Week 16 arrives on Thursday night, as the Seattle Seahawks and Los Angeles Rams face off in the game of the week. That’s arguably the biggest game of the year in the NFC, but there’s another one on Saturday between the Green Bay Packers and Chicago Bears that is almost as good.

The point? Week 16 in the NFL projects to be a ton of fun, as the playoff picture gets more intense with so many good teams jockeying for position en route to a run to this year’s Super Bowl.

NFL betting can be fun, too, especially if you roll with my top week 16 NFL player prop bets. That’s been the case the past two weeks, as my best NFL player props have gone a sparkling 10-0. It literally doesn’t get any better than that when it comes to handing out NFL picks, and the goal is to stay perfect through this week.

If elite NFL player props aren’t enough, stop by our Week 16 NFL predictions for a full breakdown of this week’s pro football betting action.

NFL Player Prop Odds

As noted, we have been on a heater lately. My last 10 NFL player props have hit, which means we went 5-0 for the second week in a row. I was all over Kirk Cousins having a big day on Thursday Night Football against the Tampa Bay Buccaneers, and he converted a -133 prop immediately for us last week.

I was also very high on TreVeyon Henderson cracking 50+ rushing yards (+108), while I went for it all by predicting Brock Purdy would toss three or more scores. He did just that, getting us even more value with an insane +250 price tag at most online sports betting sites.

Amon-Ra St. Brown (+120) was a smash pick to score a touchdown, too, while Tua Tagovailoa wrapped things up in a neat little bow on Monday Night Football by topping 200+ passing yards against the Pittsburgh Steelers (-120).

It was a glorious week, but I’m never satisfied. Let’s get more wins via this week’s best NFL player prop bets. Hit the top plays in the table above, or read on for my reasoning for each bet. Of course, if you want more than just player props for week 16, check out what the top handicappers are cooking up.

NFL Player Props Today

Here’s a breakdown of each prop, analyzing matchups, trends, and key factors to help you make informed NFL bets:

Jaxson Smith-Njigba – Over 7+ Receptions (-122)

Matchup: Los Angeles Rams @ Seattle Seahawks

Let’s get the party started early on Thursday Night Football, where JSN and his Seahawks have a massive divisional showdown at home against the Rams. 

JSN has been a monster on the year, and a remarkably consistent one. He dropped 105 receiving yards on nine catches the first time he faced off with L.A., and he’s topped seven or more receptions in 10 different games in 2025. It’s simple what the guy does.

Seattle could win the second go-around with the Rams, but based off of the matchup, his production in his first tilt with them, and his weekly numbers, he is a really good bet to be heavily involved in the offensive game plan. If that happens, 7+ catches feels like a lock.

A.J. Brown – Over 70+ Receiving Yards (+119)

Matchup: Philadelphia Eagles @ Washington Commanders

Any NFL player prop dealing with A.J. Brown is inherently risky, but he is an explosive wide receiver and after publicly griping about his role, the Eagles have worked hard to get him more involved.

Brown wasn’t needed very much in an easy blowout win over the Las Vegas Raiders last week, so I am looking for him to bounce back in a big way when he takes on the NFC East rival Washington Commanders.

He’s yet to run into the Commanders so far in 2025, but this is a cakewalk matchup on paper, with Washington’s defense allowing the 8th most receiving yards to wide receivers this year. Brown didn’t get there last week, but he had topped 100+ yards in three straight before that.

Brown has big play upside, too, so you don’t need insane volume for him to get there – plus an attractive +119 line makes the risk worth it.

Josh Jacobs – Anytime TD Scorer (-130)

Matchup: Green Bay Packers @ Chicago Bears

One of the safest NFL player prop bets for week 16 has to be Josh Jacobs punching in a touchdown. The Green Bay Packers are admittedly in a bad way at the moment, having lost stud pass rusher Micah Parsons for the year, along with a bunch of other bodies getting banged up.

Christian Watson is one guy the Packers could be forced to play without on Saturday, making it even more important than usual for Jacobs to bring his A-game. He certainly did that last week, as he caught an insane touchdown in the back corner of the endzone, and then displayed his speed with a long touchdown run.

