Week 10 of the 2025-26 NFL season has some exciting matchups for fans and bettors alike. However, there’s also some big odds-favorites and very few Underdogs worthy of consideration for our Week 10 parlay.

After crossing the midpoint of the season, a few teams are starting to establish themselves as Super Bowl favorites. You will notice that three of those teams have made our NFL parlay picks this week like the Buffalo Bills, Detroit Lions and Tampa Bay Buccaneers.

With that said, parity has made NFL betting tricky at times. Fortunately, NFL parlays are one way to maximize betting value when the boards seem difficult to decipher.

After looking at the Week 10 slate of games, we have a handful of NFL picks to add to our parlay card. Let’s take a closer look at the best NFL parlays for Week 10.

NFL Picks and Parlays

Team	Odds	Payout Per Leg
Buffalo Bills	-510	$19.61
Detroit Lions	-430	$47.43
Tampa Bay Buccaneers	-150	$145.72
Jacksonville Jaguars	-122	$347.13

Yes, we are going with four NFL teams that are favored this week. Heading into Week 10, Favorites are 94-40-1 which is a 70.1% winning percentage. Three of these teams are favored on the road. Away Favorites are 39-18-1 over the first nine weeks, which breaks down to a 67.2% winning percentage.

The Jaguars have the lowest odds to win, but they were Underdogs coming into the week. So, we can clearly see that the betting public is jumping on them as they will face a Texans team without CJ Stroud.

With that said, make sure you continue to monitor the NFL odds throughout the week as they could shift as we get closer to kickoff, which will impact your total payout for this parlay card. For more NFL advice and picks, check out the best handicapping membership in the industry.

NFL Parlay Picks

The following is our best parlay NFL picks for Week 10:

NFL Parlay Pick 1:  Buffalo Bills (-510) vs. Miami Dolphins

This AFC East matchup is a tale of two teams. The Buffalo Bills (6-2) have won two games in a row and are pushing the Patriots for the divisional lead. The Miami Dolphins are a dumpster fire at 2-7 and appear well on their way to a rebuild this offseason.

Miami’s success in Week 8 against the Falcons was wiped away in Week 9 when they were demolished by the Ravens at home by the score of 28-6.

Since Josh Allen came into the league, the Bills are 14-1 SU in the last 15 games against the Dolphins which includes winning seven games in a row. Miami hasn’t defeated Buffalo since September 2022.

These two teams played in Week 2 and the Dolphins made it close as Buffalo edged Miami 31-21 and it was due to a late score to put this contest away. I expect things to be different this weekend.

Look for Buffalo to come in with an edge as they just beat their nemesis Kansas City 28-21. More importantly, the Bills look like a different team since their Week 7 Bye.

Buffalo has outscored their last two opponents (Chiefs, Panthers) 68 to 30. They crushed Carolina 40-9 in Week 8, which the Panthers just went and beat the Packers in Green Bay last Sunday.

The Bills will lean on their rushing attack that ranks no.1 in the league even if Cook is out. Buffalo averages 161.5 ypg and the Dolphins allow 145.6 ypg which is the third most in the league.

Buffalo is 5-1 SU in their last six games at Miami. The Dolphins are 1-7 SU in their last eight AFC games.

NFL Parlay Pick 2:  Detroit Lions (-430) vs. Washington Commanders

Where Buffalo has owned the Miami Dolphins over the last seven to eight seasons, this matchup is more so about the Washington Commanders (3-6) being without star QB Jayden Daniels. Marcus Mariota will get the start this week and probably for the rest of the season.

The Detroit Lions (5-3) are coming off an embarrassing home loss to division rivals the Minnesota Vikings and will be angry this week.

Every time this season, the Lions have rebounded from a loss with a big win. Detroit dropped their opener to the Packers and then turned around to demolish the Bears in Week 2 by the score of 52-21.

In Week 6, they lost to the Chiefs. The next week, Detroit bounced back to smash one of the NFC’s top teams in the Buccaneers by the score of 24-9. That’s a combined 76 to 30 score following a loss for the Lions.

In this series, Detroit is 6-2 SU and 6-2 ATS in the last eight head-to-head matchups with Washington. Furthermore, the Lions are 10-2 SU in their last 12 road games and 12-3 SU in their last 15 NFC games. The Commanders are o-5 ATS in their last five NFC games and 1-5 SU in their last six overall contests.

Washington has the fourth worst pass defense that allows 253.6 ypg. The Lions come in averaging 225.6 ypg in the air and are 9^th in rushing, as well. This is a balanced offense that can beat you a number of ways. Look for Detroit’s duo of Gibbs and Montgomery to find success on the ground, while Jared Goff smashes Washington’s porous secondary.

