2024 NFL Week 16 Odds and Predictions

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We’ve reached the final three weeks of the 2024 regular season, and Week 16 is here. The schedule takes a bit of a twist this week, giving us plenty of football to enjoy across multiple days. Things get rolling with an AFC West rivalry clash between the Chargers and Broncos on Thursday Night Football. Then, Saturday serves up a stellar two-game slate featuring four AFC teams with Super Bowl aspirations.

Sunday brings us a full lineup of games to feast on, and we’ll close things out with a more low-key Monday Night Football matchup to wrap up the week. Buckle up—this is where the playoff races really start to heat up. Before you know it, Super Bowl 59 will be here, and with just a few weeks of regular season action left, our betting opportunities are running out. Let’s make the most of them while we still can.

Below, you’ll find my favorite ways to bet on the NFL odds for every game on the Week 16 schedule.

NFL Week 16 Schedule 

NFL Week 16 Predictions

Let’s dive right into the NFL analysis and win ourselves some money, shall we?

Denver Broncos vs. Los Angeles Chargers Odds

The Denver Broncos moved one step closer to ending their playoff drought with a crucial win over the Colts last week. The Los Angeles Chargers, on the other hand, suffered a blowout loss at home to the Buccaneers. While both teams are technically still chasing Kansas City in the AFC West, the real battle here is for a wild card spot in the AFC playoff race.

Heading into Thursday night’s showdown, Denver holds a one-game edge over Los Angeles in the standings, making this matchup a massive one with postseason implications on the line.

Justin Herbert is battling an ankle injury, but the Chargers’ bigger issue is their inability to run the football without the injured J.K. Dobbins. Last week against Tampa Bay, Gus Edwards and Kimani Vidal managed just 32 yards on 11 carries, leaving the offense completely one-dimensional. To make matters worse, Herbert’s injury limited him to zero rushing attempts, taking away a key part of his game.

That puts even more pressure on Herbert to carry the offense through the air, but he’s in for a tough challenge against a Broncos defense that has been one of the league’s best this season. Denver’s ability to pressure the quarterback and limit big plays could make it a long night for the Chargers.

The matchup won’t be any easier for Bo Nix, though he did play well the last time these teams met back in October. That said, I expect this game to be a defense-first, lower-scoring affair. Both defenses have been solid, and the short week of rest on Thursday night doesn’t do either offense any favors.

Betting the under feels like the best way to approach this one, as points could be tough to come by in what should be a physical, tightly contested game.

Betting Trends:

• The Broncos are 5-2 ATS in their last 7 games as road underdogs.
• The Chargers are 4-1 ATS in their last 5 home games.
• The total has gone under in 6 of Denver’s last 8 games.

Predictions:

• Spread: Chargers -3 (-108) – Los Angeles’ home-field edge and better offensive weapons should give them the advantage.
• Moneyline: Chargers (-155) – A solid pick at home with their season on the line.
• Total: Under 42 (-110) – Both defenses are solid, and this game could turn into a grind-it-out affair.

Final Score Prediction: Chargers 20, Broncos 16
Best Bet: Under 42 (-110)

Houston Texans vs. Kansas City Chiefs Odds

We’ll see if Patrick Mahomes can suit up for the Kansas City Chiefs this week after spraining his ankle late in last week’s win over the Browns. If Mahomes can’t go, Carson Wentz will get the nod under center for the defending champs. While Wentz brings experience, it’s a clear downgrade for Kansas City’s offense heading into this matchup.

The Houston Texans, meanwhile, clinched both a playoff berth and the AFC South title last week, thanks to their win over Miami and the Colts’ loss in Denver. With Houston now locked into the postseason, they could look to build momentum or take a more cautious approach depending on how they view their seeding opportunities.

Arrowhead Stadium has been a house of horrors for the Texans over the years, but maybe this is the week they finally exorcise some demons. The fact that Houston is favored here suggests that oddsmakers expect Patrick Mahomes to miss this game. With Kansas City already on the verge of locking up the No. 1 seed in the AFC, they can afford to be cautious and give their franchise quarterback time to heal ahead of the playoffs.

