2024 College Football Week 10 Odds and Predictions

What a week in college football! What a week for our college football experts here at Scores & Stats. More on that in a moment, but the Week 9 matchups of ranked opponents didn’t disappoint. No. 5 Texas survived a scare from No. 25 Vanderbilt. The Commodores almost pulled another upset of a Top 5 opponent but fell to the Longhorns 27-24.

Heading into Week 10, the top team in the SEC is … wait for it … Texas A&M! The Aggies fell behind early against No. 8 LSU, trailing 17-7 at the half. The second half was a different story. Aggies head coach Mike Elko decided to go with QB Marcel Reed in the second half and the move paid off. Reed ran for three second-half touchdowns and the Aggies picked off LSU QB Garrett Nussmeier three times to land a 38-23 win. Texas A&M is now 7-1 and 5-0 in the SEC.

There was never any question about No. 1 Illinois in its Big Ten clash with No. 20 Illinois. The Ducks led 35-3 at the half and won 38-9. It was much of the same as No. 15 Alabama trounced No. 21 Missouri, 34-0. The Tigers played with an injured Brady Cook at quarterback before he finally left the game in the second half.

Then, there was the performance of the college football experts at Scores & Stats. Not to be outdone, the S&S pros put up 18 picks last week. They were correct on 14 of them, including a very nice two-team parlay that featured North Texas hitting their team total and the Arkansas Razorbacks beating Mississippi State 58-25 as 6.5-point favorites.

Expect more of the same great performances on the field and at the ticket window in Week 10. There are only two matchups of ranked opponents, but both will have an impact on conference championships and the College Football Playoff. No. 3 Penn State hosts No.4 Ohio State in the premier game of the week. No. 18 Pitt travels to No. 20 SMU for an ACC clash that has conference title implications.

Scores & Stats has all the best previews, predictions, and picks for you in Week 10 of the college football season. Keep coming back as our experts will take you through the entire season, all the way to the 2024 College Football Playoff national championship.

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College Football Week 10 Odds

Keep an eye on the latest College Football Odds and monitor how the lines change throughout the week.

As mentioned, we have two games this weekend that feature ranked opponents. The Big Ten matchup between No. 3 Penn State and No. 4 Ohio State is the marquee game of the day. It’s a noon kickoff in Happy Valley. The Buckeyes have won the last seven straight in the series. More on it later. Check out our preview of the game later in this article.

Once again, Week 10 begins with Conference USA and Sun Belt action on Tuesday night. Then, it’s two more C-USA games on Wednesday before a lone American Athletic Conference game featuring Tulane @ Charlotte on Thursday. On Friday night, No. 15 Boise State will host San Diego State in its second consecutive Friday night game.

The Broncos, who beat UNLV last Friday night, are favored by 23.5 against the Aztecs. It’s one of the biggest point spreads of the week. It’s not the biggest though. That honor falls to Western Kentucky, which is favored by 24 points over Kennesaw State. The Owls got their first FBS win in a huge upset over Liberty last week.

A Big 12 showdown has the Week 10’s highest total. TCU will play at Baylor with a current game total listed at 64.5. The Jacksonville State-Liberty game on Wednesday night currently has a total of 63.5. Both Baylor and TCU average over 30 points per game on offense. On defense, Baylor gives up 29.1 (85th) and TCU allows 32.3 (105th).

At the other end, the annual Army-Air Force clash in the Commander-in-Chief Trophy race has the total currently listed at 41.5. The last seven games in this series have not surpassed 35 points. Army won 21-14 in 2021 and that game needed overtime to get to 35. And, that’s not the week’s lowest total. That would UCLA-Nebraska which is currently at 40.5.

College Football Week 10 Schedule

With over 65 College Football games scheduled for Week 10, the following is a list of the featured games of the week:

College Football Week 10 Predictions

Let’s take a look at the featured College Football Week 10 games and make our spread, total, and moneyline NCAAF picks for each game.

Ohio State Buckeyes vs. Penn State Nittany Lions Odds

All eyes will be on this Big Ten showdown on Saturday. It’s No. 4 against No. 3 and No. 4, the road team, is the favorite. That would be Ohio State, which has beaten the Nittany Lions seven times in a row. Penn State’s last win in the series came in 2016. That game was also in State College at Beaver Stadium.

The Buckeyes have also won 11 of the last 12 against Penn State and they are 7-1 SU in their last eight in Happy Valley. What’s interesting is that Ohio State is just 3-4 ATS this season (3-6 ATS in their last nine games overall. Against Penn State, the Buckeyes have covered just twice in the last eight games. They have faced some hefty spreads though, including 48.5 against Akron and 39.5 against Marshall.

