2024 NFL Week 12 Odds and Predictions

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Rick Rockwell

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It’s hard to believe we’re already to Week 12 of the 2024 NFL season, but here we are. Playoff races are already taking shapes in both conferences. The Kansas City Chiefs will look to bounce back from their first loss of the season with a road date against the Carolina Panthers. A few of the marquee matchups of the week include 49ersPackers, CardinalsSeahawks, and RavensChargers.

As usual, it’s never too early to bet on the action. We’ve already got a full helping of betting odds for every game, so let’s dive on in.

Here’s a full breakdown of Week 12 NFL odds and our betting analysis for each game.

NFL Week 12 Schedule

DateTime (ET)Road TeamHome Team
Thursday, Nov. 218:15 PMPittsburgh SteelersCleveland Browns
Sunday, Nov. 241:00 PMKansas City ChiefsCarolina Panthers
Sunday, Nov. 241:00 PMTampa Bay BuccaneersNew York Giants
Sunday, Nov. 241:00 PMDetroit LionsIndianapolis Colts
Sunday, Nov. 241:00 PMNew England PatriotsMiami Dolphins
Sunday, Nov. 241:00 PMMinnesota VikingsChicago Bears
Sunday, Nov. 241:00 PMTennessee TitansHouston Texans
Sunday, Nov. 241:00 PMDallas CowboysWashington Commanders
Sunday, Nov. 244:05 PMDenver BroncosLas Vegas Raiders
Sunday, Nov. 244:25 PMSan Francisco 49ersGreen Bay Packers
Sunday, Nov. 244:25 PMArizona CardinalsSeattle Seahawks
Sunday, Nov. 248:15 PMPhiladelphia EaglesLos Angeles Rams
Monday, Nov. 258:15 PMBaltimore RavensLos Angeles Chargers

NFL Week 12 Predictions

Let’s dive into the NFL odds for Week 12 and analyze the best NFL picks for the slate of games.

Pittsburgh Steelers vs. Cleveland Browns Odds

TeamMoneylineSpreadTotal
Pittsburgh Steelers-192-3.5 (-112)Over 36 (-112)
Cleveland Browns+160+3.5 (-108)Under 36 (-108)

Fresh off of a stirring win over the AFC North rival Ravens, the Pittsburgh Steelers travel to Cleveland to face another division rival in a highly-anticipated Thursday night showdown. Pittsburgh comes into this matchup as road favorites, leaning on their top-tier defense and efficient run game. Cleveland, meanwhile, is looking for answers amid a lost season.

Jameis Winston had a big game in New Orleans last week, but it wasn’t enough. Winston threw for nearly 400 yards with a couple of touchdowns, but the Browns‘ defense couldn’t stop Taysom Hill, who accounted for well north of 100 scrimmage yards with 3 touchdowns. Cleveland’s defense was a strength coming into the year, but it hasn’t quite lived up to expectations.

Offensively, the Steelers excel at controlling the pace, making it challenging for opponents to capitalize on scoring opportunities. The Browns will need a strong defensive showing to have a chance of pulling off the upset. Russell Wilson improved to 4-0 since taking over for Justin Fields as the Steelers’ QB1 with a solid showing on Sunday. Russ has thrown for 942 yards with 6 touchdowns to 2 interceptions as the starter, though he was held without a TD pass by Baltimore.

While the Browns are the home team in this one, I’m not sure they have enough to slow down this red-hot Pittsburgh outfit. I like the Steelers to win and cover the small 3.5-point margin on the road.

  • The Steelers are 4-1 ATS in their last five road games.
  • The total has gone under in six of the Steelers’ last eight games.
  • The Browns are 3-2 ATS in their last five home games against Pittsburgh.