For Houston, there’s still plenty at stake. They’re battling it out with Pittsburgh for the potential No. 3 seed in the AFC, so you can expect the Texans to approach this one with a sense of urgency. If Mahomes sits, this is a golden opportunity for Houston to capitalize and make a statement on the road.

It’s not the most comfortable pick, especially given how porous the Texans’ offensive line has been, but I like Houston to get the job done on the road—assuming Carson Wentz starts for Kansas City. The Texans have more to play for at this point, and with Mahomes likely sidelined, the matchup tilts in their favor. Take Houston’s -130 moneyline and trust them to take advantage of the opportunity.

Betting Trends:

• The Chiefs are 7-1 ATS in their last 8 games as home underdogs.
• The Texans are 4-2 ATS in their last 6 road games.
• The total has gone under in 5 of Kansas City’s last 7 games.

Predictions:

• Spread: Texans -2.5 (-108) – Houston’s defense has been strong, and Stroud has shown poise in big games.
• Moneyline: Texans (-130) – Houston takes advantage of KC’s offensive struggles.
• Total: Under 39.5 (-108) – Both defenses should shine in a low-scoring affair.

Final Score Prediction: Texans 21, Chiefs 17
Best Bet: Texans ML (-130)

Pittsburgh Steelers vs. Baltimore Ravens Odds

Pittsburgh Steelers–Baltimore Ravens is as classic as it gets—an old-school AFC North rivalry that renews itself on Saturday evening. The Steelers took the first meeting in a gritty, low-scoring 18-16 affair at home several weeks ago, but this time around, the Ravens are nearly a touchdown favorite.

Baltimore comes into this one riding high after cruising to an easy win over the hapless Giants, while the Steelers are looking to bounce back following a tough loss in Philadelphia. With both teams known for their physicality and defense, expect another hard-fought battle in a game that feels like it always comes down to the final possession.

Josh Allen may be the MVP frontrunner right now, but Lamar Jackson is making a compelling case to challenge him. The reigning MVP put on a show last week against New York, throwing for a staggering five touchdowns. Jackson now has 35 touchdowns to just 3 interceptions on the season, along with over 3,500 passing yards.

Unlike in past seasons, Jackson hasn’t needed to rely as heavily on his legs thanks to the Ravens’ success through the air. That balance has been key, and Derrick Henry’s steady presence in the backfield has given Baltimore the kind of reliable run game they’ve lacked in recent years. With Jackson at the helm and Henry helping to keep defenses honest, Baltimore’s offense is as dangerous as it’s ever been.

We’ll see if the Steelers’ offense can bounce back this week. George Pickens has missed the last two games with a hamstring injury, and his absence has clearly impacted Pittsburgh’s passing attack. Without Pickens stretching the field, the Steelers have struggled to find consistency through the air.

Najee Harris also had a tough outing against Philadelphia, failing to get anything going on the ground. However, the matchup this week looks more favorable on paper, as Baltimore’s defense has struggled at times this season, particularly against the run. If Pickens returns and Harris can take advantage of this softer matchup, Pittsburgh could keep this one interesting.

The 6-point spread feels a bit too large for a matchup between two teams of this caliber, especially given the history of close, hard-fought games in this rivalry. Even with their recent struggles, I like Pittsburgh to cover the spread on the road in what should be another gritty, low-scoring AFC North battle.

Betting Trends:

• The Ravens are 6-1 ATS in their last 7 games at home.
• The Steelers are 5-2 ATS in their last 7 games as underdogs.
• The total has gone under in 4 of the last 5 meetings between these two teams.

Predictions:

• Spread: Steelers +6 (-108) – Baltimore’s defense is porous enough to keep the Steelers in the game.
• Moneyline: Ravens (-285) – A safer pick outright at home.
• Total: Under 44.5 (-108) – Expect a low-scoring, physical AFC North battle.