Penn State is 7-0 and coming off a strong 28-13 win over Wisconsin. Like Ohio State, the Nittany Lions have struggled against the number. They are 2-4 ATS in their last six games. Penn State has also faced some pretty large point spreads. The Nittany Lions were favored by 34 against Bowling Green, 19.5 against Illinois, and 29.5 against UCLA. PSU failed to cover in each of those three.

Totals bettors should take a look at the history of this game. Last year, both teams were in the top 5 in total and scoring defense. Ohio State won 20-12 and the game total went Under. The Under has cashed in six of the last nine in this series. Both teams are very good defensively again and both are trending Under. Four of the last five for Penn State and 13 of the last 20 for the Buckeyes have all gone Under the game total.

Ohio State Buckeyes vs. Penn State Nittany Lions Predictions

This one will kick off your Saturday. No. 3 against No. 4. Penn State has not had success against Ohio State. The Nittany Lions are 35-9 SU at home since 2018. One-third of those losses have come to the Buckeyes. Ohio State has won 18 of the last 22, dating back to 2002, against PSU.

Ohio State actually doesn’t fare well in this spot either. In their last 21 games against Top 10 teams, the Buckeyes are 6-14-1 ATS and just 2-8 ATS in the last 10. That is the second-worst number among FBS teams since 2018. Only Michigan State (3-13 ATS) is worse.

The big question will be Penn State QB Drew Allar. He left last week’s game and was replaced by Beau Pribula. He is not the passer Allar is, although Pribula is a much better running threat. If Penn State is going to stay in this game, it will be because of its defense. Penn State ranks seventh in scoring defense. Ohio State is second.

This will be Penn State’s third game while ranked in the top 5 facing an opponent with a less than -7 spread. The Nittany Lions are 2-0 SU in that spot. The last four games in this series have seen 41 combined points or less.

Bet: ML Penn State +150, Penn State +3.5 (-110), Under 47.5 (-110)

Duke Blue Devils vs. Miami Hurricanes Odds

Miami continues to roll on. The Hurricanes are 7-0 after their win over Florida State last week. Miami has now won eight straight games and five straight against ACC opponents. Duke is 6-2 and was seconds from being 7-1 until Todd Pelino’s 30-yard field goal was blocked at the end of regulation. Duke would lose 28-27 in overtime.

The Blue Devils beat Miami last year, 45-21, and have won three of the last five meetings. If you go back to 1983, the Blue Devils and Hurricanes have played 19 times. Miami has won 15 times. Miami has won six of the last eight when playing Duke at home. The ‘Canes have covered the spread in just one of the last four games.

Duke has been very good against the number in recent years and it has carried over into this season, the first for Manny Diaz as head coach. The Blue Devils are 5-2-1 ATS this season and they are 21-12-1 ATS (63.6%) since the beginning of the 2022 season. That’s the seventh-best ATS record in that time span.

This game will definitely be a contrast of styles. Diaz and Duke are one of the better defensive teams in the country. They rank in the top 20 in the nation in pass defense and scoring defense. Miami has the top passing offense in college football led by Heisman Trophy contender QB Cam Ward. The Hurricanes average 45.4 points per game, which is the best in the country.

Duke Blue Devils vs. Miami Hurricanes Predictions

The Hurricanes continue to underwhelm. Last week, they let Florida State hang around for a minute. The week before, it was Louisville. Now, the ‘Canes face a very good Duke defense coming off a devastating loss in a game they had won. The Blue Devils had a chip shot 30-yard field goal blocked on the final play of regulation before losing by a point, 28-27, in overtime to SMU.

It’s really a tough spot for Miami. They have been in this spot before as a home favorite and they have not fared well against the number … or against Duke. Since 2018, Miami has been a home favorite 37 times. The Hurricanes are 26-11 SU but just 16-21 ATS. Miami has been a home favorite against Duke twice in that span. The ‘Canes are 0-2 SU and ATS.

While Duke’s defense gets a lot of the credit, QB Maalik Murphy and RB Star Thomas lead a solid Blue Devils offense. If Duke can run the football, they can keep the ball away from Miami’s offense which leads the nation in scoring. The bad taste from the loss last week may give Duke the edge it needs to rise up and pull the upset.

The Over might be in play too. Under head coach Mario Cristobal, Miami is only 5-6 ATS in games after winning the previous game by 20-plus points. The Over is 8-3 in those 11 games.

