Week 17 Monday Night Football Odds: Lions vs. 49ers

The Monday Night Football odds are live for Week 17, which gives fans a decent matchup between the Detroit Lions and the San Francisco 49ers.

This was supposed to be an awesome MNF clash, but San Francisco’s struggles made it less of a must-see game. That said, there are instantly some solid bets worth targeting in this game, and I’ll be highlighting my top MNF picks.

Want more primetime betting action? Be sure to check out the Week 17 Sunday Night Football betting preview before MNF rolls around. With that, let’s dive into the latest odds for this Lions vs. 49ers showdown in the Bay Area.

What Channel is Monday Night Football On?

• Monday Night Football Channel: ESPN and ABC
• Monday Night Football Time: 8:15 pm ET
• Monday Night Football Announcers: Joe Buck and Troy Aikman

You can watch Monday Night Football on ESPN like always, while the legendary Joe Buck and Troy Aikman continue to call the biggest NFL primetime game of the week.

The action between the Detroit Lions and San Francisco 49ers fires off at 8:15 pm EST and can be viewed on ESPN.

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Monday Night Football Betting

This game was supposed to be an intense clash with playoff implications. Instead, the Niners are out of the playoff race and the Lions hope this isn’t a trap game leading into a massive week 18 battle.

If the opening lines are any indication (Lions are -195 favorites), Detroit shouldn’t have a major issue getting past San Francisco. That said, it’s not a crazy spread (-3.5), so the bookmakers are not projecting a blowout or even an easy victory.

San Francisco could put up a fight here, but I wouldn’t expect the odds to shift much, if at all.

I’ll break down the latest Monday Night Football odds and point you to my preferred plays, but I do highly suggest using our sports betting handicapping service. Check out our free trial.

Monday Night Football Odds

Here are the latest MNF NFL odds for this Detroit Lions vs. San Francisco 49ers tilt.

The Detroit Lions will be road favorites for this one, and there isn’t much logic in betting against them. They have a huge week 18 title awaiting them, where they’ll play the Minnesota Vikings for the NFC North crown.

That said, the 49ers are still well-coached, they’re at home, and they do still have some solid talent. I wouldn’t be shocked to see them give the Lions a good fight, and the MNF odds do indicate as much.

If you want to bet right now, I would still hammer the Lions to win, I think the Lions will also cover, and I wouldn’t be shocked if the game hit the Over, either.

You can visit the top online NFL betting sites to take advantage of any of these wagers, or read on for some interesting Lions vs. 49ers betting trends, some MNF props, and my preferred bets.

Monday Night Football Betting Trends

Before you bet on MNF in Week 17, consider some Lions vs. 49ers betting trends:

Lions vs. 49ers Betting Trends

• 49ers are 40-28-1 in all-time series
• 49ers are 4-1 in last 5 meetings
• Over is 3-2 in last 5 meetings

Detroit Lions Betting Trends

• Lions are 10-5 ATS in 2024
• Lions are 10-2 ATS as road favorites since 2023
• Over is 8-7 in 2024

San Francisco 49ers Betting Trends

• 49ers are 5-10 ATS in 2024
• 49ers are 0-2 ATS as underdog since 2023
• Over is 8-7 in 2024

Monday Night Football Predictions

RReady for some Lions vs. 49ers betting picks? First, let’s analyze both team’s chances of getting a win this week:

Detroit Lions Outlook

The Detroit Lions are trying to put the finishing touches on a truly remarkable 2024 campaign. They could easily be undefeated right now, but dropped two tightly contested games at home on the season.

That makes Detroit perfect on the road, and they’ll be the clear betting favorites as they travel to San Francisco to battle the hapless 49ers. This would normally be a game of high magnitude, but the Niners are dealing with a slew of key injuries and simply have very little to play for.

Detroit has everything to lose here, as a big week 18 battle for first place in the NFC North awaits them. They also still have their sights set on claiming the #1 seed in the NFC, but they need to win out to ensure that happens.

Logic suggests they can, as the Lions don’t have many glaring weaknesses. They enter Monday Night Football with the top scoring offense in all of football (32.9 points per game), and a top 10 scoring defense (19.9).

The Lions seem to drop 30+ points almost every week, as star talent like Jahmyr Gibbs, Amon-Ra St. Brown, Sam LaPorta, and Jameson Williams all take turns going off, depending on the matchup.

