2025 Womens’ Sweet 16 Basketball Odds and Predictions

The road to the 2025 NCAA Women’s Championship still goes through UCLA. The Bruins are still alive in the women’s March Madness tournament, and the tourney’s #1 overall seed remains a threat to cut down the nets when it’s all said and done.

They will take on five-seed Ole Miss when the Sweet 16 gets going, and as is the case with most #1 seeds in the women’s tourney, they’re fully expected to advance.

Betting on the Sweet 16 can be fun, so long as you don’t take too many risks. The women’s tourney is not the place for outlandish bets or wild upsets, after all. In fact, there were just four round one upsets this year, and none of them were higher than the 10th seed.

While the women’s college basketball tournament is short on Cinderella’s, it’s still high on talent and competition as we inch closer to the Final Four. If you’re looking for College Basketball picks for the women’s side of things, read on as I break down the latest women’s Sweet 16 odds and offer my predictions.

Sweet 16 Schedule

It’s important to know the NCAA Sweet 16 schedule if you plan on placing bets before or during the games.  Here is each Sweet 16 matchup and the date and time for the game.

• Ole Miss (5) vs. UCLA (1) – Friday, March 28th
• Maryland (4) vs. South Carolina – Friday, March 28th
• UNC (3) vs. Duke (2) – Friday, March 28th
• LSU (3) vs. NC State (2) – Friday, March 28th
• Notre Dame (3) vs. TCU (2) – Saturday, March 29th
• Tennessee (5) vs. Texas (1) – Saturday, March 29th
• Kansas State (5) vs. USC – Saturday, March 29th
• Oklahoma (3) vs. UConn (2) – Saturday, March 29th

Sweet 16 Locations

The women’s Sweet 16 locations will be divided between two spots for the next segment of the 2025 tourney:

• Legacy Arena in Birmingham, Alabama
• Spokane Arena in Spokane, Washington

Sweet 16 Bracket

The initial Sweet 16 odds shock nobody, as the top seeds are understandably favored to move on. That isn’t to say they won’t get tested, nor that an upset couldn’t be brewing in one of these battles.

However, top seeds don’t often fall this early in the women’s tournament. Just look at last year; two one-seeds battled for the title, while the other two one-seeds didn’t lose until the Elite 8.

Could we see a high seed knocked off a bit earlier this time around? Only time will tell. You can roll with my picks in the table above, read on for more reasoning as to why I am predicting the games to go this way, or utilize some of the best handicappers available online to perfect your March Madness bets.

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Sweet 16 Predictions

Check out our NCAAW predictions for each Sweet 16 matchup:

Spokane 1 Sweet 16

The Spokane 1 Region has gone as many assumed it would, with top seed UCLA coasting to the Sweet 16 and only four-seed Baylor failing to advance as expected.

UCLA Bruins (-340) vs. Ole Miss Rebels (+270)

• Spread: (+7.5) -110, (-7.5) -110
• Total: O 134.5 (-110), U 134.5 (-110)

The one-seed Bruins are fully expected to march on to the Elite 8 on Friday. They will have an easier than expected challenge in front of them, as the 22-10 Rebels weren’t the team they thought they’d be facing.

To this point, it’s been smooth sailing for UCLA (32-2), with blowout wins over Southern and Richmond in their first two games. Ole Miss won easily against 12-seed Ball State in round one, and then staged a mild upset over four-seed Baylor in round two, 69-63.

Ole Miss deserves credit for making it this far, but they simply don’t have the firepower to match wits with the Bruins. USC is the only team to take down the Bruins this year (twice), and they simply rebound the ball too well and are too efficient offensively.

Bet: UCLA Bruins (-340)

NC State Wolfpack (+120) vs. LSU Tigers (-140) 

• Spread: (-2.5) -110, (+2.5) -110
• Total: O 153.5 (-110), U 153.5 (-110)

The LSU Tigers will continue their march to what they hope will be another title. They’ve enjoyed a strong 30-5 season to this point, and so far they have been lights out, averaging 102 points per game during March Madness.

LSU is equipped offensively to get the job done against NC State, and they have their eyes set on a much bigger prize. The Wolfpack are no joke, of course, as their defense has been nasty through two tourney games, limiting their opponents to 55 points or fewer thus far.

Legendary head coach Kim Mulkey is not one to bet against, however. She will have full control over this game, as LSU has made it to the Elite 8 in each of her last two seasons calling the shots.

With superstar Flau’Jae Johnson (18.8 points per game) leading the way, I’d bet on the Tigers at least advancing to the next round.

Bet: LSU Tigers (-140)

Birmingham 2 Sweet 16

The Birmingham 2 Region saw defending champion South Carolina put up 108 points in round one, and then have difficulty with Indiana in round two. It’s otherwise gone as expected, with all four of the top seeds reaching the Sweet 16.

South Carolina Gamecocks (-4000) vs. Maryland Terrapins (+1300)

• Spread: (+17.5) -110, (-17.5) -110
• Total: O 150.5 (-110), U 150.5 (-110)

The defending champion Gamecocks look ready to defend their title. Dawn Staley’s crew won 32+ games for the fourth year in a row, and they look poised to give it a go and their third title in four seasons.

Betting against South Carolina has been a losing endeavor for years now. Titles aside, they’ve at least reached the Final Four in each of the last four seasons, and probably would have made it five in a row if the 2019 March Madness hadn’t been cancelled.

South Carolina has looked sharp so far in the tourney, as they put up 108 points in round one and then suffocated Indiana in round two. Their offense saw a drop in their second game, but they are such massive favorites that betting against them feels like a huge mistake.