Bet: ML pass, Duke +20.5 (-110), Over 54.5 (-110)

Air Force Falcons vs. Army Black Knights Odds

It’s Game 2 of the annual Commander-in-Chief Trophy race. It’s the first Saturday in November and that means it’s Air Force at Army. Air Force first played Army in 1959. The CIC Trophy was instituted prior to the 1972 season. Since then, Air Force has dominated this series, going 35-17 SU. All time, the Falcons lead the series 38-19-1 SU.

More recently though, Army has won three of the last four meetings and five of the last seven. The Black Knights are off to a great start this season. They are 7-0 and ranked No. 21 in the country. Army is also the No. 1 team in the American Athletic Conference with a 6-0 conference record. The offense has been outstanding, averaging 356 yards rushing – that leads the nation – and 39.7 points per game (16th).

Air Force has struggled this year. The Falcons are 1-6 SU and they struggle offensively. The Falcons rank 130th in the nation in scoring, averaging just 15.7 points per game. Air Force has also failed to cover the spread in all of its games this season (0-7 ATS). The Falcons are also 0-5 ATS in their last five road games and 0-5 ATS in their last five against Army.

Expect a low-scoring battle. The last seven games in the series have all totaled 35 points or less. Neither team has scored more than 23 points in any of the last seven meetings. The Under has cashed in each of the last 10 Air Force-Army games.

Air Force Falcons vs. Army Predictions

This one is pretty simple. It’s a down year for Air Force. The Falcons are busy rebuilding an offense that was outstanding in 2023. This year … not so much. Air Force is 132nd in the country in scoring (14.3 ppg) and there is no way that they can keep up with Army (40.2 ppg).

The Air Force running game ranks 21st in the nation, but for a team that relies so heavily on the run, that isn’t good enough. It’s definitely not good enough when you’re team ranks dead last in the nation in passing offense (105.5 ypg). The Falcons just don’t sustain drives that lead to points.

Now, these service academy games are typically low-scoring, physical battles. The teams all play similar offenses and, as a result, are pretty good at defending each other. Still, Army is just too good this year. The Black Knights are 7-0 and have an average scoring margin of +26.8. That’s the second-best in the country. Only Ohio State has a higher scoring margin. Army has also hit 40 or more points in each of its last four games.

Bet: ML pass, Army -22.5 (-110), Over 41.5 (-110)

Oregon Ducks vs. Michigan Wolverines Odds

Oregon and Michigan have met just twice since 2003. The Ducks actually won both games and covered in both games. It’s a little different in 2024 compared to the last meeting in 2007. Oregon is now the No. 1 team in the country and they are cruising right along with an 8-0 record. They struggled against the number early, but they are 4-2 ATS in their last six games.

Michigan is 5-3 overall and they have lost two of their last three games. The Wolverines have only covered twice this season (2-6 ATS). They will be home underdogs for the third time this season. This is the first time Michigan will be a home underdog three times in one season since 2009. The only other time that happened was in 1990.

This is Oregon’s first season in the Big Ten and the two teams don’t have much history. But, both programs have been used to winning lately. Michigan is 17-3 SU in its last 20 games overall and the Wolverines are very good at Michigan Stadium. They have won 19 of the last 20 games played there. The only loss was to Texas earlier this season. The Wolverines also have a history of tightening up as the season wears on. They are 9-3 ATS in their last 12 games played in the month of November.

Oregon has experienced great success too, especially under head coach Dan Lanning. Under Lanning, the Ducks are 31-5 SU. They have won their last nine games in a row and their last five road games in a row. The Ducks also have been strong against the number late in a season. They are 8-4 ATS in their last 12 November games.

Oregon Ducks vs. Michigan Wolverines Predictions

As mentioned, this will be the first time since 2009 that Michigan will be a home underdog for thei third time in a season. The Wolverines have only been a double-digit home underdog three times ever. All three games were against Ohio State. Michigan lost all three.

This game will be a clash of styles as the Oregon offense is mighty and multiple. Michigan relies on the running game heavily, but they only average 172.6 yards per game (50th). The passing game ranks 130th in the country. The Michigan defense is solid but not anywhere near what they were last year.

In fact, Oregon’s defense is one of the best in the country. The Ducks are ninth in scoring defense, allowing 15.9 points per game. They are one of four Big Ten teams (Ohio State, Penn State, Indiana) ranked in the Top 10. The big difference will be Oregon’s offense. The Ducks have scored 31-plus points in seven straight games. They have won those seven games by an average margin of 20.7 points.