Final Score Prediction: Ravens 24, Steelers 20
Best Bet: Steelers +6 (-108)

Philadelphia Eagles vs. Washington Commanders Odds

Let’s shift to the NFC East, where the Philadelphia Eagles will take on the Washington Commanders in a matchup with major playoff implications. Philadelphia comes into this one virtually tied with Detroit at 12-2 for the NFC’s top seed, while Washington is holding on to a wild card spot at 9-5 after last week’s heart-stopping win in New Orleans.

The Eagles got the better of the Commanders in their first meeting earlier this season and now look to secure the series sweep on the road. Despite Philadelphia’s dominance this year, they’re only 3.5-point favorites, which feels a bit tight given their form. This sets up as a huge game for both teams with postseason positioning on the line.

The Commanders had no answer for Saquon Barkley in the first meeting between these teams. Barkley gashed Washington for 146 rushing yards and two touchdowns in the Eagles’ 26-18 win at home last month. Stopping Barkley is easier said than done, but there’s at least some blueprint to follow—Pittsburgh managed to hold him to just 65 yards on the ground last week.

If Washington wants to keep this one close, they’ll need to find a way to slow down Barkley and force Jalen Hurts to beat them through the air. That’s a tall task, given how dominant Philadelphia’s run game has been all season.

We’ll see if the Commanders can get their passing game going this week. Terry McLaurin was held in check the last time these teams met, managing just one catch for 10 yards, as no Washington wide receiver caught more than a single pass in that matchup. Surprisingly, the team’s leading receiver in that game was Austin Ekeler, who hauled in a handful of short passes out of the backfield.

However, Washington will likely be without Ekeler this time around, as he’s dealing with a concussion. That puts even more pressure on McLaurin and the rest of the receiving corps to step up against a tough Eagles secondary. If the Commanders can’t get anything going through the air, it could be a long afternoon in D.C.

The spread feels a little too small considering how well the Eagles have played for most of the year. Philadelphia’s balanced offense and dominant run game should allow them to control this one from start to finish. Give me the Eagles to cover on the road and move one step closer to locking up the top seed in the NFC playoffs.

Betting Trends:

• The Eagles are 8-2 ATS in their last 10 games as road favorites.
• The Commanders are 3-6 ATS in their last 9 games.
• The total has gone under in 5 of Washington’s last 7 games.

Predictions:

• Spread: Eagles -3.5 (-105) – Philadelphia’s run game should be too much for Washington to handle.
• Moneyline: Eagles (-170) – A solid road win for the division leaders.
• Total: Under 45.5 (-112) – Washington’s offense struggles to keep pace.

Final Score Prediction: Eagles 27, Commanders 17
Best Bet: Eagles -3.5 (-105)

Cleveland Browns vs. Cincinnati Bengals Odds

The Battle of Ohio features two teams that have fallen well short of expectations this season. After a few weeks on the Jameis Winston rollercoaster, the Cleveland Browns are making another change under center, turning to Dorian Thompson-Robinson as the starter this week in Cincinnati.

The Cincinnati Bengals, meanwhile, struggled more than expected in last week’s win over Tennessee, but they come into this matchup as healthy 7-point favorites at home. With Cleveland seemingly ready to wave the white flag on their season, Cincinnati has a prime opportunity to pick up a convincing win and keep their slim playoff hopes alive.

Cincinnati won the last meeting between these teams 21-14, a game most remembered for Deshaun Watson’s season-ending Achilles injury. Both Dorian Thompson-Robinson and Jameis Winston saw time in relief, with Thompson-Robinson completing just 11 of 24 pass attempts in a forgettable outing.

It’s hard to see why Cleveland is bothering to start him again. Thompson-Robinson has shown next to nothing in his opportunities over the past couple of seasons, yet here they go again with this experiment. Against a Bengals defense that knows how to pressure quarterbacks, it could get ugly quickly.

The Bengals’ defense is bad enough that they could mess around and let the Browns hang around for a bit, but I doubt it. Cleveland’s defense has been a major disappointment this season, and I don’t see them slowing down Ja’Marr Chase or Tee Higgins.

Cincinnati has also gotten a phenomenal year out of Chase Brown, who has quietly been on a tear, scoring at least one touchdown in each of the last three games. With their playmakers clicking and Cleveland rolling out DTR again, the Bengals should roll in this one.

