NFL Week 4 Point Spread Predictions

We have already reached week 4 of the NFL season and it has been a crazy few weeks to begin the year. There is a full slate of NFL games set for week 4, including a match-up set to take place in London.

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Betting on point spreads continues to be a good option when betting on the NFL and you can find some good bets to make in week 4. Here are five of the best NFL week 4 point spread picks to consider.

Chicago Bears at New York Giants

Bears vs. Giants Predictions

Best Bet: Bears +3.5

A pair of surprising 2-1 teams are set to meet in the Meadowlands in week 4 for what should be an interesting game. Chicago has been able to win games with defense, while the Giants have been a pleasant surprise on offense.

The Giants are the betting favorites in this NFL game, but it’s not going to be easy to score against the Chicago Bears. With so much uncertainty surrounding the Bears and Giants, the best play is to take the points and bet on Chicago.

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Minnesota Vikings at New Orleans Saints

Vikings vs. Saints Predictions

Best Bet: Vikings -2.5

The Vikings and Saints are not in the same division, but they have built up a nice rivalry through the years. Both teams have been solid to begin the 2022 season, even if neither team is expected to make a deep playoff run.

New Orleans has the ability to be one of the better defensive teams in the league, but stopping the Vikings won’t be easy at all. Bet on the Vikings as they roll to a big win over the New Orleans Saints in this one.

Seattle Seahawks at Detroit Lions

Seahawks vs. Lions Predictions

Best Bet: Lions -5.5

The Detroit Lions appear to be much improved in 2022 and they have an offense that can light it up in a hurry. Detroit blew a late lead to Minnesota in week 3, but they are still a team that can rack up some wins.

Seattle has struggled without Russell Wilson leading the way and this is going to be a long day on offense for the Seahawks. Bet the Lions as they pick up a convincing win in this one.

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Los Angeles Chargers at Houston Texans

Chargers vs. Texans Predictions

Best Bet: Chargers -5

The Los Angeles Chargers were just embarrassed in week 3 by the Jacksonville Jaguars and they will be out for revenge this week. That’s bad news for a Houston Texans team that has actually been better than expected in 2022.

Houston has been solid on defense so far this season, but they have an offense that struggles. The Chargers are going to bounce back with a big offensive performance and that will be the difference in this one.

Take the Chargers -5.0 as they roll to a big win.

Kansas City Chiefs at Tampa Bay Buccaneers

Chiefs vs. Buccaneers Predictions

Best Bet: Chiefs -2.5

The Chiefs and Buccaneers meet on Sunday Night Football for a rematch of the Super Bowl from two seasons ago. Both squads could be in the mix again this NFL season, but each team also suffered a loss in week 3.

Tampa Bay is dealing with a lot of injuries on offense and it’s hard to see them scoring enough points to win this one. Kansas City has some flaws of their own, but Patrick Mahomes and company will take over in this one.

Take the Chiefs -2.5 on Sunday night.

Read our point spread betting guide to learn more about this bet type.