Lanning is unbeaten as a road favorite (11-0 SU) and his team’s are 9-2 ATS in those 11 games. As a double-digit favorite, Lanning is 23-1 SU and 18-6 ATS. As a double-digit road favorite, he is 8-0 SU and 7-1 ATS. Since 1984, Michigan has played the No. 1 team in the country eight times. They lost all eight. You can guess where this one is headed.

Bet: Oregon -150, Oregon -14.5 (-110), Over 45.5 (-110)

Florida Gators vs. Georgia Bulldogs Odds

It’s time for the world’s Largest Outdoor Cocktail Party, also known as the annual Florida versus Georgia SEC clash. Georgia comes into the game ranked No. 2 in the country. Florida just happens to be playing its best football of the season, but they did lose starting QB Graham Mertz for the season. The Gators won three of their last four with the only loss coming in overtime to seventh-ranked Tennessee.

This rivalry goes back to 1904 or 1915 depending upon which school you believe. The Gators ruled the series during the 1990s under legendary head coach Steve Spurrier. The tide then swung back and forth over the next two decades until the arrival of Kirby Smart at Georgia in 2016. Florida beat the Dawgs that first year, but only have one win since (2020).

Georgia has won each of the last three, all by double-digit margins. They have covered the spread in two of the last three and five of the last seven in the series. It’s interesting that Georgia is just 2-5 ATS this season. They failed to cover in five straight games before the win over Texas two weeks ago.

Florida also had a bye last week. That might not make a difference. The Gators are just 1-5 SU in games after a bye since the beginning of the 2021 season. As mentioned, Florida has won three of its last four and they are 4-0 ATS in those games.

Florida Gators vs. Georgia Bulldogs Predictions

It seemed like everybody was on Texas two weeks ago against Georgia. The Bulldogs answered with a huge 30-15 win. They’ve got the extra week in their pocket too, which has been good to Smart-coached Bulldogs teams. On extended rest, Georgia is 20-3 SU and 15-8 ATS under Smart.

Florida has only closed as a 20-point underdog (or higher) three times: Georgia 2022, Alabama 2016, and Florida State 2013. The Gators lost all three games and went 1-2 ATS. They lost each of those games by at least 21 points. Now, this point spread might not get to 20, but keep in mind Florida has lost 12 straight as a double-digit underdog.

The Georgia defense is still outstanding. The Bulldogs rank in the Top 20 in scoring defense. They’ve held six of their last eight opponents to 15 points or less. Saturday, they will face a Gators offense that will feature a freshman quarterback – D.J. Lagway. The last time Florida faced Georgia with a freshman quarterback, it was 2021. The Gators QB was a guy named Anthony Richardson and Georgia blew out Florida 34-7. Expect more of the same from the world’s biggest cocktail party.

Bet: ML pass, Georgia -16 (-110), Under 52.5 (-110)

Texas A&M Aggies vs. South Carolina Gamecocks Odds

No. 10 Texas A&M travels to Columbia to take on the South Carolina Gamecocks in a Saturday night SEC battle. The Aggies (7-1, 5-0) are the only remaining unbeaten in the SEC. They sit atop the standing with four games to play, three in the conference. The Aggies are in a great position to qualify for the SEC championship game on Saturday, December 7.

South Carolina is 4-3 this season with a pair of losses to LSU and Alabama by a combined five points. The Gamecocks covered in both of those games and they are 5-2 ATS on the season. South Carolina has lost nine of the last ten against Texas A&M, though they did cover the spread in each of the last two meetings.

The Aggies have won seven in a row since their season-opening loss to Notre Dame. Texas A&M has struggled against the number. They are just 3-8 ATS in their last 11 games, including 3-5 ATS this season.

Both teams have been trending Over. Five of the last seven Aggies games and four of the last five Gamecocks games have all exceeded the total. Texas A&M has scored 30 or more points in five of its last seven. South Carolina has scored 25 or more in five of its last six games.

Texas A&M Aggies vs. South Carolina Gamecocks Predictions

This one is interesting. Aggies head coach Mike Elko pulled QB Connor Weigman for Marcel Reed last week. The change saw Reed run for three touchdowns as Texas A&M rallied to beat LSU 38-23. Does Elko go back to Weigman or does he stick with Reed? That situation could be a distraction.

That, plus a few other key points, makes the Aggies ripe for an upset. It was a huge win last week. The emotions of that win took their toll on Texas A&M and now they may look past the Gamecocks. Both Alabama and LSU almost did. A failed two-point conversion against the Tide and a late touchdown by LSU are all that are keeping this from being a matchup of SEC unbeatens.