Betting Trends:

• Bengals are 6-1 ATS in their last 7 home games.
• Browns are 2-5 ATS in their last 7 road games.
• The total has gone over in 4 of Cincinnati’s last 5 games.

Predictions:

• Spread: Bengals -7 (-110) – Burrow and the Bengals’ offense should pull away late.
• Moneyline: Bengals (-325) – Cincinnati avoids the upset and keeps playoff hopes alive.
• Total: Over 48 (-108) – Both offenses can score, and this one could be a shootout.

Final Score Prediction: Bengals 38, Browns 10
Best Bet: Bengals -7 (-110)

Los Angeles Rams vs. New York Jets Odds

The Los Angeles Rams will fly 3,000 miles across the country to take on the New York Jets in a battle of veteran quarterbacks. Los Angeles enters this matchup leading the tightly contested NFC West after grinding out a low-scoring win over the 49ers in Santa Clara last week.

The Jets, meanwhile, picked up a much-needed win over the Jaguars behind a monster performance from Davante Adams and a surprisingly effective passing attack. With the Rams still fighting for playoff positioning and the Jets perking up a bit, this cross-country showdown has plenty on the line, even if it might not be the cleanest game we’ll see this week.

Los Angeles is only favored by a little more than a field goal here, which feels a bit light. Teams traveling across the country often struggle with the time zone change, so there’s a chance the Rams’ offense could come out a little sluggish.

The problem for the Jets is their defense—it’s bad. We saw it last week when even Mac Jones and the Jaguars’ offense looked competent, which says a lot. Even if the Rams start a little sleepy, they should have no trouble putting points on the board against this shaky Jets defense.

The Jets have already made it clear they don’t see Aaron Rodgers as part of their future, but the old man has looked a little better of late. Rodgers threw three touchdown passes last week, just a game removed from his first 300-yard performance of the season.

Davante Adams, meanwhile, continues to show he’s got plenty left in the tank. He exploded for 9 catches, 198 yards, and 2 touchdowns against Jacksonville, following up a 109-yard performance the week before. Adams remains a target machine, with at least 11 targets in 5 of the Jets’ last 6 games. Slowing him down will be the top priority for the Los Angeles defense, but that’s easier said than done with Rodgers looking sharper.

The Jets have shown some fight lately, but I’d still be surprised if the Rams let this one slip away. Los Angeles has too much talent on both sides of the ball to stumble here, even with the cross-country travel. It won’t be easy, but I like LA to take care of business and pick up the road win.

Betting Trends:

• Rams are 4-2 ATS in their last 6 games.
• Jets are 1-4 ATS in their last 5 home games.
• The total has gone over in 6 of the Rams’ last 8 games.

Predictions:

• Spread: Rams -3.5 (-108) – LA’s offense is rolling, and the Jets won’t keep up.
• Moneyline: Rams (-180) – Stafford and Nacua should overwhelm New York’s defense.
• Total: Over 46.5 (-110) – The Rams will score enough to push this total over.

Final Score Prediction: Rams 27, Jets 17
Best Bet: Rams -3.5 (-108)

Arizona Cardinals vs. Carolina Panthers Odds

After last week’s win at home over the Patriots, the Arizona Cardinals will head across the country to face the Carolina Panthers in Charlotte. Carolina, favored for the first time in what felt like forever against the Cowboys, predictably fell flat and lost in blowout fashion.

This week, Arizona enters as a 4-point favorite on the road, and it’s easy to see why. The Cardinals have been far more competitive and consistent, while the Panthers continue to struggle in just about every phase of the game. Traveling east is never easy, but this is a spot where Arizona should be able to take care of business.

The Cardinals tend to struggle more on the road, so this one won’t necessarily be a walk in the park. Their best bet is to lean heavily on James Conner, who torched the Patriots for 110 rushing yards and two touchdowns last week.

The Panthers’ run defense has been a disaster all season, and there’s no reason to think they’ll suddenly figure it out here. I expect Conner to have another massive game, paving the way for Arizona to control the clock and keep Carolina’s offense off the field.