NFL Parlay Pick 3: New England Patriots vs. Tampa Bay Buccaneers (-150)

This is definitely one of the top games in Week 10 as the AFC East leading New England Patriots (7-2) take on the NFC South leading Tampa Bay Buccaneers (6-2).

New England has been a surprise this year for most people. I, however, picked them to fight for a Wild Card spot due to the evolution of Drake Maye who has been great this season to date. I still believe Buffalo will catch the Patriots and take the division but New England should still get into the Playoffs.

With that said, I do like the Bucs in this matchup for a few reasons. Most notably, Tampa Bay is coming off a Bye Week which will greatly help them as they’ve been banged up. Additionally, it gives them an extra week to prepare.

Did you know that teams coming off a Bye Week are 10-4 SU in their next game? That bodes well for the Bucs and further supports this NFL parlay pick. It also bucks the trend where the Patriots have a 7-3 SU record in 10 all-time meetings against Tampa Bay.

Whichever team can establish their ground game should win this game. Both defenses rank at the top of the league for stopping the run. In fact, New England is no.1 against the run at 75.4 ypg. However, they do give up 223.6 ypg in the air and I expect Baker Mayfield to crush the Patriots secondary.

Last week, New England allowed Michael Penix Jr. to throw for 221 yards and three touchdowns. If they give Mayfield that kind of success, then this game will be a blowout.

The Bucs are 7-1 SU in their last eight AFC East games, 4-1 ATS in their last five AFC games, and 6-1 ATS in their last seven November games. At home, I give the well-rested Bucs an edge and the win. But it will be close!

NFL Parlay Pick 4: Jacksonville Jaguars (-122) vs. Houston Texans

These AFC South rivals will clash for a pivotal divisional matchup. And, the Jacksonville Jaguars (5-3) are in the ideal position to pick up the win against the Houston Texans (3-5). This is due to the Texans being without starting QB C.J. Stroud who’s out with a concussion.

Now, it won’t be easy because Houston has one of the best defenses in the league. The Texans are no.1 in scoring (15.1 ppg) and yards allowed (267.4 ypg). They’re also 4^th in the NFL with 1.6 takeaways per game.

With that said, it’s hard to have confidence in Davis Mills against a hungry Jaguars team trying to keep pace with the Colts for the division lead and to stay ahead of the Chiefs for the final Wild Card spot.

These teams are 3-3 in their last six head-to-head meetings. Yet, the Jaguars are 2-1 in their last three trips to Houston. Furthermore, Jacksonville is 4-1-1 ATS in their last six games versus the Texans. Additionally, the Jags are 4-0-1 ATS in their last five divisional games. Houston is 1-4 SU in their last five November games.

The Jaguars added Jakobi Meyers at the trade deadline which will help to open up a passing game that seemed anemic without Travis Hunter last week. Meyers is capable of excelling at the no.2 WR position and will put pressure on the Texans.

Plus, let’s not forget that Houston will struggle with their backup QB running the offense. I see more turnovers, three-and-outs, and less time controlling the ball. This will equate to the Jags having more possessions on offense, and the potential to score more points in this matchup.

It will be close, but Trevor Lawrence, BJT, and Meyers will edge out Houston this Sunday.

NFL Parlay Total Payout

• Buffalo Bills (-510)
• Detroit Lions (-430)
• Tampa Bay Buccaneers (-150)
• Jacksonville Jaguars (-122)

Although three of these four picks are road teams, the matchups are favorable to those teams based on talent, playmakers and injuries. The Jaguars and Lions are facing teams without their starting QBs in the Texans (no Stroud) and Commanders (no Daniels) respectively. These backup QBs will struggle.

The Buccaneers have a tough challenge at home, but they’re coming off a Bye Week which means they had extra time to rest and prepare. Lastly, Josh Allen has owned the Miami Dolphins in his career.

The Bills are 14-1 SU in their last 15 games against the Dolphins. Allen’s best numbers over his brilliant career has come against Miam. I expect that to continue in Week 10.  

If you take all four legs of this NFL parlay card, then you would score a $347 payout. That’s nearly a 3.5x your initial investment. Our two favorite picks are the Lions and Bills defeating their vastly inferior opponents.

Remember, to wager on this parlay card, you will need to check out the best sports betting sites and take advantage of any optimal lines, which means some line shopping could be greatly beneficial.

If you are loving these NFL parlay picks, then check out our College Football parlays of the week and double down on this weekend’s gridiron action.