Pittsburgh Steelers vs. Cleveland Browns Predictions:

  • Spread: Steelers -3.5 (-112) – Pittsburgh’s defense and balanced attack give them a decisive edge.
  • Moneyline: Steelers -192 – With a more consistent offense, Pittsburgh is the safer pick.
  • Total: Under 36 (-108) – Expect a low-scoring, defensive battle between these AFC North foes.
Prediction: Steelers -3.5, Under 36
Best Bet: Steelers -3.5 (-112)

Kansas City Chiefs vs. Carolina Panthers Odds

TeamMoneylineSpreadTotal
Kansas City Chiefs-650-10.5 (-115)Over 41.5 (-108)
Carolina Panthers+470+10.5 (-105)Under 41.5 (-112)

The Kansas City Chiefs visit the Carolina Panthers in a classic David vs. Goliath showdown. Kansas City enters this matchup as heavy favorites, boasting one of the league’s most potent offenses led by Patrick Mahomes. Meanwhile, the Panthers have struggled to find their footing, leaning heavily on Bryce Young and a defense that has been horrendous throughout the season.

The Chiefs fell to 9-1 with Sunday’s 30-21 loss in Buffalo. It wasn’t the most surprising setback considering Kansas City barely managed to beat Denver a couple of weeks ago, but they’re still in the driver’s seat when it comes to AFC playoff seeding. Mahomes threw 3 touchdown passes against the Bills, but he also threw a couple of interceptions. The former MVP now has 11 INTs on the year, and he’s on pace to shatter his previous career-high in that department (14). This week, though, he should have little issue dismantling a Carolina defense that’s been giving it up all year.

The question is whether Kansas City can cover the 10.5-point spread as the road team. The Chiefs may be 9-1 overall, but they’re only 5-5 against the spread. The Panthers have been even worse, however, with a grim 3-7 ATS mark alongside their identical win-loss record.

It won’t be pretty, but I don’t think the Carolina offense is up to the task of putting points on the board against a Chiefs defense that has been among the most stingy in football all year. Give me KC to cover.

  • The Chiefs are 5-2 ATS in their last seven games as road favorites.
  • The total has gone over in four of the Chiefs’ last six games.
  • The Panthers are 2-4 ATS in their last six home games.

Kansas City Chiefs vs. Carolina Panthers Predictions:

  • Spread: Chiefs -10.5 (-115) – Kansas City’s explosive offense is too much for Carolina to handle.
  • Moneyline: Chiefs -650 – The Chiefs are the safe moneyline bet in this lopsided matchup.
  • Total: Over 41.5 (-108) – Expect Kansas City to score enough to push the total over.
Prediction: Chiefs -10.5, Over 41.5
Best Bet: Chiefs -10.5 (-115)

Tampa Bay Buccaneers vs. New York Giants Odds

TeamMoneylineSpreadTotal
Tampa Bay Buccaneers-245-5 (-112)Over 42 (-110)
New York Giants+200+5 (-108)Under 42 (-110)

In this NFC clash, the Tampa Bay Buccaneers travel to face the New York Giants in what promises to be a physical game. The Bucs are battling injuries, while the Giants are battling their own terrible roster. At long last, head coach Brian Daboll has pulled the plug on the Daniel Jones experiment. The Giants’ $160 million quarterback will officially hit the bench for this one, which means Tommy DeVito is in line to start at QB.

We saw plenty of DeVito last season after Jones tore his ACL. The 26-year-old completed 64 percent of his throws for 1,101 yards and 8 touchdowns to 3 interceptions across 9 appearances for Big Blue last year. DeVito added another 195 yards and a rushing touchdown, so he does have some scrambling ability.

We’ll see if DeVito can rejuvenate Malik Nabers, whose rookie year has stalled a bit after a promising start. Nabers has 61 catches for 607 yards through 8 games, but he’s struggled to find his footing since returning from a concussion that sidelined him for a couple of weeks. Jones’ shaky play has plenty to do with that, of course. Nabers still has at least 10 targets in each of the last 3 games, but he hasn’t scored a touchdown since Week 3.

Mike Evans returned to practice for the Bucs this week, so he appears likely to return after missing several games with a hamstring injury. His presence was sorely missed, especially with Chris Godwin already out for the season with an injury of his own. Evans has 6 touchdowns through 7 games on the year, and he figures to see an even larger target share now that he won’t have Godwin stealing some of his looks.

This is a tricky game considering the Giants could be motivated to show out now that Jones has finally been benched. That said, I do think Baker Mayfield will ultimately produce enough offense to get Tampa Bay across the finish line.