The beauty with Jacobs is he can hit this prop either as a rusher or a receiver, and he also doesn’t need a big play like that to deliver. He’s been Mr. Reliable in the scoring department since joining the green and gold, as he punched in 16 total scores last year and he has 14 more this year.

Jacobs also has at least one touchdown in 10 games this year. On top of that, he faces a Chicago Bears defense that has been a middle of the pack unit against the run in 2025. Oh, and he scored against them just two weeks ago.

In a huge battle for the NFC North, expect Jacobs to deliver on these welcoming -130 odds.

Justin Jefferson – Anytime TD Scorer (+125)

Matchup: Minnesota Vikings @ New York Giants

It’s time to trust in Jettas again. I know it’s tough, especially if you’re game log watching or (gulp) have actually been forced to play this dude in fantasy football leagues. Heck, if you’re a Minnesota Vikings fan this has been an incredibly frustrating season, too.

But that could be changing. Let’s focus on the positives, with the first being the fact that Jefferson was finally featured in the Minnesota offense again this past week. It didn’t translate into real production, but he drew eight targets – his most in four weeks.

Minnesota quarterback J.J. McCarthy is gaining confidence, too. He played solid ball two weeks ago in a shutout win over the Commanders, and last week he went into Dallas and slayed the Cowboys. This week? I think he takes advantage of a really bad New York Giants defense and also officially reestablishes his connection with his alpha wide receiver.

The reason for confidence? It’s two-fold. Beyond McCarthy actually looking competent lately, Jefferson actually scored last week, only to have it called back due to a penalty. Secondly, the Giants are quite awful on defense, ranking 5th worst in receiving yards given up as well as 8th in catching touchdowns allowed.

Jefferson has endured a trying season, but something tells me he’s going to explode down the stretch. It starts this week at a cool +125 against New York.

Tet McMillan – Over 60+ Receiving Yards (+102)

Matchup: Tampa Bay Buccaneers @ Carolina Panthers

My final week 16 NFL player prop has Carolina Panthers wide receiver Tet McMillan topping 60 receiving yards. I know that trusting Bryce Young is never easy, but Carolina is entering a really crucial stretch, as they have two of their last three games against their NFC South rivals, the Tampa Bay Buccaneers.

The first one comes this week, and it’s important to note just how tasty this matchup is. For one, we just saw what Kyle Pitts did to this defense. Heck, even something called a Davis Sills V crushed them. So, yeah, I feel pretty good about Tet McMillan putting up some reasonable numbers.

The magnitude of the game is one thing, as these two sides face off for first place in the division. But beyond knowing these dudes have something to play for, the matchup is sublime with Tampa Bay giving up over 2,100 yards to wide receivers so far in 2025.

Bryce Young is going to have a lot of success in this spot, and it stands to reason that his #1 wide receiver should benefit. McMillan has admittedly not been doing that lately, but he has topped this mark in seven games this year. Considering the matchup and what is on the line, I love him to show up and crush this prop.

Best NFL Player Prop Picks For Week 16

• Jaxson Smith-Njigba – Over 7+ Receptions (-122)
• A.J. Brown – Over 70+ Receiving Yards (+119)
• Josh Jacobs – Anytime TD Scorer (-130)
• Justin Jefferson – Anytime TD Scorer (+125)
• Tet McMillan – Over 60+ Receiving Yards (+102)

Above are my favorite NFL player prop bets for week 16. If you tossed any (or all) of my NFL player props into any NFL parlays the past two weeks, you’d have won all of the money.

That’s fun to do when everything hits, but I do still typically suggest targeting my picks as individual bets just in case things go wrong. Also, make sure you’re using reputable online sportsbooks you can trust, and shop around for the best possible NFL odds to maximize your upside.

If you want the very best week 16 NFL player prop bet, I’d first target Josh Jacobs to score a touchdown. The Packers have a massive game to basically decide the NFC North and Jacobs is as reliable as they come near the goal-line. He has 14 total touchdowns on the year – including two just last week – while he’s found the endzone in 10 different games in 2025.

Of course, I love all of my week 16 NFL player prop bets. Use them together or use them apart. Good luck!

For the NCAAF fans out there, you can also roll with our best College Football parlays of the week for more exciting football betting action.