Betting Trends:

• Cardinals are 5-2 ATS in their last 7 games as road favorites.
• Panthers are 3-6 ATS in their last 9 home games.
• The total has gone under in 4 of Carolina’s last 6 games.

Predictions:

• Spread: Cardinals -4 (-108) – Arizona’s offense has too much firepower for Carolina.
• Moneyline: Cardinals (-198) – The Cardinals keep their playoff hopes alive.
• Total: Under 47 (-112) – Carolina’s offense won’t contribute enough to hit the over.

Final Score Prediction: Cardinals 26, Panthers 13
Best Bet: Cardinals -4 (-108)

Detroit Lions vs. Chicago Bears Odds

The hits just keep coming for the Chicago Bears. Chicago’s offense once again failed to deliver in Monday’s loss to Minnesota, and now they’ll return home to face the Detroit Lions in a rematch of their Thanksgiving showdown.

Chicago nearly pulled off the upset in Detroit that day, but it’ll be a much tougher task this time around. The Lions come in fired up with no shortage of motivation after last week’s high-scoring home loss to Buffalo. Detroit will be eager to bounce back and keep pace in the NFC playoff race, making this a daunting challenge for the struggling Bears.

Unfortunately, the injuries continue to pile up for the Lions. Detroit lost star running back David Montgomery for the season after he suffered an MCL injury in last week’s loss. That puts even more responsibility on rookie Jahmyr Gibbs to carry the rushing load, though we could also see the Lions lean more heavily on their passing attack.

Jared Goff is likely up to the challenge after a monster performance last week, throwing for nearly 500 yards and 5 touchdowns in a losing effort. With the Bears’ defense vulnerable against the pass, Goff and the Lions’ high-powered offense should have plenty of opportunities to move the ball through the air.

Chicago was fortunate to keep things close in the last matchup between these two teams, but they won’t be so lucky this time around. Expect the Lions to come out focused, motivated, and ready to take care of business. Detroit should roll on the road and leave no doubt in this one.

Betting Trends:

• Lions are 7-1 ATS in their last 8 games as road favorites.
• Bears are 2-5 ATS in their last 7 games as underdogs.
• The total has gone over in 5 of Detroit’s last 6 games.

Predictions:

• Spread: Lions -6.5 (-110) – Detroit’s offense should control this game from start to finish.
• Moneyline: Lions (-278) – Montgomery and Gibbs should dominate on the ground.
• Total: Over 48 (-110) – Detroit’s offense will put up enough points to cash the over.

Final Score Prediction: Lions 41, Bears 14
Best Bet: Lions -6.5 (-110)

New York Giants vs. Atlanta Falcons Odds

Does this game really need to be played? The Atlanta Falcons are desperately trying to keep pace with the Bucs in the NFC South, but time is running out. Even last week’s trip to Las Vegas wasn’t easy, as Atlanta had to grind out an ugly win over the Raiders.

After the game, head coach Raheem Morris declined to commit to Kirk Cousins as the starter moving forward. That opens the door for Michael Penix Jr. to potentially make his first NFL start this week in what’s about as favorable a matchup as you can ask for against the tanking, no-good, utterly horrific New York Giants.

Michael Penix Jr. spent what felt like eight years playing college football, so he enters the league with far more experience than your typical rookie quarterback. Atlanta has given him no shortage of quality weapons to work with, but I’d be surprised if the Falcons don’t lean on their ground game in this one.

Between Bijan Robinson and Tyler Allgeier, the Falcons have a dynamic rushing attack that should have no trouble against a Giants defense that’s been soft against the run all season. Even if Atlanta rolls with a first-year pro under center, I still like them to control this game and come away with a win.

What is there to say about the Giants? Absolutely nothing. Let’s just keep it moving, friends.

Betting Trends:

• Falcons are 5-2 ATS in their last 7 home games.
• Giants are 1-6 ATS in their last 7 road games.
• The total has gone under in 8 of New York’s last 10 games.