  • The Buccaneers are 6-1 ATS in their last seven games against the Giants.
  • The total has gone under in four of Tampa Bay’s last six games.
  • The Giants are 1-4 SU in their last five home games.

Tampa Bay Buccaneers vs. New York Giants Predictions:

  • Spread: Buccaneers -5 (-112) – Tampa Bay’s defense should control this game from start to finish.
  • Moneyline: Buccaneers -245 – The Bucs are the better team on both sides of the ball.
  • Total: Under 42 (-110) – Expect a slower-paced game that keeps the total under.
Prediction: Buccaneers -5, Under 42
Best Bet: Buccaneers -5 (-112)

Detroit Lions vs. Indianapolis Colts Odds

TeamMoneylineSpreadTotal
Detroit Lions-425-7.5 (-105)Over 50.5 (-110)
Indianapolis Colts+330+7.5 (-115)Under 50.5 (-110)

The Detroit Lions travel to Indianapolis to face the Colts as heavy favorites, riding high on their explosive offense led by Jared Goff. This will be Detroit’s 3rd straight game against an AFC South foe after picking up wins over the Houston Texans and Tenessee Titans. The Lions put an NFL-high 52 points on the board last week against the Titans, and something tells me the Colts’ struggling defense won’t be able to keep up in this one.

Detroit is now 9-1 on the year, with their lone loss coming against Tampa Bay at home way back in Week 2. They’ve been a bit more prolific at home than on the road, but there’s no slowing down this offense. Even without Sam LaPorta last week, Goff and co. had no trouble whatsoever getting whatever they wanted. Goff threw for over 400 yards with 4 touchdowns, while David Montgomery and Jahmyr Gibbs combined for 3 rushing scores.

The Colts do have a little momentum, though. Anthony Richardson returned to the lineup following his benching to lead an impressive road win over the New York Jets in Week 11. Richardson’s accuracy has been much maligned since he entered the league, but he was outstanding on Sunday. The Florida product completed 20 of his 30 pass attempts for 272 yards and a touchdown. He added another 32 yards on the ground with 2 rushing TDs, as well.

This has the potential to be a high-scoring affair, as evidenced by the 50.5-point over/under. Considering the Lions have crossed the 50-point threshold by themselves on multiple occasions this year, it’s hard not to favor the over. The Colts have a prolific enough offense to do some damage against this Detroit defense, too.

The Lions’ depth on both sides of the ball makes them the stronger pick, though the Colts have shown resilience in keeping games closer than expected.

  • The Lions are 6-2 ATS in their last eight games.
  • The total has gone under in six of the Colts’ last eight home games.
  • The Colts are 1-5 ATS in their last six matchups against NFC teams.

Detroit Lions vs. Indianapolis Colts Predictions:

  • Spread: Lions -7.5 (-105) – Detroit’s offense should overwhelm the Colts’ defense.
  • Moneyline: Lions -425 – Detroit’s firepower makes them the safe pick straight up.
  • Total: Under 50.5 (-110) – These are a couple of capable offenses, and indoor games are generally more favorable for offense.
Prediction: Lions -7.5, Over 50.5
Best Bet: Over 50.5 (-110)

New England Patriots vs. Miami Dolphins Odds

TeamMoneylineSpreadTotal
New England Patriots+295+7 (-108)Over 46 (-112)
Miami Dolphins-375-7 (-112)Under 46 (-108)

The New England Patriots head to Miami to take on the high-flying Dolphins in an old-school AFC East battle. Miami’s dynamic offense, led by Tua Tagovailoa and Tyreek Hill, poses a significant challenge for New England’s defense. The Patriots are in the midst of a rebuilding season with Drake Maye leading the charge under center.

Miami has posted back-to-back wins to get themselves back into the mix for the AFC playoffs. The Fins picked up a stress-free 34-19 win over the Las Vegas Raiders last week, though they’re still just 4-6 through 10 games. Tua’s return has bolstered the offense, however, and the bottom of the AFC playoff picture is weak enough to where Miami isn’t dead just yet.

