Week 12 of the 2025-26 NFL season is shaping up to be a crucial week down the stretch run of the regular season. Will some of these important games make our parlay card?

Week 11 was a big hit for us and our parlay ticket. We nailed a four-leg parlay that paid out 2x on our initial investment. The Ravens, Texans, Packers and Cowboys all won their respective matchups and helped us pad our bankroll.

This week, we’re looking at a few matchups that feature massive spreads and one or two Underdogs covering their lines while threating to win. Of our Week 12 parlays picks, we have a handful of Super Bowl hopefuls on our list.

With that said, parity has made NFL betting tricky at times. Fortunately, NFL parlays are one way to maximize betting value when the boards seem difficult to decipher.

After looking at the Week 12 slate of games, we have a handful of NFL picks to add to our parlay card. Let’s take a closer look at the best NFL parlays for Week 12.

NFL Picks and Parlays

Team	Odds	Payout Per Leg
Baltimore Ravens	-950	$10.53
Detroit Lions	-575	$29.75
Philadelphia Eagles	-170	$106.07
Indianapolis Colts +3.5	-120	$277.80

Yes, we are going with three NFL teams that are favored this week. Heading into Week 12, Favorites are 115-48-1, which is a 70.6% winning percentage.  In Week 11, the Favorites went 11-4 SU.

Furthermore, two of these four picks are favored as road teams. Away Favorites are 48-22-1, which breaks down to a 67.6% winning percentage. Road Favorites went 5-2 in Week 11.

Over the last few weeks, we’ve gone 10-2 in our NFL parlay picks, which led to a winning ticket (4-0) in Week 11 and two 3-1 records for Weeks 9 and 10.

With that said, make sure you continue to monitor the NFL odds throughout the week as they could shift as we get closer to kickoff, which will impact your total payout for this parlay card. For more NFL advice and picks, check out the best handicapping membership in the industry.

NFL Parlay Picks

The following is our best parlay NFL picks for Week 12:

NFL Parlay Pick 1:  New York Jets vs. Baltimore Ravens (-950)

The Baltimore Ravens come into this matchup having won four games in a row and now sit 5-5 on the season. They’re just a game back of the Steelers for first place in the division. It’s a remarkable turnaround that coincided with the return of Lamar Jackson.

The Ravens have won three in a row with Jackson back at the helm. Although things haven’t been perfect for Baltimore since Lamar’s return, they’re facing a bad New York Jets team and favored by 13.5 points to win. That’s tied with Seattle over Tennessee for the largest spread of Week 12.

The Jets are 0-7 SU in their last seven trips to Baltimore. Making matters worse for New York is the fact that they’re just 1-10 SU in the last 11 overall games against the Ravens. And, if you are thinking of backing the Jets and the points, New York is 2-11 ATS in their last 13 games versus the Ravens.

In other words, Baltimore has dominated this series over the last decade plus, and they will dominate on the field this weekend, as well.

Both teams like to run the ball but the Jets allow 130.9 rushing yards per game, and the Ravens rank 4^th with an average of 142.0 ypg. So, this week’s matchup definitely favors King Henry and Jackson running the ball.

New York gives up the highest sack rate in the league. So, even with Tyrod Taylor taking over as the starting QB, a disappointing Jets team will face waves of pressure from the Ravens.

I think Baltimore will end up winning this game by at least two touchdowns as they try to take command of the AFC North.

NFL Parlay Pick 2:  New York Giants vs. Detroit Lions (-575)

Don’t look now, but Detroit has a Top 10 defense to go along with their Top 10 offense. Normally, that would equate to one of the best records in the NFL. However, Detroit is just 6-4 on the season as they laid an egg against the Eagles last week when they lost 16-9.

The Lions have been alternating between wins and losses. Yet, those losses have come against top tier teams like the Eagles and Chiefs. Along with a divisional defeat against Minnesota.

With that said, Detroit has beat the inferior teams on their schedule. And, the Giants are an inferior team with a 0-6 on the road this year and 0-10 SU in their last 10 away games. The Lions are 3-1 SU at home this season and 14-4 SU in their last 18 games played at Ford Field.

Dipping further into despair, New York is 1-15 SU in their last 16 NFC games and 1-4 SU in their last five meetings against Detroit.

The Lions are going to feast on New York’s no.30 run defense that allows 149.9 ypg. Detroit ranks 7^th in running the ball as they average a tick over 130 yards per game. Look for Gibbs to have a monster performance.