Predictions:

• Spread: Falcons -8.5 (-110) – Atlanta’s defense and run game will dominate.
• Moneyline: Falcons (-440) – The Giants don’t have enough firepower to keep up.
• Total: Under 41 (-110) – This feels like a grind-it-out game where points are at a premium.

Final Score Prediction: Falcons 21, Giants 3
Best Bet: Falcons -8.5 (-110)

Tennessee Titans vs. Indianapolis Colts Odds

Speaking of games that don’t need to be played, the Indianapolis Colts will host the Tennessee Titans this week in a matchup that feels like a formality. Tennessee finally benched a healthy Will Levis last week in favor of Mason Rudolph, and there’s a good chance Rudolph will get the start again on Sunday.

The Colts’ quarterback situation isn’t much better. Anthony Richardson continued his struggles with another dreadful performance in Indy’s Week 15 loss to Denver. This is shaping up to be an ugly, low-scoring game.

Richardson had another rough outing in Denver, completing just 17 of 38 passes with two interceptions and no touchdown throws. He did manage to score on the ground, but at this point, that’s about the only thing he does well in this offense.

Richardson’s struggles have only made life harder for Jonathan Taylor, who still hasn’t found the end zone on the ground since October 27. Without much of a passing threat to keep defenses honest, Taylor has faced stacked boxes week after week, and the results have been underwhelming.

I expect the Colts to win this game simply because the Titans somehow manage to be the worse football team. That said, I want absolutely nothing to do with this one from a betting standpoint. The quarterback play on both sides has been downright brutal, and I think the under is the safest bet here given the offensive ineptitude that’s likely to be on full display.

Betting Trends:

• Colts are 6-1 ATS in their last 7 home games.
• Titans are 2-5 ATS in their last 7 road games.
• The total has gone under in 6 of Tennessee’s last 8 games.

Predictions:

• Spread: Colts -4.5 (-110) – Richardson’s playmaking ability gives Indy the edge.
• Moneyline: Colts (-205) – Indianapolis takes care of business at home.
• Total: Under 42.5 (-110) – Tennessee’s offense won’t score enough to push this over.

Final Score Prediction: Colts 17, Titans 10
Best Bet: Under 42.5 (-110)

Minnesota Vikings vs. Seattle Seahawks Odds

The Minnesota Vikings and Seattle Seahawks are two teams battling for playoff spots in the NFC. Minnesota kept their momentum rolling with yet another win, taking down the Bears at home on Monday Night Football, while Seattle fell at home to the Packers.

To make matters worse for the Seahawks, quarterback Geno Smith went down with a knee injury in that game. While the injury isn’t reported to be serious, it’s unclear if he’ll be ready to suit up this week. If Smith can’t go, we’ll likely see Sam Howell make his first start of the season, adding another wrinkle to Seattle’s already shaky playoff push. Kenneth Walker III is also a question mark after missing the last 2 games with an injury of his own.

I’m still skeptical of the Vikings as true Super Bowl contenders, but they just keep finding ways to win week after week. Minnesota hasn’t been as dominant on the road this season, but there’s real potential for a total collapse on Seattle’s side if Howell is forced into action.

Howell has been a turnover machine throughout his career, and that’s a recipe for disaster against Minnesota’s opportunistic defense. If he gets the start in place of Geno Smith, the Vikings will have plenty of chances to capitalize and put this game away early.

Betting Trends:

• Vikings are 5-1 ATS in their last 6 games overall.
• Seahawks are 4-2 ATS in their last 6 home games.
• The total has gone under in 6 of Minnesota’s last 7 games.

Predictions:

• Spread: Seahawks +3 (-105) – Seattle’s home-field edge keeps this close.
• Moneyline: Seahawks (+130) – The 12th Man proves to be the difference.
• Total: Under 43 (-112) – Both defenses will keep the scoring in check.

Final Score Prediction: Vikings 21, Seahawks 20
Best Bet: Seahawks +3 (-105)

New England Patriots vs. Buffalo Bills Odds

Patriots–Bills has a two-touchdown spread, and honestly, you could argue it should be even bigger. Sure, there’s a chance for a letdown on Buffalo’s side after back-to-back high-stakes games against the Rams and Lions, but let’s be serious here—there’s no way they return home and lose to the freaking Patriots.