The Dolphins slogged their way to a 15-10 win the last time these teams met a few weeks ago in Foxborough, though Tagovailoa was out with a concussion that week. Tyler Huntley got the start, and Miami’s lone offensive touchdown came via an unlikely source, Alec Ingold. Something tells me the Dolphins will have a more fruitful week offensively in the rematch with a full complement of healthy offensive pieces in the fold.

The Pats are just 3-8 so far, but that may be 3 more wins than many expected they’d have by now. Maye has shown promise since taking over for Jacoby Brissett, but the Patriots haven’t done a great job of surrounding their franchise QB with a ton of quality weaponry. They have been competitive, though, and last week’s 28-22 loss to the Los Angeles Rams was surprisingly competitive.

Miami’s explosive playmakers should prove too much for New England to handle, especially if the Dolphins get off to a quick start.

  • The Dolphins are 7-1 ATS in their last eight home games.
  • The Patriots are 1-4 SU in their last five road games.
  • The total has gone over in five of Miami’s last six games.

New England Patriots vs. Miami Dolphins Predictions:

  • Spread: Dolphins -7 (-112) – Miami’s offense should cruise past New England.
  • Moneyline: Dolphins -375 – Miami’s home dominance makes them the clear favorite.
  • Total: Over 46 (-112) – Miami’s offense could drive the total over on its own.
Prediction: Dolphins -7, Over 46
Best Bet: Dolphins -7 (-112)

Minnesota Vikings vs. Chicago Bears Odds

TeamMoneylineSpreadTotal
Minnesota Vikings-166-3.5 (-102)Over 39.5 (-110)
Chicago Bears+140+3.5 (-118)Under 39.5 (-110)

This NFC North clash features the Minnesota Vikings taking on the Bears in Chicago. Minnesota comes in with a slight edge with Chicago’s well-documented recent struggles. The Bears will look to capitalize on their home-field advantage, but their inconsistent offense could hold them back.

Chicago did put points on the board last week, but their dreams were dashed when what would’ve been a game-winning Cairo Santos field goal was blocked in heartbreaking fashion. The Bears have now dropped 4 straight games following a promising 4-2 start, and they’re destined to pull up the rear in the loaded NFC North.

We’ll see if Caleb Williams can get things going. So far, the rookie’s season has been far from memorable. The former Heisman Trophy winner has completed less than 62 percent of his throws for 2,016 yards with 9 touchdowns to 5 interceptions through 10 games. However, he’s in the midst of quite a drought. Williams hasn’t thrown a touchdown pass in any of the last 4 games since his 4-TD showing in London against the Jacksonville Jaguars a month ago.

The Vikings are 8-2, which is a start few saw coming entering the campaign. Minnesota has won 3 straight on the heels of a 2-game skid, with wins over the Colts, Jaguars, and Titans. This will be the Vikings’ first of 2 showdowns against the Bears in the next 4 games. While they’re only a game adrift of Detroit in the division standings, few still consider the Vikings to be a serious threat coming out of the NFC.

I don’t hate a flier on the Bears in this spot. Minnesota likely isn’t as good as their record indicates, and Chicago came close to an upset win over Green Bay in Week 11. This is the week the Bears finally get off the mat and back into the win column.

  • The Vikings are 5-0 SU in their last five games against the Bears.
  • The Bears are 2-6 ATS in their last eight home games.
  • The total has gone under in four of the Bears’ last five games.

Minnesota Vikings vs. Chicago Bears Predictions:

  • Spread: Bears +3.5 (-118) – The Vikings are the better team, but I don’t buy them as a team who should have an .800 win percentage.
  • Moneyline: Bears +140 – Chicago’s +140 moneyline odds offer profit potential.
  • Total: Under 39.5 (-110) – Both defenses could dominate in a low-scoring affair.
Prediction: Bears +3.5, Under 39.5
Best Bet: Bears ML (+140)

Tennessee Titans vs. Houston Texans Odds

TeamMoneylineSpreadTotal
Tennessee Titans+320+8 (-110)Over 42 (-110)
Houston Texans-410-8 (-110)Under 42 (-110)

The Houston Texans host the Tennessee Titans in an AFC South battle. The Texans snapped a 2-game losing streak with a 34-10 win over the hapless Dallas Cowboys on Monday Night Football. The Titans, on the other hand, are off to a grim 2-8 start with 2 straight losses coming into this one. Tennessee’s lone victories of the season have come expense of the Dolphins (without Tua Tagovailoa) and Patriots.

