San Francisco 49ers Betting Guide for 2024

Betting on the San Francisco 49ers in the 2024 season offers plenty of exciting opportunities—but finding the right bets and maximizing value can be challenging. Whether you’re betting on point spreads, player props, or game totals, having a clear understanding of how the 49ers perform on the field is crucial. 

This guide is designed to help bettors—both experienced and new—make smarter, more informed decisions when wagering on the 49ers. From player analysis to team trends, we’ll walk you through the key factors that impact betting outcomes. And with our expert handicapping services, you can take your betting strategy to the next level, ensuring you don’t miss any profitable opportunities this season.

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Latest Picks and Betting Odds for the San Francisco 49ers

Check out our latest picks for the upcoming 49ers’ games:

Odds to Win
SUPERBOWL

+450

Odds to Win
NFC Conference

+225

Odds to Win
Division

-1000

Seasons Win

11+120 Over
11- 140 Under

San Francisco 49ers 2024 Team Stats

Below is a breakdown of the San Francisco 49ers stats for the 2024 season:

https://sportstats.nypost.com/football/nfl/teamstatistics/5

San Francisco 49ers Injury Updates

Check out the latest injury updates for the San Francisco 49ers here:

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Get the latest San Francisco 49ers injury updates here at ScoresandStats.com. With this report you’ll gain valuable betting insights for this season. For more betting advice you can also sign up and view even more information.

Brief History of the San Francisco 49ers

The San Francisco 49ers were founded in 1946 as a member of the All-America Football Conference (AAFC) before joining the NFL in 1950. The early years were marked by modest success, but it wasn’t until the late 1970s, when head coach Bill Walsh took the helm, that the 49ers began to rise to prominence. Walsh introduced the innovative “West Coast offense,” a passing-focused system that revolutionized the game. In 1979, the team drafted Joe Montana, one of the greatest quarterbacks in NFL history, setting the stage for a dynasty that would dominate the NFL throughout the 1980s.

The 49ers won their first Super Bowl in 1982, defeating the Cincinnati Bengals in Super Bowl XVI. This victory was followed by more championships in 1984, 1988, and 1989, solidifying the team’s place as a powerhouse. Key players during this era included Montana, wide receiver Jerry Rice, and safety Ronnie Lott. After Montana’s departure, Steve Young took over as quarterback, leading the team to its fifth Super Bowl victory in 1994. These years cemented the 49ers’ legacy as one of the most successful franchises in NFL history.

The late 1990s and early 2000s saw a downturn for the 49ers as they went through several rebuilding phases, struggling to find success. The franchise was revitalized in the 2010s under head coach Jim Harbaugh, who led the team to the Super Bowl in 2012, though they narrowly lost to the Baltimore Ravens. After a period of transition, Kyle Shanahan became head coach in 2017, and the 49ers again became contenders, making another Super Bowl appearance in 2019. With a talented roster featuring stars like Brock Purdy, Christian McCaffrey, and Nick Bosa, the 49ers enter the 2024 season with high hopes for continued success.

