College Football Week 4 Point Spread Picks

Week 4 of the NCAAF season brings a ton of conference match-ups, as most teams are done playing non-conference games. This is when the activity really starts to heat up throughout the country and there are some big games on the schedule.

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Finding the best games to watch is enjoyable, but it’s more important to find good betting opportunities. Here are five of the best CFB week 4 point spread picks to target.

Baylor Bears at Iowa State Cyclones

Baylor vs. Iowa State Predictions

Best Bet: Baylor +2.5

Big 12 Conference rivals clash when Iowa State hosts Baylor as a 2.5-point favorite. Iowa State has been a pleasant surprise this NCAAF season, as they come into this game with a perfect 3-0 record.

Baylor’s lone loss of the season was in overtime on the road at BYU and this team is loaded with offensive talent. Iowa State will try to slow down the tempo in this game and win it by running the football a ton.

This game will be tight, but Baylor is going to pick up a big road win in this one.

College Football ATS Odds

Duke Blue Devils at Kansas Jayhawks

Duke vs. Kansas Predictions

Best Bet: Duke +9

A pair of surprising 3-0 teams will meet up in Lawrence, as the Kansas Jayhawks host the Duke Blue Devils. Kansas is a big favorite for the first time in a decade over another Power 5 school, but they will face a challenge in this one.

Duke has already gone on the road and picked up a win over Northwestern and the Blue Devils feature a dominant defense. Kansas is scoring 53 points per game, but they still need to play better on the defensive end.

The spread for this game is too large, and taking the nine points is the best way to go.

Florida Gators at Tennessee Volunteers

Florida vs. Tennessee Predictions

Best Bet: Florida +11

Florida and Tennessee resume their terrific rivalry on Saturday when they meet up for a huge game in the SEC. The Gators have dominated this NCAAF series in recent seasons, but they are massive underdogs in this one.

Tennessee is scoring 52 points per game this season, while Florida is right around 25 points per game. The Volunteers also have the better defense, but the Gators have some athletes on both sides of the ball.

Tennessee can’t lose this game at home, but this rivalry always delivers. Take the 11 points and bet on Florida to cover the spread on the road in a tough environment.

College Football ATS Picks

Notre Dame Fighting Irish at North Carolina Tar Heels

Notre Dame vs. North Carolina Predictions

Best Bet: Notre Dame +1

The Notre Dame Fighting Irish look for a second straight win when they travel to Chapel Hill to play against the North Carolina Tar Heels. North Carolina is a perfect 3-0 on the year and they are scoring over 51 points per game.

The Fighting Irish are scoring just 18 points per game, but they have the defense to be able to win this game. Now that Notre Dame has found some success, it should set up for a nice run for the veteran group.

This could be one of the better NCAAF week 4 games, but Notre Dame will survive on the road and pick up the win.

Oregon Ducks at Washington State Cougars

Oregon vs. Washington State Predictions

Best Bet: Oregon -6.5

The 2-1 Oregon Ducks travel to Washington State on Saturday afternoon for a match-up with the 3-0 Cougars. This spread looks a little tight on paper, considering what Oregon just did in week 3.

Oregon picked up a 41-20 win over number 12 BYU in week 3 and this offense comes into this game with a ton of momentum. Washington State was able to upset Wisconsin in week 2, but the Cougars have also played two bad teams.

The Ducks are clearly the more talented team and they won’t have any trouble winning this game by a touchdown or more.