Get real, folks. Buffalo wins, Buffalo covers, and they do it in dominant fashion. The whole enchilada.

Betting Trends:

• Bills are 6-2 ATS in their last 8 games as double-digit favorites.
• Patriots are 1-5 ATS in their last 6 games as road underdogs.
• The total has gone under in 5 of Buffalo’s last 7 games.

Predictions:

• Spread: Bills -14 (-112) – Buffalo’s offense is too much for a struggling Patriots team.
• Moneyline: Bills (-950) – There’s no value here, but Buffalo rolls at home.
• Total: Under 46.5 (-110) – The Patriots’ offense likely won’t score enough to push this over.

Final Score Prediction: Bills 41, Patriots 10
Best Bet: Bills -14 (-112)

San Francisco 49ers vs. Miami Dolphins Odds

The San Francisco 49ers and Miami Dolphins are both on the fringe of the playoff picture in their respective conferences, but both teams are limping to the finish line. San Francisco’s offense has completely fallen off a cliff thanks to a rash of injuries, leaving them struggling to move the ball consistently.

Miami, meanwhile, couldn’t get out of their own way last week, as turnovers doomed them in a frustrating loss to Houston. Both squads are desperate to get back on track, but with so many issues on both sides, this one could turn into a battle of who makes fewer mistakes.

The 49ers are yet another West Coast team traveling east this week, and that always comes with its challenges. That said, Miami’s defense—while a relative bright spot—has struggled to generate consistent pressure on opposing quarterbacks.

If the weather holds, Brock Purdy should have enough time in the pocket to operate effectively. Given that, I think the 49ers will find a way to put some points on the board and keep themselves competitive in this one. I get why the Dolphins are favored here, but this team has a loser mentality when it comes to handling adversity. The 49ers, for all their struggles, are still a tough, well-coached team. I’ll take San Francisco to pull off the upset, win outright, and cover on the road.

Betting Trends:

• Dolphins are 6-2 ATS in their last 8 home games.
• 49ers are 5-3 ATS in their last 8 games as road underdogs.
• The total has gone over in 4 of Miami’s last 5 games.

Predictions:

• Spread: 49ers +1.5 (-112) – Miami just hasn’t looked right all year. Not that the Niners have, but still.
• Moneyline: 49ers (+102) – Grab the value with SF to win it outright on the road.
• Total: Over 46 (-110) – These offenses have been less than the sum of their parts all season.

Final Score Prediction: 49ers 24, Dolphins 17
Best Bet: 49ers ML (+102)

Jacksonville Jaguars vs. Las Vegas Raiders Odds

Jaguars–Raiders? Jesus H. Christ. This one’s a masterpiece of mediocrity. The Raiders are gunning hard for that No. 1 pick, and while the Jaguars wouldn’t mind having it too, you just know Vegas wants it more. Expect a whole lot of bad football and even worse decision-making—tank season at its finest.

Please, for the love of all that is good, don’t watch this game. I wouldn’t recommend betting on it either—your time, money, and sanity are worth more than that. Honestly, the world might be better off if we all just pretend this game isn’t happening.

That said… Jaguars win on the road.

Betting Trends:

• Jaguars are 4-1 ATS in their last 5 games as road favorites.
• Raiders are 3-6 ATS in their last 9 home games.
• The total has gone under in 5 of Jacksonville’s last 6 games.

Predictions:

• Spread: Jaguars -1 (-110) – I don’t know, man.
• Moneyline: Jaguars (-115) – The Raiders haven’t won in a while, and they don’t want to win again for a while, either.
• Total: Under 39 (-108) – This one has low-scoring slugfest written all over it.

Final Score Prediction: Jaguars 3, Raiders 0
Best Bet: Jaguars ML (-115)

Tampa Bay Buccaneers vs. Dallas Cowboys Odds

Tampa Bay Buccaneers vs. Dallas Cowboys is yet another mismatch, but here we are, stuck watching it on Sunday Night Football. Has anyone heard of flex scheduling? Seriously, what are we doing here?