Detroit’s ground game should be the focus here, as the 49ers do have a capable pass rush (13th in sack rate) and a stingy secondary (3rd against the pass). Gibbs could have a field day here, though, as the 49ers have struggled stopping the run (15th) and De’Von Achane went nuts last week in a loss to the Miami Dolphins.

The weakness for Detroit is their defense. They have taken a step back in recent weeks, and while they tend to stop the run as well as anyone (4th), their secondary gives up big plays and they can get into shootouts.

San Francisco 49ers Outlook

The 49ers don’t have anything to play for but pride in this one. That could still be enough, as they are at home and this is a rematch of last year’s NFC title game.

On paper, San Francisco projects well through the air. This is a solid matchup for the likes of Brock Purdy, Deebo Samuel, and George Kittle. Samuel finally got going again last week, so it wouldn’t be shocking at all for him, Kittle, or even Jauan Jennings to pop off in this matchup.

Things could be more difficult on the ground. Patrick Taylor struggled as the fill-in starter at running back last week, so the Niners will probably hope injured rookie Isaac Guerendo can return from foot and hamstring ailments.

It may not matter, though. While the Niners have proven over the years they can excel on the ground given their dynamic rushing scheme and offensive line, the Lions have been stout in this department all year.

If the 49ers are going to win, it’s almost a guarantee they’ll need a huge game out of Purdy and the passing game, and it’ll likely be in a high-scoring shootout.

Defensively, the 49ers aren’t what they once were. The Lions are a terrible matchup for them at this point, so their only hope is to find a way to put up more points.

Who Will Win: Lions or 49ers?

The Lions are an absolute smash at their current moneyline. Their -195 price tag does not feel high at all given how good they are, how much the Niners have struggled, and how important winning this game is to them.

It’s always possible this game gets out of control and the 49ers play spoiler. If you believe that, though, I’d rather bet on the 49ers to beat the spread, or simply hammer the Over when it comes to the game total.

That isn’t something I am personally worried about, though. I see Detroit winning, so I am very high on the ML, Detroit to cover, and the Over.

Bet: Detroit Lions (-195)

Monday Night Football Prop Bets

There is more to betting on MNF than the game itself. Take advantage of some fun MNF prop bets for week 17:

Race to 20 Points

• 49ers (+129)
• Lions (-167)

This isn’t a bad MNF prop bet if you think the Lions win, but aren’t super excited to bet on the total and want a better ML for Detroit. This bet plays into both, but it’s always possible San Francisco doesn’t live up to their end of the bargain.

Bet: Lions (-167)

49ers Total Field Goals Made

• Over 1.5 (-122)
• Under 1.5 (-114)

The 49ers should put up enough points to contribute to the Over, but I don’t know how I feel about them coming in and scoring three touchdowns necessarily.

I don’t mind betting on Jake Moody to try and make at least two field goals, though. He’s attempted at least two field goals in three of his last four games, and the Lions are leaky enough defensively to allow San Fran to get into scoring position numerous times.

Bet: Over 1.5 (-122)

Best Bets for Monday Night Football

The Detroit Lions have serious Super Bowl aspirations. Part of their plan is winning their division and locking up the top seed in the NFC, and beating the 49ers plays into that.

I don’t see the Lions faltering here – and perhaps not even the rest of the year – so some of my favorite week 17 MNF bets have to do with that.

There are a lot of Monday Night Football wagers that look appealing, but I’ve listed my favorites:

• Detroit Lions ML (-195)
• Detroit Lions (-3.5) -105
• Over 51 (-105)

Detroit is going to win this game and I wouldn’t be that shocked if they did it in convincing fashion. They’ve allowed some teams to play them close and their defense is far from perfect, though, so I also really like this game to hit the Over.

You can roll with any of the Monday Night Football prop bets I’ve detailed, but there really aren’t a lot of appealing wagers out there yet. Once they drop, I’d be targeting Jahmyr Gibbs Over bets and I’d also have a look at 49ers passing game weapons Overs.

For now, I’ll stick with the straight bets listed above, and you can also try my MNF props.

Don’t feel amazing about week 17 MNF wagers? Luckily there’s a ton out there to get excited about. Stop by our week 17 NFL player props for some more betting options.

Want more primetime betting opportunities? Give our NFL Christmas Day betting preview a look, too. Good luck this week!

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