While Dart should return for the Giants, he won’t be enough. Additionally, he’s going to be under pressure all game long as the Lions are 4^th in sack rate at 9.01%. One more thing to note, the Giants average the 6^th most penalties per game at 7.7 flags.

The Lions know it’s crunch time and they will put things in another gear as they claw their away to the top of the NFC North. That starts with a double-digit win over the Giants.

NFL Parlay Pick 3: Philadelphia Eagles (-170) vs. Dallas Cowboys

The Eagles are fortunate to be sitting at 8-2 on the season and positioned as the no.1 seed in the NFC. They should’ve lost the season opener to the Cowboys but Dallas crumbled in the final frame and literally dropped a victory.

Unfortunately, I don’t see Dallas avenging that loss this weekend even though they’re playing at home. The Eagles have come out of their Bye Week looking like the Super Bowl champs. They’ve beat the Packers and Lions in consecutive weeks.

What has really stood out from those two wins is that Philly’s defense has appeared to regain their dominance from last year. The Eagles allowed seven points to Green Bay and nine points to Detroit. While their offense didn’t impress at all, it’s going to be hard for any team to beat them with a defense playing like that.

The Eagles are 4-1 SU in their last five games against Dallas and 5-1 SU in their last six NFC East contests. Furthermore, Dallas is just 4-10-1 SU in their last 15 games as the underdog.

The Eagles’ offense should have a great game against one of the league’s worst defenses. Don’t let Dallas’ performance against a bad Raiders team fool you. The Eagles are better on both sides of the ball and will exploit a terrible Cowboys’ defense that allows 29.3 ppg (31^st), 381.3 total ypg (30^th), 249.9 passing ypg (30^th), and 3.4 TDs per game (31^st).

If you have any Philadelphia players on your fantasy team, start them all! And, take the Eagles to soar to victory in the Big D on Sunday!

NFL Parlay Pick 4: Indianapolis Colts +3.5 (-120) vs. Kansas City Chiefs  

What would you say if I told you that the Colts are 15-4 SU and 14-5 ATS in their last 19 games against the Chiefs? How about 8-1 SU in their last nine AFC games and 5-1 SU in their last six overall games? What about Indy coming off a Bye Week and slotting in as the no.2 seed in the AFC as of Week 12?

In other words, I think the sportsbooks got this spread wrong. Sure, KC is still a dangerous team with the best player in Patrick Mahomes. Yet, the Colts have the better overall team despite the lesser QB of the two.

Indy has a sizable advantage in the trenches which will be the difference in this game. Watch for the Colts offensive line to protect Daniel Jones so that he can find open receivers and for Jonathan Taylor to have plenty of running lanes. The Colts are no.3 running the ball and average 145.3 ypg.

KC has lost two games in a row and are in desperate need of a win at home where they are 4-1 SU on the season and 17-1 SU in their last 18 games.

I think the Chiefs can edge out the win but they won’t cover the spread. KC has averaged 20.33 ppg in their last three against the Colts, while Indy has put up 17.33 ppg. Furthermore, the Chiefs are 0-7 ATS in their last seven November games which includes both of their games this month already (Bills, Broncos).

Give me the Colts to cover and push KC to their limits.

NFL Parlay Total Payout

• Baltimore Ravens (-950)
• Detroit Lions (-575)
• Philadelphia Eagles (-170)
• Indianapolis Colts +3.5 (-120)

The Ravens and Lions are double-digit favorites facing vastly inferior New York teams who happen to share the same stadium for home games. Both Baltimore and Detroit are playing at home and are just too good for their opponents to overcome.

The Eagles are 4-1 SU in their last five against the Cowboys and have already defeated them this season. Furthermore, they look like the Super Bowl champs again in their last two games following the Bye Week. That defense is scary.

Lastly, the Colts are just too good to be a 3.5-point underdog. Especially since the Chiefs are just 5-5 on the season and Indy has gone 15-4 SU and 14-5 ATS in their last 19 head-to-head meetings.

If you take all four legs of this NFL parlay card, then you would score a $277.80 payout. That’s nearly a 3x your initial investment. Our favorite pick of the weekend is the Baltimore Ravens. They are going up against a lame duck team with QB issues in the New York Jets.    

Remember, to wager on this parlay card, you will need to check out the best sports betting sites and take advantage of any optimal lines, which means some line shopping could be greatly beneficial.

If you are loving these NFL parlay picks, then check out our College Football parlays of the week and double down on this weekend’s gridiron action.