Timeline of the San Francisco 49ers Franchise

  • 1946: San Francisco 49ers founded as a member of the All-America Football Conference (AAFC).
  • 1950: 49ers join the NFL after the AAFC merges with the league.
  • 1979: Bill Walsh is hired as head coach; begins the construction of the 49ers’ dynasty.
  • 1979: Joe Montana drafted in the third round, who would become one of the greatest quarterbacks in NFL history.
  • 1981: The 49ers win their first NFC Championship; famous for “The Catch” by Dwight Clark in the NFC Championship Game against the Dallas Cowboys.
  • 1982: The 49ers win their first Super Bowl (Super Bowl XVI), defeating the Cincinnati Bengals 26-21.
  • 1984: San Francisco wins their second Super Bowl (Super Bowl XIX), defeating the Miami Dolphins 38-16, with Joe Montana as MVP.
  • 1985: Jerry Rice, one of the greatest wide receivers in NFL history, is drafted.
  • 1988: The 49ers win their third Super Bowl (Super Bowl XXIII), defeating the Cincinnati Bengals 20-16 with a last-minute drive led by Joe Montana.
  • 1989: San Francisco wins their fourth Super Bowl (Super Bowl XXIV), defeating the Denver Broncos 55-10 in a dominant performance. Joe Montana is named MVP.
  • 1994: Steve Young leads the 49ers to their fifth Super Bowl victory (Super Bowl XXIX), defeating the San Diego Chargers 49-26. Young throws a record six touchdown passes and is named MVP.
  • 1999: Steve Young retires, marking the end of an era for the 49ers’ quarterback legacy.
  • 2000s: The 49ers enter a rebuilding phase, missing the playoffs frequently during the early and mid-2000s.
  • 2011: Jim Harbaugh is hired as head coach; leads the 49ers to the NFC Championship game, revitalizing the team.
  • 2012: Colin Kaepernick takes over as starting quarterback, leading the 49ers to Super Bowl XLVII, where they lose to the Baltimore Ravens 34-31.
  • 2014: Harbaugh leaves the 49ers after a successful stint, leading to several transitional years for the franchise.
  • 2017: Kyle Shanahan is hired as head coach, and the 49ers trade for quarterback Jimmy Garoppolo.
  • 2019: 49ers reach Super Bowl LIV but lose to the Kansas City Chiefs 31-20.
  • 2021: The 49ers draft quarterback Trey Lance with the third overall pick, signaling a new era.
  • 2022: Brock Purdy, a seventh-round draft pick, emerges as a breakout star after injuries to starting quarterbacks.
  • 2023: The 49ers reach the NFC Championship Game but fall short of the Super Bowl.
  • 2024: Entering the 2024 season with a highly talented roster, including key players such as Brock Purdy, Christian McCaffrey, Deebo Samuel, and Nick Bosa, the 49ers are considered strong contenders for a Super Bowl run.

The 2024 NFL season presents several exciting opportunities for bettors looking to capitalize on the San Francisco 49ers’ strengths. Based on player projections, team dynamics, and expected performance, here are some bet types that could prove profitable when betting on the 49ers this year.

49ers to Cover the Spread in Most Games: With the 49ers returning many of their key players from the 2023 season, they are once again expected to be one of the league’s top teams in 2024. Their balanced offense, led by quarterback Brock Purdy and a top-tier defense anchored by Nick Bosa, makes them strong contenders to cover the spread in many matchups.

Betting the Over on Christian McCaffrey’s Total Yards: Christian McCaffrey is projected to remain the centerpiece of the 49ers’ offensive strategy in 2024, both as a running back and receiver. His versatility makes him a prime candidate for total yardage bets, particularly those that combine his rushing and receiving stats.

Brock Purdy Passing Touchdowns Prop Bets: Brock Purdy, now the unquestioned starter going into the 2024 season, has shown the ability to efficiently manage the offense and distribute the ball to a wide array of playmakers like Deebo Samuel, George Kittle, and Brandon Aiyuk. Given the quality of his weapons, Purdy’s touchdown total props offer value.

Nick Bosa Sack Prop Bets: Nick Bosa, the reigning Defensive Player of the Year, will remain one of the most disruptive forces in the league in 2024. His ability to consistently pressure quarterbacks makes sack prop bets one of the most attractive betting options when wagering on 49ers games.

49ers to Win by Double-Digit Margins: In 2023, the 49ers proved they could not only win games but dominate opponents with significant margins. Given the strength of their 2024 roster, betting on the 49ers to win by double-digit margins in favorable matchups could continue to be a profitable strategy.

George Kittle Anytime Touchdown Bets: George Kittle is not only a key contributor in the passing game but also a red-zone target for the 49ers. His ability to create mismatches with linebackers and safeties makes him a solid option for anytime touchdown bets.