Houston got Nico Collins back into the lineup in Week 11, but Joe Mixon is the heart and soul of Houston’s offense this year. The first-year Texan is having the best season of his career. He added another 150 total yards and 3 touchdowns to his ledger against Dallas, bringing his TD total for the year to 11. What makes that all the more impressive is that Mixon missed 3 games earlier in the year with a sprained ankle.

The Titans’ defense isn’t awful, but this is a good get-right spot for the Texans’ passing game. CJ Stroud hasn’t been quite as prolific as he was as a rookie last season, but the injuries to Collins and Stefon Diggs have played a role. Collins was quiet in his return to the lineup, though he did have a 75-yard touchdown reception nullified by a penalty on the first play of the game.

Will Levis sure doesn’t look like the long-term answer in Tennessee. For the season, the 2nd-year QB has as many interceptions as touchdown passes (8), and he’s only averaging 6.5 yards per throw. Tennessee was getting decent production from the rushing tandem of Tony Pollard and Tyjae Spears earlier in the year, but Pollard’s output has slowed considerably over the past couple of weeks.

This game could come down to Houston’s ability to finish drives in the red zone, while Tennessee needs their defense to make timely stops to stay competitive.

  • The Titans are 1-5 ATS in their last six road games.
  • The Texans are 5-1 ATS in their last six home games.
  • The total has gone under in five of the Titans’ last seven games.

Tennessee Titans vs. Houston Texans Predictions:

  • Spread: Texans -8 (-110) – Houston’s offense should outpace the Titans by a wide margin.
  • Moneyline: Texans -410 – The Titans simply can’t keep up.
  • Total: Under 42 (-110) – Both teams’ reliance on the run game may keep scoring low.
Prediction: Texans -8, Under 42
Best Bet: Texans -8 (-110)

Dallas Cowboys vs. Washington Commanders Odds

TeamMoneylineSpreadTotal
Dallas Cowboys+425+10.5 (-112)Over 45.5 (-110)
Washington Commanders-575-10.5 (-108)Under 45.5 (-110)

The Washington Commanders welcome the Dallas Cowboys for an NFC East rivalry showdown. The Cowboys’ season has unraveled in a hurry, while the Commanders are still very much in the thick of the divisional race. Last week’s loss to the Philadelphia Eagles means Washington may ultimately have to settle for a Wild Card berth, but that’s hardly a bad consolation prize considering few expected much of the Commanders this season.

Jayden Daniels got off to a blazing start, but the rookie has had a tougher time getting it going in recent weeks. I do think he’s the real deal, but it’s been a while since the Commanders have let him try to do damage on the ground. Daniels did deal with a rib injury earlier in the campaign, but he still hasn’t attempted at least 10 rushing attempts in a game since October 6th. Daniels’ slight frame makes him an injury risk, but his ability to affect games on the ground is what truly unlocks this offense.

For the Cowboys, the end of the season can’t come soon enough. Cooper Rush and the offense did look a little better last week against Houston than they did 2 weeks ago against Philadelphia, but the lack of a running game is a death knell. Rico Dowdle and co. couldn’t generate much of anything on the ground against the Texans, so Rush had to attempt 55 throws in a surprisingly pass-heavy game script. Needless to say, having Rush throw the ball 40-60 times is not a recipe for success for Dallas.

I don’t think the Commanders are a contender just yet, but they are a whole hell of a lot better than this iteration of the Cowboys. Washington’s strength as a run-heavy offense plays right into the Cowboys’ weakness, the run defense.

  • The Cowboys are 2-4 ATS in their last six road games.
  • Washington is 4-2 ATS in their last six games as home favorites.
  • The total has gone over in five of the Cowboys’ last seven games.

