The first NFL parlay of the season didn’t hit, but the logic was solid enough. My week one NFL parlay picks ultimately went 2-2, with KC failing to take down the Chargers, and Chicago blowing a 17-6 lead at home in a loss to the Vikings.

Hopefully I can work some magic going into week two, as I’ve got some new NFL parlays picks to consider. As usual, you don’t have to copy my exact parlay when you look to place your wagers at your favorite NFL betting sites, as you can opt to decide which of my NFL Week 2 picks you like the most.

You can also opt to target some of these bets in a different manner. For example, if I call for a ML upset, one option is to bet on that team to beat the spread. I also would consider our Week 2 NFL predictions for additional ideas before finalizing your bets.

That said, I’ve got a four-pack of NFL parlay picks that I love. Let’s see why these stand out going into week 2, and why combining them together is a good idea.

NFL Picks and Parlays

Monitor the NFL odds throughout the week. As the odds change, the parlay payouts will change as well. 

Team	Odds	Payout Per Leg
Detroit Lions	-300	$35.71
Jaguars vs. Bengals Over 49	-110	$159.09
Los Angeles Rams	-245	$264.84
Dallas Cowboys	-260	$405.17

YThis is not as aggressive of an NFL parlay as I had last week, but it’s one full of likely winners. Obviously the odds are very favorable for three of the teams here, but I also love the logic behind the bets.

You can attack the respective team’s point spreads if you want a bit more value, but I love the idea of these exact bets and turning $100 into over $400.

Of course, beyond just pivoting from ML bets to some point spreads, you can throw in a steep underdog if there’s one you feel good about. I went over my favorite week 2 NFL underdogs already, so removing one of the above bets in favor of an upset is totally viable – albeit far riskier.

Still, the end game is to win. Turning $100 into $400 won’t get you rich this week, but it could quadruple the money you’re laying down to seek some profit. Need more reasoning? Let’s dive into why I like each pick this week.

Of course, I’m just one voice here. The NFL odds are subject to change on any of my parlay picks, too, while you can get extra advice by leaning on the top handicappers out there.

NFL Parlay Picks

The following is our best parlay NFL picks for Week 2: 

NFL Parlay Pick 1: Detroit Lions ML (-300)

The Detroit Lions are one of the best NFL teams out there, but they admittedly didn’t really look like it in a lopsided week one loss to the rival Green Bay Packers.

I knew going in that Detroit might be at risk of getting taken down, as they were obviously in a tough spot on the road, but they also endured a ton of change over the course of the off-season. Not only did they lose both their offensive and defensive coordinators, but star center Frank Ragnow also opted for retirement.

The Lions felt all of those departures, as they were sluggish offensively and even gave up 27 points on the defensive end. Just like that, a team that had legit Super Bowl aspirations ate half of the loss count it suffered all of last year.

But there’s still hope for the Lions. Not only do they have a bounce-back matchup against a worse team in the Chicago Bears, but history will propel them toward a much-needed win. Teams getting off to 0-2 starts do not often make the NFL playoffs, and falling further behind in the NFC North would hurt Detroit’s chances of making a run later in the year even more.

I expect the Lions to dig deep and get the win here. Besides, I haven’t even gotten into how bad Caleb Williams looked at times during a week one collapse against Minnesota. The Lions also face former OC Ben Johnson, who they obviously know quite well. Both sides will know each other, but I give the edge to Dan Campbell and the Lions at home in what feels like a must-win game.

NFL Parlay Pick 2: Jaguars vs. Bengals Over 49 (-110)

Three of my week 2 NFL parlay picks are thick moneyline wagers, but this one targets a pretty tame game total for the Jacksonville Jaguars vs. Cincinnati Bengals contest. I say tame because we know how gifted both offenses are, and the 49 total is equal parts accurate and low.

This feels like a bit of a discount. The Jags are coming off of a strong week one performance, but Trevor Lawrence and Brian Thomas Jr. failed to connect on six of seven targets, so a team that put up 26 points left a lot of production on the field.

Jacksonville looks like a dynamic unit, though, and if the Bengals defend anything close to what they did a year ago, it’s likely the Jaguars will have success putting points on the board. On the other side, Cincy didn’t explode against Cleveland in week one (17 points), so I expect them to get it going more in a softer matchup against Jax in week two.

Ja’Marr Chase and most of the Bengals passing attack was awfully quiet last week, and given the talent and system this squad has, that simply can’t possibly last for long. With both sides coming together, 49 total points feels like a low bar. I’ll be hammering the Over.

NFL Parlay Pick 3: Los Angeles Rams ML (-245)

Next up we have the Los Angeles Rams. Their individual price is just -245 and they don’t boost the parlay that much, but every piece counts. Whether you include them in your week 2 NFL parlay, attach them solo, or target them to cover their spread, I like them a lot.

The Rams won a close battle with the Houston Texans last week, which didn’t tell us a lot about them offensively, but their defense sure looked good. The good news is quarterback Matthew Stafford’s back held up, and we know this offense is loaded with star power and plenty dynamic.

L.A. will be the far more talented team when they head east to take on the Tennessee Titans. The Titans actually played the Denver Broncos better than expected last week, but they don’t have much for bettors to fear.

Rookie quarterback Cam Ward will get there eventually, but this is his second tough test in a row to begin his career. He simply doesn’t have the talent around him to overcome tough matchups just yet, and I’ll be betting against him doing so in week two.

NFL Parlay Pick 4: Dallas Cowboys ML (-260)

Lastly, I am very big on targeting teams that have major incentive and are in dire straits. The Dallas Cowboys fit the bill going into week two, as they lost in week one and are staring an 0-2 hole in the face.

I didn’t think much of the ‘Boys going into the 2025 NFL season, but they held up decently on the defense against the defending champs, and their offense even was solid. More importantly, a previously dormant rushing attack actually seemed to have life.

It was just one week, but if Dallas can hang with the Eagles, it stands to reason that they can fend off a New York Giants squad that was utterly lifeless in a 21-6 week one loss to the Commanders.

Dallas has more offensive firepower and has the benefit of playing at home in a crucial game that could very well decide if they have a shot at sniffing the playoffs this season.

NFL Parlay Total Payout

As noted, this specific parlay lacks elite upside, but it’s four rock solid bets strung together, and I don’t know about you, but I’d gladly take $400 on a $100 bet. You do still need four legs to hit, so my advice is to shop around for the best possible price at your favorite sports betting sites. Depending on which sportsbooks you call home, the price could be a tad better.

If you’re not loving the NFL odds you find for these bets, you can opt to target them in isolation, or switch up the parlay a bit. One option is to convert all of the ML bets into point spread bets. If you do this, you could win back a whopping $1,123 for every $100 you risk.

Those respective spreads aren’t even egregious, either. If you agree with me that the Cowboys, Rams, and Lions are likely to win, I doubt it would be hard to convince you that they all could win by 5-6 points as well.

If you are loving these NFL parlay picks, then check out our College Football parlays of the week and double down on this weekend’s gridiron action.