are 4-1 in their last five home games versus the Steelers.
Can Cleveland continue their success at home against Pittsburgh or will the Steelers win a second game in a row over the Browns?
Detroit Lions vs. Indianapolis Colts
This Week 12 matchup against the Indianapolis Colts, will mark the fourth and final game for the Detroit Lions against the AFC South. Furthermore, the Lions will have played all four teams within a five-week stretch. In fact, this will be the third straight AFC South game for Detroit.
As for the Colts, this will be their final NFC North game, but their four matchups are spread out over the season.
The Lions and Colts have played against each other 44 times. Indy holds the slight advantage with a 22-20-2 record. The Colts are also 5-1 in the last six meetings between these two teams. However, the Lions are 3-3 on the road versus the Colts.
Can Detroit snap Indy’s recent winning streak or will the Colts continue to tame the Lions?
San Francisco 49ers vs. Green Bay Packers
This Week 12 NFC clash reminds us of the old days when these two teams were at the top of the conference. Well, if things go according to expectations, these two NFC squads will be battling for one of the top NFC seeds this year.
Green Bay has a little extra motivation for this week’s game. For, it was the 49ers who vanquished the Packers in the Divisional Round of the Playoffs last year by the score of 24-21.
In fact, San Francisco is 4-2 in the last six head-to-head meetings. This will be the first regular season meeting between these two teams, in Green Bay, since 2018. The Packers are 1-3 in their last four home games versus the 49ers.
Can Green Bay get revenge for two straight Playoff defeats against San Francisco or will the 49ers continue to flex on the Packers?
Philadelphia Eagles vs. Los Angeles Rams
This Sunday Night Football matchup pits two teams hoping to make it to the Playoffs, which means this game adds extra importance due to Conference record being one of the major tiebreakers. This SNF game will mark the 45th time that the Philadelphia Eagles and Los Angeles Rams have played against each other.
Currently, the Eagles hold a slight advantage in this series with a 23-20-1 record. Additionally, Philadelphia has won seven of the last eight head-to-head games. Making matters even more depressing for Rams fans is the fact that the Eagles have won five straight road games in this series.
With the Rams battling for a Wild Card spot, another loss to Philly could put them further back in the race. However, a loss for the Eagles could damage their chances at claiming the NFC East crown as they’re expected to be in a neck-and-neck race with the Cowboys.
Will the Rams break their losing streak to the Eagles or will Philly continue to soar high in Los Angeles?
Baltimore Ravens vs. Los Angeles Chargers
Sometimes, the NFL schedule makers completely miss the mark like with the Steelers and Browns playing against each other twice in three weeks. Or, even worse, the Steelers entire second half schedule with the majority of their divisional games taking place over the last few months of the season. This scheduling is unlike anything seen before.
Then, there are times when the schedule makers hit a bullseye. And, that’s exactly what they did by giving us a Monday Night Football game between the Baltimore Ravens and the Los Angeles Chargers. Even if the Bolts aren’t that good, or have a losing record, this brother vs. brother matchup will still make for compelling television.
This MNF game marks the third time that these two coaches have competed against each other. The first came in a 2011 Thanksgiving game. The Ravens won that matchup 16 to 6. The second time they squared off was in Super Bowl XLVII and Baltimore won that game 34-31. So, this means that John Harbaugh and his Ravens are 2-0 against Jim Harbaugh. Can they make it 3-0 against Jim and the Chargers?
Baltimore and Los Angeles have played against each other 15 times. The Ravens are 4-1 against the Chargers in the last five meetings. These two teams faced each other last November, where Baltimore won on the road by the score of 20-10. The Ravens are 4-1 in their last five road games in this series.
Can the Chargers help Jim Harbaugh beat his older brother John Harbaugh and the Ravens?
NFL Week 12 Predictions
As we get closer to the Week 12 of the 2024-25 NFL season, we will provide a variety of free NFL picks designed to help you make well-informed and strategic decisions. Our experts carefully analyze these NFL picks, leveraging the latest data, trends, and insider insights. Here are some of the categories that we’ll cover with our NFL Week 12 predictions:
- Best Pick Against the Spread (ATS): Our ATS pick highlights the best bet for teams expected to cover the point spread, providing valuable insights into which matchups offer the most potential for a profitable wager.
- Best Moneyline Pick: For those who prefer betting on outright winners, our moneyline pick offers a top selection based on a comprehensive analysis of team performance, player statistics, and other critical factors.
- Best Total Pick: Our total pick focuses on the over/under, helping you identify games where the total points scored will likely go over or under the set line. Detailed statistical models and game scenarios back this pick.
- Best Player Prop: Dive into individual player performances with our best player prop pick. Whether it’s passing yards, touchdowns, or receptions, we pinpoint standout player prop bets that offer excellent value.
- Best Team Prop: Explore team-centric bets with our best team prop pick. These can include total team points, turnovers, or specific team milestones, providing a broader range of betting opportunities.
NFL Week 12 Best Bets
In addition to breaking down the featured games of the week, we’ll also provide you with our best NFL Week 12 bets. You can place individual wagers on these NFL best bets or you can combine them for a potential NFL Week 12 parlay.