Dallas Cowboys vs. Washington Commanders Predictions:

  • Spread: Commanders -10.5 (-108) – Washington should run the ball down Dallas’ throats in this one.
  • Moneyline: Commanders -575 – Washington’s consistency at home gives them the edge.
  • Total: Over 45.5 (-110) – Dallas’ offense may generate enough to push the total over.
Prediction: Commanders -10.5, Under 45.5
Best Bet: Commanders -10.5 (-108)

Denver Broncos vs. Las Vegas Raiders Odds

TeamMoneylineSpreadTotal
Denver Broncos-238-5.5 (-108)Over 41 (-110)
Las Vegas Raiders+195+5.5 (-112)Under 41 (-110)

The Denver Broncos head to Las Vegas to face their AFC West rival Raiders in a game that could have significant divisional implications. Denver’s defense has been a strong point, while the offense has been a pleasant surprise of late under rookie QB Bo Nix. The Raiders…uh…are still playing football games.

Denver is 6-5 after last week’s impressive 38-6 demolition of the Atlanta Falcons. Nix threw a career-high 4 touchdown passes, and he’s come on strong after a so-so start to his first NFL season. Nix only threw 5 incomplete passes while throwing for over 300 yards, as well. Denver also got a solid showing on the ground from Javonte Williams, who found the end zone and added 59 yards rushing on just 9 attempts.

Against the Raiders’ lackluster defense, I’d be surprised if the Broncos’ offense didn’t keep chugging along in this one. Expect a healthy contingent of Denver fans to make the trek west into Nevada for this one. I wouldn’t expect the Denver defense to have much trouble with Gardner Minshew and a Raiders offense that hasn’t generated much consistency this season. The offseason departure of Josh Jacobs and the midseason trade of Davante Adams has left Vegas with a shortage of playmakers on offense.

One bright spot is rookie tight end Brock Bowers, however. The former Georgia standout has been everything the Raiders could’ve hoped for when they took him with their first-round pick in April. set new career-highs in catches (13), targets (16), and receiving yards (126) last week against Miami while adding a receiving touchdown for good measure. For the year, Bowers has 70 catches for 706 yards and 3 scores.

While the spread may indicate oddsmakers aren’t ready to fully buy into what the Broncos have done offensively in recent games, I think they’re underrating Denver. I love the value on the Broncos to win and cover the 5.5-point spread easily, even on the road.

  • The Broncos are 4-2 ATS in their last six games.
  • The Raiders are 2-5 ATS in their last seven home games.
  • The total has gone under in five of the last six matchups between these two teams.

Denver Broncos vs. Las Vegas Raiders Predictions:

  • Spread: Broncos -5.5 (-108) – Denver’s defense should stifle the Raiders.
  • Moneyline: Broncos -238 – Denver has the edge with their resurgent offense.
  • Total: Under 41 (-110) – Expect a defensive battle with limited scoring.
Prediction: Broncos -5.5, Under 41
Best Bet: Broncos -5.5 (-108)

San Francisco 49ers vs. Green Bay Packers Odds

TeamMoneylineSpreadTotal
San Francisco 49ers+114+2.5 (-110)Over 48 (-110)
Green Bay Packers-135-2.5 (-110)Under 48 (-110)

The Packers host the 49ers in a marquee NFC matchup. Green Bay’s balanced offense, led by Jordan Love, has been efficient in recent weeks. San Francisco, meanwhile, has surprisingly struggled on the heels of last year’s NFC championship. The Niners’ dramatic loss last week to Seattle dropped them to just 5-5 on the season. Despite a division-leading plus-28 point differential, the 49ers are technically sitting in the bottom of the division as of now.

Christian McCaffrey carried the ball 19 times for 79 yards in a fairly inefficient effort. The Niners missed George Kittle in this one, as Brock Purdy struggled mightily through the air. Purdy completed 21 of his 28 attempts for just 159 yards. Other than Jauan Jennings – who totaled 10 catches for 91 yards and a score – nobody on the San Francisco side was heavily involved in the passing attack. Deebo Samuel gained just 21 total yards from scrimmage only 5 touches.

While the Lions and Vikings are jockeying atop the NFC North, let’s not overlook the Packers, who improved to 7-3 with last week’s last-second win in Chicago. Green Bay also enters this game as winners of 5 of their last 6, with the lone setback being a home loss to Detroit a couple of weeks ago.

