2022 San Francisco 49ers Win Total Odds and Picks

The San Francisco 49ers are one of the most storied franchises in the NFL, and they are always a team that attracts a ton of attention. San Francisco nearly made it to the Super Bowl in 2021, and they have been in that situation recently in the past.

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There are numerous ways to go about placing your bets on the 49ers in 2022, but betting on the total number of regular NFL season wins is one of those options. The regular season win total lines have been set, and those lines will remain open throughout the year.

San Francisco 49ers Regular Season Win Total Betting Lines

Over 9.5 (-145)

Under 9.5 (+125)

Last Season

The San Francisco 49ers finished the 2021 NFL season with an overall record of 10-7, and that was good enough for third place in the NFC West. Despite having some difficult games in the NFC West, the 49ers were still able to reach the postseason.

San Francisco then got extremely hot in the postseason as they won two games in upset fashion. The 2021 playoff run for the 49ers ended in the NFC Championship Game with a loss to the Los Angeles Rams.

NFL Moneyline Odds

49ers Key Losses Heading Into 2022

The San Francisco 49ers have done an outstanding job of protecting their top assets, and this roster is going to be similar to what the team looked like in 2021. Guard Laken Tomlinson has moved on to the New York Jets, and defensive tackle D.J. Jones has moved on to sign with the Denver Broncos.

2022 San Francisco 49ers Team Preview

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The San Francisco 49ers are going to be rolling with a new quarterback in 2022 as Trey Lance is expected to take over that job. San Francisco is still going to be a team that wants to run the football as that strategy has worked in the past.

The defensive line should once again be a huge strength for this team as well. San Francisco will be a team that wants to slow the game down and win it by being physical.

NFL Moneyline Picks

2022 San Francisco 49ers Schedule

The San Francisco 49ers will once again play six games against NFC West opponents, and those will be some difficult games. San Francisco will also have games against every member of the AFC West and NFC South Divisions.

The final three games on the schedule for the 49ers includes a Week 1 game at the Chicago Bears and home games against the Miami Dolphins and Washington Commanders.

2022 49ers Regular Season Win Total Prediction

The San Francisco 49ers snuck up on everyone in getting to the NFC Championship Game a season ago, but they won’t be able to do any sneaking around in 2022. San Francisco is a team that is loaded with talent, and they should be one of the better teams in the league.

Getting to 10 wins is never easy, but San Francisco is good enough to get the job done. Take the 49ers over 9.5 wins at -145.

Pick: San Francisco 49ers Over 9.5 Wins (-145)

Read our 2022 Panthers team preview and 2022 Vikings team preview.

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Kyle Parker
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