Tampa Bay comes in riding high after dismantling the Chargers 40-17 in LA last week, while the Cowboys managed to pull off an upset win over the Panthers. Neither outcome changes the fact that this matchup feels lopsided, and we’re all just along for the ride.

The Bucs are shaping up to be a team that could raise some eyebrows once they get into the playoffs, and I don’t think they’ll stumble here despite a road matchup against the Cowboys. Dallas’ defense has shown some signs of life in recent weeks, but opposing defenses have struggled to slow down Baker Mayfield and this Tampa Bay offense all year—injuries and all.

Mayfield has this group humming, and with how inconsistent the Cowboys have been, I like Tampa Bay to handle business on the road.

Betting Trends:

• Buccaneers are 6-1 ATS in their last 7 games as road favorites.
• Cowboys are 2-4 ATS in their last 6 games overall.
• The total has gone over in 5 of Tampa Bay’s last 7 games.

Predictions:

• Spread: Buccaneers -4 (-110) – Tampa Bay’s offense will be too much for Dallas to handle.
• Moneyline: Buccaneers (-205) – Mayfield and the Bucs stay on track for the playoffs.
• Total: Over 49.5 (-110) – Both offenses should light up the scoreboard.

Final Score Prediction: Buccaneers 31, Cowboys 14
Best Bet: Buccaneers -4 (-110)

New Orleans Saints vs. Green Bay Packers Odds

Speaking of mediocrity, we’re all being subjected to the New Orleans Saints on Monday Night Football as they head to Lambeau to face the mighty Green Bay Packers. Green Bay, on the other hand, looks like the real deal and could be a sneaky dark horse Super Bowl contender out of the NFC.

As for the Saints? Well, they nearly won last week, so I guess they’ve got that going for them. Small victories, I suppose.

The Jake Haener experiment lasted all of one half before he was promptly benched for Spencer Rattler. It’s been that kind of year for the Saints, a team that’s been absolutely crushed by injuries. To make matters worse, Alvin Kamara went down with a groin injury last week, and his status for this game is up in the air.

If Kamara can’t go, we’ll likely see a heavy dose of Kendre Miller in the backfield. That’s fine in theory, but let’s be real—this New Orleans offense is going to have a lot of trouble putting points on the scoreboard at Lambeau.

Joe Buck and Troy Aikman are going to have their work cut out for them trying to fill airtime during this snoozer. The Packers should win this one easily, and it’s hard to see the Saints putting up much of a fight. Expect a one-sided affair with Green Bay cruising to a comfortable victory while the broadcast booth tries to keep things interesting.

Betting Trends:

• Packers are 5-2 ATS in their last 7 games as double-digit favorites.
• Saints are 2-5 ATS in their last 7 road games.
• The total has gone under in 6 of Green Bay’s last 8 games.

Predictions:

• Spread: Packers -13.5 (-110) – Green Bay dominates from start to finish.
• Moneyline: Packers (-800) – A straightforward win at home.
• Total: Under 42 (-112) – The Saints won’t score enough to hit the over.

Final Score Prediction: Packers 35, Saints 10
Best Bet: Packers -13.5 (-110)

NFL Week 16 Best Bets

After analyzing the Week 16 matchups, here are our top betting picks:

• Los Angeles Rams -3.5 (-108) – The Jets’ offense won’t keep pace with Stafford and Nacua.
• Buffalo Bills – 14 (-112) – I am undeterred by the massive spread in this one.
• Tampa Bay Buccaneers -4 (-110) – Mayfield and Tampa Bay’s offense will prove too much for Dallas.

Each of these bets offers strong value on its own, but for those feeling bold, parlaying all three creates a shot at a bigger payout. A $100 parlay on these three picks would return approximately $645 if they all hit.

The Bills’ blowout potential, combined with favorable matchups for the Rams and Bucs, makes this trio my favorite NFL parlay to approach the Week 16 slate. Good luck!