Josh Jacobs hasn’t generated many headlines this season, but he’s been a stellar replacement for the departed Aaron Jones. Jacobs is averaging a shade south of 5 yards per carry, and he found the end zone for the 4th time this season back in Week 11.

The Packers are favored at home in this one, as they’ll seek revenge after their playoff elimination at the hands of the Niners last year. We don’t often get to bet on the 49ers as underdogs, though, and I refuse to believe they’re as poor as their 5-5 record indicates. I think they’ll jump at the opportunity to make a statement in this one on the road.

  • The 49ers are 5-1 ATS in their last six road games.
  • The Packers are 3-2 ATS in their last five games at home.
  • The total has gone over in four of the last six games between these teams.

San Francisco 49ers vs. Green Bay Packers Predictions:

  • Spread: 49ers +2.5 (-110) – San Francisco’s defense could make the difference late.
  • Moneyline: 49ers +114 – San Francisco is worth the upset pick.
  • Total: Over 48 (-110) – Both offenses should have plenty of opportunities to score.
Prediction: 49ers +2.5, Over 48
Best Bet: 49ers +2.5 (-110)

Arizona Cardinals vs. Seattle Seahawks Odds

TeamMoneylineSpreadTotal
Arizona Cardinals+108+1 (-115)Over 47.5 (-108)
Seattle Seahawks-112-1 (-105)Under 47.5 (-112)

The Seattle Seahawks host the Arizona Cardinals in what’s expected to be a tightly contested NFC West matchup. Seattle enters as slight favorites, driven by their efficient offense led by Geno Smith and a solid defense. Arizona, on the other hand, has leaned heavily on Kyler Murray’s dual-threat abilities since his return from injury.

The weather could be a factor in this one. The Pacific Northwest is getting smacked by a bomb cyclone, which is bringing wet weather to the area all weekend long. Seattle is no stranger to soggy conditions, of course, but persistent rain could certainly affect the way these 2 teams approach things offensively.

The Seahawks picked up an impressive win over the 49ers last week, while the Cardinals are coming off of their bye. Arizona has been surprisingly plucky this season, but 4 of their 6 wins have come at home. The Cardinals come into this one riding a 4-game winning streak, but this isn’t a team used to playing in shaky weather.

The outcome could legitimately go either way, but I have my eye on the over/under. The 47.5-point total wouldn’t be too high in standard conditions, but I’m skeptical either team will be able to mount that much offense if the weather isn’t cooperating.

  • The Cardinals are 4-1 ATS in their last five road games.
  • The Seahawks are 2-5 ATS in their last seven games against NFC opponents.
  • The total has gone under in five of Seattle’s last seven games.

Arizona Cardinals vs. Seattle Seahawks Predictions:

  • Spread: Seahawks -1 (-105) – Seattle’s home-field advantage gives them the edge.
  • Moneyline: Seahawks -112 – The Seahawks are a safer pick in this close matchup.
  • Total: Under 47.5 (-112) – The offenses are capable, but Mother Nature may have the last laugh.
Prediction: Seahawks -1, Under 47.5
Best Bet: Under 47.5 (-112)

Philadelphia Eagles vs. Los Angeles Rams Odds

TeamMoneylineSpreadTotal
Philadelphia Eagles-166-3 (-110)Over 50.5 (-112)
Los Angeles Rams+140+3 (-110)Under 50.5 (-108)

The Philadelphia Eagles travel to Los Angeles for a primetime NFC showdown against the Rams. The Eagles picked up an impressive win over Washington in Week 11 thanks to another outstanding effort from Saquon Barkley. The Rams, meanwhile, flew across the country and escaped Foxborough with a 28-22 win over the surprisingly competitive Patriots.

The Birds went all-in with their decision to pay Barkley as a free agent, and it’s paid dividends early on. The former Giant has been outstanding, as he’s rushed for 1,137 yards on just 197 attempts through his first 10 games in Philly. That’s an average of 5.8 yards per carry, as his explosiveness has been on display on a weekly basis. Barkley has also scored 10 total touchdowns, including a pair of rushing scores in last week’s win over the Commanders.