Maryland (25-7) looks dangerous offensively, but they needed an insane OT finish just to get here. I think their journey ends with a big loss to the Gamecocks.

Bet: South Carolina Gamecocks (-4000)

Duke Blue Devils (-240)) vs. UNC Tar Heels (+200) 

• Spread: (+6.5) EVEN, (-6.5) -120
• Total: O 124.5 (-115), U 124.5 (-105)

Two-seeded Duke has been on a tear. Their defense has been absurdly good (allowed 25 points in round one!), and they’ve won six straight to get here. One of those wins was over this very North Carolina squad, and they did so in convincing fashion.

All year, the Blue Devils have flashed elite defensive chops, with just six teams topping 70 points against them all season long. Their lack of elite offense, however, could be a problem for them in a matchup where their opponent knows them all too well.

North Carolina lost the most recent showdown, but the Tar Heels did beat Duke in a tense, low-scoring overtime battle back in January. UNC has displayed an equally gritty defense, so this one feels like a toss-up. All things considered, I am digging the value with North Carolina in a third meeting with their ACC rivals.

Bet: UNC Tar Heels (+200)

Birmingham 3 Sweet 16

Tennessee is responsible for the biggest upset in this region, as the Vols destroyed Ohio State in round two (82-67) to set up a huge showdown with Texas. Texas remains the favorite to escape this region, however, while Notre Dame and TCU duke it out for a right to reach the Elite 8.

Texas Longhorns (-340) vs. Tennessee Volunteers (+270)

• Spread: N/A
• Total: O 155.5 (-105), U 155.5 (-115)

Texas comes into the Sweet 16 as sizable betting favorites, as the Longhorns trounced William & Mary in round one and handled Illinois in round two. They may get a stiffer test against the Volunteers, who have looked pretty good at both ends of the floor through two rounds.

Tennessee held both of their first two opponents under 68 points, and they’re averaging 91.5 points per game so far. They will certainly need to keep that rolling against Texas, who has a suffocating defense and a bruising interior presence in Madison Booker.

It’s possible the Vols do enough to make this a game early, but the full expectation is for Texas to win, and they’ll probably win big.

Bet: Texas Longhorns (-340)

TCU Horned Frogs (+180) vs. Notre Dame Fighting Irish (-215)

• Spread: (-5.5) -110, (+5.5) -110
• Total: O 144.5 (-105), U 144.5 (-115)

I’m calling the upset. It’s actually not technically an upset, seeing as the TCU Horned Frogs are the higher seed and own the better record (33-3), but Notre Dame is the more storied school and they enter the Sweet 16 as -215 betting favorites.

Notre Dame (28-5) is nothing to scoff at, as The Fighting Irish have dominated so far, dropping 106 points on SF Austin in round one, and beating Michigan by 21 in round two. Elite defense has been their calling card, and they’ll hope to slow down a TCU team that has been nearly as dominant through two rounds.

TCU is on fire right now. Winning the Big 12 is impressive enough, but they’re riding a sick 10-game winning streak, with much of their success thanks to an elite defense. Former LSU star Hailey Van Lith is a huge reason for their season, while their spread out scoring mirrors that stingy defense to give them a balanced attack.

Notre Dame is the favorite and very much a threat to advance, but I love the value we get with a battle tested TCU squad that feels like the superior team. You won’t find me chasing women’s March Madness upsets often, but value like this is too good to ignore.

Bet: TCU Horned Frogs (+180)

Spokane 4 Sweet 16

The 2025 March Madness tourney was thrown on its side thanks to a devastating injury to USC phenom, JuJu Watkins. USC still has a shot at a title, but their bad luck opens the door for UConn to emerge out of this region.

USC Trojans (N/A) vs. Kansas State Wildcats (N/A)

• Spread: N/A
• Total: N/A

The top March Madness betting sites have not released women’s Sweet 16 odds for this game, as USC just played last night and lost superstar JuJu Watkins to a torn ACL.

The Trojans were still able to easily move past Mississippi State, which is a good example for why giving up on them entirely is probably a big mistake. The injury isn’t just deflating, though, as Watkins was the key to this team’s offense (23.9 points per game).

USC almost certainly isn’t running the table without arguably the best player in women’s college basketball, but I do think they can still beat Kansas State. The Wildcats are a solid team with a more than capable offense, but they won’t be able to stifle USC even without their top scorer.

Obviously there is the narrative that losing Watkins could shellshock USC. If they play with heavy hearts, an upset isn’t impossible. I’m just betting against that – for now.

Bet: USC Trojans (N/A)

UConn Huskies (-1200) vs. Oklahoma Sooners (+700)

• Spread: (+14.5) -110, (-14.5) -110
• Total: O 153.5 (-115), U 153.5 (-105)

Geno Auriemma is undeniably one of – if not the – greatest women’s CBB coaches of all-time. As great of a career as he’s had, things haven’t gone as planned for some time. UConn has played in one national championship game in the last nine years, and they haven’t secured a title since 2025-16.

It’s possible that changes this year, or at least UConn’s odds received a boost. The JuJu Watkins injury is massive for them, while they are huge betting favorites as they prepare to take on an inferior Sooners squad.

UConn is a stout 33-3 on the year, and they haven’t lost since falling to Notre Dame in December. They’ve looked fantastic so far during March Madness, playing blistering defense and riding stellar play from Paige Bueckers (34 points in round one).

The Huskies are simply going to be too much for Oklahoma to handle. Oklahoma had a good season, but when put up against the truly elite teams, they more than often folded. I expect that to happen again here.

Bet: UConn Huskies (-1200)