The Gamecocks defense is legit. They rank 14th in the country in scoring defense, allowing just 18.7 points per game. They rank 15th against the run – Texas A&M’s strong point on offense – and 10th in the nation in total defense. South Carolina is a very opportunistic defense. They do a good job of converting turnovers into points. The Gamecocks have 10 interceptions this season and they are tied for third in the nation with 28 sacks. That defense on its home turf is going to be the difference.

Bet: South Carolina +146, South Carolina +2.5 (-104), Over 44.5 (-110)

Pittsburgh Panthers vs. SMU Mustangs Odds

The Panthers and Mustangs have only met four times in college football history. Four of those meetings took place before the calendar turned to the 1950s. The most recent meeting was in 2012 in the BBVA Compass Bowl. SMU won the game 28-6. Saturday’s matchup will be the first as ACC opponents.

SMU (7-1) is coming off an emotional 28-27 victory over Duke last week. The Mustangs are now 4-0 in conference play and a win moves them closer to their goal of playing for an ACC championship. Clemson (5-0) and Miami (4-0) are also in the mix.

The Mustangs were lucky to get that win last week. SMU committed six turnovers – three interceptions and three fumbles. They also benefited from a missed 30-yard field goal attempt on the final play of regulation. SMU actually blocked the kick and sent the game to overtime. The Mustangs are now 5-0 SU and 4-1 ATS in their last five games. They have won 11 of their last 12 games at home. SMU has played four home games this season and they have won all four by an average margin of 15.7 points.

Pitt is 7-0 SU and 6-1 ATS in their last seven games. The Panthers head coach Pat Narduzzi hired a new offensive coordinator in the offseason. He has made the Panthers play much faster than the past. As a result, Pitt is 19th in the nation in scoring, averaging 35.5 points per game. The Panthers rank right behind SMU in average scoring margin – 12.9 & 12.7. Pitt’s defense had three pick-sixes in last week’s win over Syracuse.

Pittsburgh Panthers vs. SMU Mustangs Predictions

This is a huge conference game for both teams. The loser is likely out of the conference race and probably out of the CFP discussion. That could change if Clemson and/or Miami stumble down the stretch. Pitt is coming off a powerful win that saw the defense come to life. The Panthers defense isn’t as strong as it has been in year’s past under Narduzzi. But, they have held their last two opponents to 13 and 15 points.

SMU’s defense is kind of in the same boat as Pitt’s. The Mustangs are a Top 50 scoring defense and they’ve limited three of their last four opponents to 21 points or less in regulation play. Where this game will be won is on offense. The team that makes the fewest mistakes will likely emerge victorious. As mentioned, SMU committed six turnovers last week. They are also one of the more penalized teams in college football.

The bigger problem for Pittsburgh is the status of QB Eli Holstein. He left the game against Syracuse and he is listed as questionable for Saturday. If the Panthers don’t have their starting quarterback, this one will be tough to pull off. If Holstein isn’t 100 percent, playing on the road with a gimpy quarterback doesn’t induce warm and fuzzies for the Scores & Stats college football staff. It’s also a tough number – 7.5 – to get behind the Mustangs.

Automatically playing the Over is another scary situation. Pitt averages 35.5 points per game; SMU is at 36.3. One would assume that the Over 58.5 is the play; however, as seasons wear on, the Under is actually the better bet. In Week 10 in a 100-plus-game sample, with two teams whose scoring average is more than the set game total, the Under has cashed 56.3 percent of the time.

Bet: ML pass, Pitt +7.5 (-110), Under 58.5 (-110)

Best Bets for College Football Week 10

Our college football experts did a great job last week in correctly predicting last week’s best bets. North Texas went Over its team total and Arkansas was an easy winner over Mississippi State. Once again, our staff has surveyed the schedule and they have come up with these two best bets for Week 10.

• Air Force @ Army Team Total Over 30.5
• Kansas State @ Houston Team Total Under 17.5

Army’s offense is an absolute juggernaut. The Black Knights are averaging 40.2 points per game, which is seventh in the nation. Army has gone Over 30.5 points in all but one of their games this season.

Kansas State is a very good defensive football team. They rank in the Top 50 in most statistical categories. They are strong against the run, which is what head coach Willie Fritz’s Houston team focuses on. Last week against Utah, Houston managed just 17 points. If not for UMass, Houston (133rd) would rank dead last in the nation in scoring. The Cougars average 14.1 points per game.

The Army bet is listed at -150. Houston Under 17.5 points is given -185 odds. Remember, you would need to bet $150 to win $100 on Army and $185 on Houston to win $100. You can also play these two bets as a parlay. Both bets will have to cash, but you can wager $100 at +156 odds, which means your payout will be $256 with a profit of $156.