The San Francisco 49ers had a strong 2023 season, and several betting trends emerged that proved to be consistently profitable for those who closely followed the team’s performance. Below are some key trends that bettors should be aware of as they consider betting on the 49ers in the 2024 season, based on the team’s 2023 performance:

Strong Performance Against the Spread (ATS): The 49ers were one of the most reliable teams against the spread (ATS) in 2023, covering the spread in many of their games. Thanks to a well-rounded team, elite defense, and efficient offense, the 49ers often exceeded expectations set by oddsmakers, especially in games where they were favored.

Dominance in Home Games: The 49ers were dominant at home throughout the 2023 season, performing well both straight up (SU) and against the spread. Levi’s Stadium proved to be a fortress, as the team’s defense typically stifled opposing offenses, while the offense thrived.

Unders in Low-Scoring Games: In 2023, the 49ers’ defense was one of the best in the NFL, consistently holding opposing teams to low point totals. This led to many games hitting the under on point totals, especially when facing teams with struggling offenses.

Player Props for Christian McCaffrey: Christian McCaffrey, after being traded to the 49ers during the 2022 season, proved to be a key asset throughout 2023. His consistency in both rushing and receiving made him a frequent target for prop bets.

Betting on 49ers’ Big Wins (Double-Digit Margins): The 49ers were not just winning games in 2023; they were doing so in dominant fashion, often defeating opponents by double-digit margins. With a balanced offense and a top-tier defense, San Francisco frequently blew out weaker teams, particularly in non-divisional matchups.

First-Half Bets: In 2023, the 49ers were often quick to establish control of games, particularly in the first half. Their ability to score early and rely on their defense to limit the opposition allowed them to enter halftime with significant leads.

San Francisco 49ers Schedule for 2024

Below is the schedule for the San Francisco 49ers this season:

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San Francisco 49ers Depth Chart

Below is a look at the San Francisco 49ers current depth chart:

https://www.espn.com/nfl/team/depth/_/name/sf/san-francisco-49ers

Key Players for Betting on the 49ers

When betting on NFL games, sportsbooks set their odds based on a variety of factors, including team performance, individual player statistics, injuries, and recent trends. For the San Francisco 49ers in the 2024 season, certain players are critical to the team’s success and, as a result, heavily influence the betting lines. Below, we break down the key players to consider when placing bets on the 49ers, and why they matter from a betting perspective.

Brock Purdy – Quarterback

Brock Purdy, the 49ers’ starting quarterback, enters the 2024 season with a lot of expectations following his breakout performance in 2023. Sportsbooks will closely monitor his performance, especially given how pivotal the quarterback position is in setting game lines and player prop bets. Purdy is known for his efficiency, low turnover rate, and ability to manage the game under pressure.

  • Betting Impact: If Purdy continues to show consistent play, you can expect tighter point spreads and higher totals in games where the 49ers are favorites. His ability to avoid mistakes often keeps the game close, so when betting on the 49ers, consider his impact on spread and total points bets, especially when facing tough defenses.
  • Prop Bets: Purdy’s passing yards, touchdown totals, and interception props will be popular betting options. If you notice favorable matchups against weak secondaries, betting on Purdy’s passing yardage totals could be a solid play.

Christian McCaffrey – Running Back

Christian McCaffrey is arguably the 49ers’ most valuable offensive weapon, capable of making plays both on the ground and through the air. As a dual-threat running back, McCaffrey’s versatility forces sportsbooks to adjust player prop lines for both rushing and receiving yards. His ability to break off big plays can also influence live betting, as a single McCaffrey run can change the momentum of a game.

  • Betting Impact: When McCaffrey is healthy and playing at his peak, expect the 49ers’ total points to trend higher, particularly when playing against weaker run defenses. His presence on the field typically leads to shorter odds on anytime touchdown scorer markets due to his high touchdown potential.
  • Prop Bets: McCaffrey’s rushing and receiving yard totals are often combined, giving bettors a chance to wager on his overall yardage. Additionally, he is a frequent target in red-zone situations, making him a strong choice for anytime touchdown scorer bets.