The Rams’ aerial attack was on display on Sunday in New England. Matthew Stafford completed 18 of his 27 throws for 295 yards with 4 touchdowns and no interceptions in a dominant effort. Puka Nacua and Cooper Kupp combined for 13 catches and 3 touchdowns with both players topping 100 yards receiving.

We can always expect a condensed target share for the Rams with a couple of Pro Bowl receivers on the roster, though don’t be surprised if Los Angeles looks to get Kyren Williams going. After scoring at least one touchdown in each of the season’s first 7 games, Williams has failed to find paydirt in any of LA’s last 3 outings.

I get why Philly is favored here, but I don’t mind a flier on the Rams as a home underdog. If the offense gets cooking, the Eagles’ defense is going to have trouble keeping them under wraps on the road.

  • The Eagles are 6-1 ATS in their last seven road games.
  • The Rams are 3-4 ATS in their last seven home games.
  • The total has gone over in four of the Eagles’ last six games.

Philadelphia Eagles vs. Los Angeles Rams Predictions:

  • Spread: Rams +3 (-110) – The Rams have been inconsistent, but the offense looked electric last week.
  • Moneyline: Rams +140 – LA is a solid value as a home underdog.
  • Total: Over 50.5 (-112) – Both offenses have the firepower to hit the over.
Prediction: Rams +3, Over 50.5
Best Bet: Rams ML (+140)

Baltimore Ravens vs. Los Angeles Chargers Odds

TeamMoneylineSpreadTotal
Baltimore Ravens-148-3 (+100)Over 51 (-110)
Los Angeles Chargers+124+3 (-120)Under 51 (-110)

Week 12 concludes with an exciting Monday Night Football matchup as the Baltimore Ravens visit the Los Angeles Chargers. Baltimore’s Lamar Jackson has been in MVP form, though the offense sputtered in last week’s loss in Pittsburgh. The Chargers, meanwhile, have rattled off 4 consecutive victories to get themselves back into the AFC playoff mix.

Jackson has amazing numbers, with 25 touchdown passes to just 3 interceptions thus far. He’s already surpassed his TD pass total from last season when he won MVP for the second time in his career. He was held below 50 percent completions last week by the Steelers, however, and this week’s matchup against the Bolts isn’t much easier. The Chargers’ defense has been outstanding this season under Jim Harbaugh.

The Chargers got off to a so-so start, but the offense has started to click in recent weeks. Justin Herbert has now thrown 13 touchdowns to just 1 interception on the year, while he’s tossed at least a couple of touchdown passes in 3 of the last 4 games. Herbert was also the Bolts’ leading rusher last week against the Bengals, totaling 65 yards on just 5 rushing attempts. Herbert should find some success here against a Ravens defense that has fallen off a cliff since losing defensive coordinator Mike Macdonald to the Seahawks this offseason.

While the Chargers are a team on the rise, I think the Ravens will be hungry to make a statement after a disheartening loss to Pittsburgh last week. I like Baltimore to win and cover here on the road.

  • The Ravens are 4-1 ATS in their last five road games.
  • The Chargers are 2-3 ATS in their last five home games.
  • The total has gone under in four of the Ravens’ last six games.

Baltimore Ravens vs. Los Angeles Chargers Predictions:

  • Spread: Ravens -3 (+100) – Baltimore’s defense and rushing attack should secure the win.
  • Moneyline: Ravens -148 – Lamar Jackson’s consistency makes Baltimore the better pick.
  • Total: Under 51 (-110) – Expect a lower-scoring game with two solid defenses on display.
Prediction: Ravens -3, Under 51
Best Bet: Ravens -3 (+100)

NFL Week 12 Best Bets

After analyzing the Week 12 matchups, here are my favorite betting picks:

  • Baltimore Ravens -3 (+100)
  • San Francisco 49ers +2.5 (-110)
  • Washington Commanders -10.5 (-108)

Each of these bets offers value as standalone wagers, but combining them into a parlay can create the opportunity for a much larger payout. A $100 parlay on these three bets would return approximately $644 if they all hit. You can choose to bet on these individually or go for the higher payout with a Week 12 parlay.