Brandon Aiyuk – Wide Receiver

Brandon Aiyuk has emerged as a reliable deep threat for the 49ers, and his chemistry with Brock Purdy continues to develop. Aiyuk’s ability to stretch the field makes him a critical player in big-play situations, and his impact can swing both point totals and prop bets.

  • Betting Impact: Aiyuk’s deep-threat potential can increase the chances of the 49ers hitting the over in total points, particularly in games against defenses that struggle against vertical passing attacks. His presence also affects Purdy’s passing yard totals, as one or two big plays can easily boost those numbers.
  • Prop Bets: Look for Aiyuk’s receiving yard totals and long reception props. If the 49ers are playing against a team with a weak secondary, betting on Aiyuk to go over his receiving yards or score a touchdown could be a profitable play.

Deebo Samuel – Wide Receiver

Deebo Samuel is one of the most dynamic and versatile players in the NFL, known for his ability to play as both a wide receiver and a running back. His “wide back” role, where he takes handoffs as well as short passes, makes him difficult to defend and, from a betting perspective, hard to predict. However, his ability to generate yards after the catch and break tackles means he can drastically change the outcome of a game with a single play.

  • Betting Impact: Deebo’s versatility often forces sportsbooks to adjust the game total and player prop lines. His ability to rack up rushing and receiving yards impacts game totals, as he can contribute points in a variety of ways. Watch for his injury status; if he’s fully healthy, the 49ers’ offense becomes far more explosive, increasing the likelihood of overs hitting in total points bets.
  • Prop Bets: Samuel’s combined rushing and receiving yard props are common offerings in betting markets. Also, his ability to score touchdowns in unconventional ways makes him an interesting bet for anytime touchdown scorer props.

George Kittle – Tight End

George Kittle remains one of the most dominant tight ends in the league, known for his blocking, physicality, and game-breaking ability as a receiver. Kittle’s presence on the field is often a matchup nightmare for opposing defenses, especially in the red zone, where he is a prime target for Brock Purdy.

  • Betting Impact: Kittle’s contributions are often reflected in the team’s ability to sustain long drives, which can impact totals and game outcomes. His versatility as a blocker also opens up the run game, which can affect rushing prop lines, especially for McCaffrey. If Kittle is healthy and involved, expect the 49ers to be more balanced, leading to more efficient offensive drives and higher game totals.
  • Prop Bets: Kittle’s receiving yardage props and anytime touchdown markets are popular. He is often a go-to option in third-down situations and red-zone plays, making him a strong candidate for bets involving receiving touchdowns or yardage totals.

Nick Bosa – Defensive End

Although most bettors focus on offensive players, Nick Bosa’s role as the anchor of the 49ers’ defense makes him a critical factor in any bet involving San Francisco. As the reigning Defensive Player of the Year, Bosa is a game-changer when it comes to sacks, tackles for loss, and overall disruption of opposing offenses. His pressure on opposing quarterbacks often results in turnovers or stalled drives, which directly influences point totals and spread bets.

When evaluating betting options, keep in mind Bosa’s ability to control the pace of the game through his defensive dominance. His impact can be felt in games with lower total points or where San Francisco is expected to win comfortably due to a suffocating defense.

Keep Up with the Latest on the 49ers

Keep up on the San Francisco 49ers this season and check out all our latest blog posts:

Will The 49ers Finally Overcome Their Super Bowl Woes?

The San Francisco 49ers enter the 2024 season as one of the NFL’s most formidable teams, offering a wide range of profitable betting opportunities. From betting on them to cover the spread and win by large margins, to focusing on player props like Christian McCaffrey’s total yards and Nick Bosa’s sack totals, there are plenty of angles for bettors to capitalize on.

However, we understand that keeping up with all the stats, trends, and projections can be time-consuming. To help you become a more informed bettor and save valuable research time, consider signing up for our expert handicapping services. Our team of analysts does the heavy lifting, providing you with insider insights and detailed betting recommendations. Whether you’re looking to improve your game or gain a competitive edge, our expert advice will help guide your betting strategy all season long.